High Total T and Very low Free T

los407 · Mar 25, 2019

I am trying to figure out what to do. I have high Total T, LH, FSH, and Estradiol, but very low 0.45 ng/lL Free T. I just got my blood drawn for SHBG to confirm that the SHBG levels are high.

Is there an AI that will do a good job lowering SHBG? I read about something called AIFM (ATD), but have not been able to find any information about it online.

Testosterone, Serum 902 Range: 264-916 ng/dL 01
Free Testosterone(Direct) 4.5 Low pg/mL Range: 6.8 - 21.5 02
LH 15.1 HIGH Range: 1.7-8.6 mIU/mL 01
FSH 11.7 NORMAL Range: 1.5-12.4 mIU/mL 01
Estradiol 36.9 NORMAL Range: 7.6-42.6 pg/mL
Prostate Specific Ag, Serum 0.4 ng/mL 0.0 - 4.0 01

Thanks!!!

Systemlord · Mar 25, 2019

SHBG is next to impossible to manipulate, only excess androgens ~ TRT is only way to lower SHBG and increase Free T.

Cataceous · Mar 25, 2019

Indeed, an AI won't do much for you. Your high LH is suggesting that your testosterone production is maxed-out. Even if your estradiol result were confirmed via LC/MS, and even if all of it was prevented, this would raise total testosterone by only about 3.7 ng/dL. (Though reduced estradiol might help lower SHBG some). As @Systemlord says, you need TRT, or even TRT plus danazol.

Vince Carter · Mar 25, 2019

SHBG is likely skyhigh and as noted you can't directly manipulate SHBG in one direction or the other. I wouldn't think any one would touch you for TRT as the standard for HypoGonadal is much lower, 250(?) in TT. You might find a Dr that will treat you based on Free T but technically might not be able to make a medical diagnosis possible.

robson200 · Mar 28, 2019

I'm experimenting with proviron for lowering shbg. I will do a blood test very soon. If you remind me, I will give you an update

Deleted member 12831 · Apr 11, 2019

Direct testosterone for free testosterone is not accurate. Now, testing the total that way is accurate. and I am not sure what your shbg is. Danazol does lower shbg Here is a study on that. They compared doing testosterone alone and combined and danazol by itself, proviron. over month time. See what you think. Not sure if you still wanted comments or not . https://patentimages.storage.googleapis.com/41/bf/cb/06125864b44fcf/EP1079836B1.pdf