Injecting at night vs day

fmalianos · Nov 25, 2015

I know everyone has their own preference on what time of the day but I was thinking...

If a male's body naturally produces testosterone during sleep, wouldn't it make sense to inject at bedtime to mimic the body's own natural state? I inject around lunch time 3times a week subq.

Any comments, thoughts?

Vince · Nov 25, 2015

If you inject T every 3 1/2 days (or more), your levels stay nice and even = less problems

fmalianos · Nov 26, 2015

Yeah but I like to split my doses into 3 times a week. At one point I was doing daily, then went to EOD and now 3x per week. If there's a benefit to going back to daily (night time) I might try that out . Thanks for your input 😊

CoastWatcher · Nov 26, 2015

How much testosterone are you injecting? Are you working to control estradiol, is that why you have made the frequency changes?

Superman · Nov 26, 2015

i inject sunday morning and wednesday evening and I dont notice any difference between night and day

Vince · Nov 26, 2015

fmalianos said:
Yeah but I like to split my doses into 3 times a week. At one point I was doing daily, then went to EOD and now 3x per week. If there's a benefit to going back to daily (night time) I might try that out . Thanks for your input 

no benefit, to daily injecting compared to three days a week

CoastWatcher · Nov 26, 2015

Vince said:
no benefit, to daily injecting compared to three days a week

I've read this many times, but when my E2 ran wild this past summer, I went from twice-weekly dosing to three-day-a-week doing. Estradiol dropped a bit, when I went to daily dosing in an effort to avoid an AI, my E2 slid right down into range. I was surprised, but pleased.

Vince · Nov 26, 2015

CoastWatcher said:
I've read this many times, but when my E2 ran wild this past summer, I went from twice-weekly dosing to three-day-a-week doing. Estradiol dropped a bit, when I went to daily dosing in an effort to avoid an AI, my E2 slid right down into range. I was surprised, but pleased.

That's good to know, did it affect your testosterone panel in any other ways.

CoastWatcher · Nov 26, 2015

Vince said:
That's good to know, did it affect your testosterone panel in any other ways.

Free testosterone remained where it has been since first levels were stabilized. Total testosterone did increase, but not to the point of significance. SHBG was stable.

Lancealot · Nov 26, 2015

fmalianos said:
Yeah but I like to split my doses into 3 times a week. At one point I was doing daily, then went to EOD and now 3x per week. If there's a benefit to going back to daily (night time) I might try that out . Thanks for your input 

How do you feel on 3 times per week? How did you feel on every day inject? What caused you to switch? I guess im lucky in that I have done inject every 3.5 days with no problems and feel great. I think I would have needle fatigue if I had to inject every day or every other.

CoastWatcher · Nov 26, 2015

Lancealot said:
How do you feel on 3 times per week? How did you feel on every day inject? What caused you to switch? I guess im lucky in that I have done inject every 3.5 days with no problems and feel great. I think I would have needle fatigue if I had to inject every day or every other.

Oddly, I don't have any issues with daily injection. I expected to, fully expected to, but it's a part of my morning routine. But, you're right, had every 3.5 days worked, I'd have been delighted. All in the effort, successful, to manage E2 without an AI.

Lancealot · Nov 26, 2015

I can understand why one would inject every day to have more control over E to avoid an AI. That's great that you got it figured out CoastWatcher. Seems like its highly individual as far as protocols go and what works for each of us. I guess I was curious if he was having trouble with E or something else that caused him to switch to more frequent injections.