Elevated IGF-1 levels

[pyater]

Anyone else experience elevated IGF-1 levels after starting TRT. Still adjusting dosage after starting TRT on Feb 2019.

6 weeks labs

Elevated IGF-1 337

Just curious if anyone else has seen this.

 

[TLR]

Mine got up around 280, but the first time I ever had it tested I had been on for a year.

 

[MarcoFL]

Anyone else experience elevated IGF-1 levels after starting TRT. Still adjusting dosage after starting TRT on Feb 2019.

6 weeks labs

Elevated IGF-1 337

Just curious if anyone else has seen this.

what were they before you started?

 

[Dr Justin Saya MD]

what were they before you started?

+1

 

[pyater]

So started TRT with Test Cyp shots monthly in August 2018. No pre-TRT IGF-1 measurement at that point. Switched Dr.'s and protocols in February 2019.

Last Test Cyp shot was 12/19/18 (400 mg - every three weeks was protocol at that point). First IGF-1 measurement was 1/25/19 at 218 prior to switching.

Started new T cream protocol on 2/26/19 subsequent IGF-1 labs:
4/20/19 - 274
4/30/19 - 336

T levels and Estradiol - Sensitive were high with same lab work and protocol has been adjusted.

Total T - >1500
Free T - 41.5
Estradiol - Sensitive - 64.2

 

[pyater]

Anyone else experiencing elevated IGF-1 levels? My bounces around a bit. Endo just ordered a follow-up panel. Still seeing elevated levels from this prior post and have changes protocols see below.


Last reading (October) was:
IGF-1 - 324 ng/ml = Reference range for my age (81 - 263 ng/mL)
Total T - 503 –
Free T - 22.6 - Ref Range (6.8-21.5)
Ha1C - 5.5


Prior panel (July 2020) = Endo doesn't do a full panel and I am a few months from my Defy follow-up
IGF-1 - 269 ng/ml = Reference range for my age (81 - 263 ng/mL)
Total T - 636 –
Free T - 16 - Ref Range (6.8-21.5)
SHGB - 28.4
DHT-32
DHEA - 270
E2 - 33.1


Current Protocol - Since May - Switched from compounded cream
.35ml Test Cyp 200 mg/ml twice per week, no AI, no HCG, I do take DIM and CDC.

Thoughts, anyone else see this? I read all of the bad stuff about elevated IGF-1 and risks. I did have a pituitary MRI back in May of 2018 and it was clear. Have done a Glucose Tolerance test for GH and it was normal. There are some studies out there that show TRT increases IGF-1.

Effects of transdermal testosterone gel or an aromatase inhibitor on serum concentration and pulsatility of growth hormone in older men with age-related low testosterone - PMC

Growth hormone is the major regulator of growth and body composition. Pulsatile GH secretion declines exponentially with age. Testosterone replacement is being increasingly offered to older men with age-related low testosterone. Testosterone ...

www.ncbi.nlm.nih.gov