There's a lot of good links on Twitter, but you have to wade through a ton of crap. This latest is a commentary from a doctor at Johns Hopkins.
Low testosterone levels in men were associated with an increased risk for vascular calcification in an age-adjusted analysis of data from the Framingham Heart Study, but not in an analysis that adjusted for conventional risk factors for coronary heart disease, such as body mass index and diabetes. The findings were published in the May issue of The Journal of Clinical Endocrinology and Metabolism.
The cross-sectional observational study included 1,654 men (mean age, 49 years) enrolled in the Offspring and the Third-Generation cohort of the Framingham Heart Study. Coronary, abdominal, and thoracic aortic calcification was measured using multidetector computed tomography. In an age-adjusted analysis, vascular calcification at all sites was negatively associated with total testosterone and calculated free testosterone, but was positively associated with estradiol and estrone levels (Table). For example, each 100-ng/dL between-subjects increase in total testosterone was associated with a mean difference in risk of coronary artery calcification of -23% (P=0.02). However, these associations between testosterone and vascular calcification were no longer statistically significant after adjusting for other cardiovascular risk factors.
Low testosterone levels in men were associated with an increased risk for vascular calcification in an age-adjusted analysis of data from the Framingham Heart Study, but not in an analysis that adjusted for conventional risk factors for coronary heart disease, such as body mass index and diabetes. The findings were published in the May issue of The Journal of Clinical Endocrinology and Metabolism.
The cross-sectional observational study included 1,654 men (mean age, 49 years) enrolled in the Offspring and the Third-Generation cohort of the Framingham Heart Study. Coronary, abdominal, and thoracic aortic calcification was measured using multidetector computed tomography. In an age-adjusted analysis, vascular calcification at all sites was negatively associated with total testosterone and calculated free testosterone, but was positively associated with estradiol and estrone levels (Table). For example, each 100-ng/dL between-subjects increase in total testosterone was associated with a mean difference in risk of coronary artery calcification of -23% (P=0.02). However, these associations between testosterone and vascular calcification were no longer statistically significant after adjusting for other cardiovascular risk factors.
