johndoesmith the next lab test was at 6 weeks and it was 32.5 E2 Sensitive. It was 8 weeks though before I really felt good again. Go figure. Maybe E2 has to be in a good range for a period of days or weeks to fully counter the effects of a crash? Just speculating here.
So at 6 weeks you measured E2, and 2 weeks later you felt better, or an additional 8 weeks after the E2 test?
I believe it's due to E2's effects being mediated mostly by nuclear receptors as opposed to G-coupled protein receptors, such as caffeine which elicits its effects via GCPRs.
Nuclear receptors cause action through mRNA, gene expression, and DNA transcription. These effects take more time to cause a change that is noticable than GPRC induced changes, such as caffeine, which is an adenosine antagonist. Adenosine receptors as an example, mediate their action through secondary messengers, and are much much quicker, within minutes they produce a noticable change.
Now E2 is also known to bind to GPRCs such as GPR30(G coupled protein receptor 30) which is known to cause rapid effects, like caffeine, but only some of estrogens effects are mediated through this receptor, it's believed to regulate the HPTA, which could explain why shutdown happens in days, not weeks, and makes sense as what good is a negative feedback system if it takes WEEKS to regulate hormone levels?
A few others, like vasodilation, and possibly water regulation in the body.
Hopefully that makes sense, all of this is correct to the best of my understanding and would love for
Dr Saya or someone else who knows more to proofread it.
