Palmitoylethanolamide (PEA)
A Comprehensive Review of Mechanisms, Clinical Evidence, and Practical Applications
January 2026
Abstract
Palmitoylethanolamide (PEA) is an endogenous fatty acid amide belonging to the N-acylethanolamine family with extensively documented anti-inflammatory...
I’m currently suffering from post finasteride syndrome and have been dealing with his affliction for over a year. My main dysfunctions are word finding problems and inability to have the same sexual arousal that I had prior to PFS. I took topical finasteride dosage of .25%. I wanted to my story...
Post-Finasteride Syndrome: A Complete Guide
Understanding the Persistent Side Effects of 5-Alpha Reductase Inhibitors
Curated By Nelson Vergel | ExcelMale.com | Updated January 2026
What happens when a medication prescribed for hair loss or an enlarged prostate causes symptoms that persist long...
It’s been almost a year since I started taking 400mg of pregnenolone a day in the morning on an empty stomach. I’ve tried different brands but settled on the Double Wood brand from Amazon for the price and effectiveness. Had a brief time where I tried stopping here and there and didn’t feel as...
Finasteride is what originally lead me to all of this. Reading into things more lately, I read some people saying that the presence of 5AR metabolites like DHT up regulate 5AR in a positive feedback loop. Does anyone have any knowledge or experience with this?
ABSTRACT
Background: An organic etiology underpinning post-finasteride syndrome, a constellation of persistent sexual, neuropsychiatric, and somatic symptoms reported by men exposed to 5-alpha-reductase inhibitors (5ARIs), is debated. Persistent changes in neurosteroid levels or androgen...