Best Ultrasensitive Estradiol Tests for Men

[Nelson Vergel]

Comparisons of Immunoassay and Mass Spectrometry Measurements of Serum Estradiol Levels and Their Influence on Clinical Association Studies in Men



"In conclusion, our findings suggest interference in the standard immunoassay-based E2 analyses, possibly by CRP or a CRP-associated factor. Although this interference does not seem to affect association studies between immunoassay E2 levels and skeletal parameters, we propose a reevaluation of previous association studies between immunoassay-based E2 levels and inflammation-related outcomes. In addition, LCMS-based assays are to be preferred for the quantification of E2 levels in men."

This is the most precise estradiol test for me provided by Labcorp:

Estradiol, LCMS (Endocrine Sciences)

[TABLE="width: 100%"]
[TR]
[TD="class: tableCell1, colspan: 2"]Test Number: 500108 CPT Code: 82670[/TD]
[/TR]
[TR]
[TD="class: tableCell1 detailsTitle, align: right"]Specimen:[/TD]
[TD="class: tableCell1"]Serum (preferred) or plasma, frozen[/TD]
[/TR]
[TR]
[TD="class: highlight detailsTitle, bgcolor: #BCD4EC, align: right"]Volume:[/TD]
[TD="class: highlight, bgcolor: #BCD4EC"]3 mL[/TD]
[/TR]
[TR]
[TD="class: tableCell1 detailsTitle, align: right"]Minimum Volume:[/TD]
[TD="class: tableCell1"]1.5 mL (Note: This volume does not allow for repeat testing.)[/TD]
[/TR]
[TR]
[TD="class: highlight detailsTitle, bgcolor: #BCD4EC, align: right"]Container:[/TD]
[TD="class: highlight, bgcolor: #BCD4EC"]Gel-barrier tube, lavender-top (EDTA) tube, or green-top (heparin) tube[/TD]
[/TR]
[TR]
[TD="class: tableCell1 detailsTitle, align: right"]Collection:[/TD]
[TD="class: tableCell1"]Serum/plasma must be separated from cells within 45 minutes of venipuncture. Send serum/plasma in a plastic transport tube. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.[/TD]
[/TR]
[TR]
[TD="class: tableCell1 detailsTitle, align: right"]Storage Instructions:[/TD]
[TD="class: tableCell1"]Freeze. Stable at room temperature or refrigerated for two days. Stable for two years frozen.[/TD]
[/TR]
[TR]
[TD="class: tableCell1 detailsTitle, align: right"]Methodology:[/TD]
[TD="class: tableCell1"]Liquid chromatography/tandem mass spectrometry (LC/MS-MS)[/TD]
[/TR]
[/TABLE]


This is the test performed by Quest Diagnostics:

Estradiol, Ultrasensitive, LC/MS/MS

Test Code

30289

CPT Code(s)

82670
Preferred Specimen(s)

0.5 mL serum collected in a red-top tube (no gel)
Minimum Volume

0.2 mL
Collection Instructions

Specify age and sex on test request form. Plasma, fluid and serum collected in SST's are not acceptable specimen types.Ship frozen. Do not thaw.
Transport Temperature

Frozen
Specimen Stability

Room temperature: 48 hours
Refrigerated: 7 days
Frozen: 2 years
Methodology

Liquid Chromatography Tandem Mass Spectrometry (LC/MS/MS)