longevity

Cardiorespiratory fitness, as measured by maximal oxygen uptake (VO2max), is related to functional capacity and human performance and has been shown to be a strong and independent predictor of all-cause and disease-specific mortality. The purpose of this review is to emphasize age-related...

A protein that promotes inflammation could hold the key to a longer, healthier life. Blocking the protein, called IL-11, in middle-aged mice boosted metabolism, reduced frailty and increased lifespan by about 25%. The mice didn't just live longer, they were shielded from key signs of aging...

Hi all, Wondering if anyone has direct experience taking recombinant GDF-11 and/or Klotho. I have some on the way to test out and wanted to gather any information on experiences from this group.

https://www.mdpi.com/2076-3921/10/7/1035 Sellami M, Al-muraikhy S, Al-Jaber H, Al-Amri H, Al-Mansoori L, Mazloum NA, Donati F, Botre F, Elrayess MA. Age and Sport Intensity-Dependent Changes in Cytokines and Telomere Length in Elite Athletes. Antioxidants. 2021; 10(7):1035. Age and Sport...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295030/ Insulin, IGF-1 and longevity Diana van Heemst1,* Author information Article notes Copyright and License information PMC Disclaimer Go to: Abstract It has been demonstrated in invertebrate species that the evolutionarily conserved insulin...

The linked video has IMO a lot of great points that everyone who follows the developments in this area should be aware of. It's very relevant for the IMO over-rated concept of calorie restriction and the anti-Growth Hormone arguments, and lots of other topics as well:

Rilmenidine is a drug that is commonly prescribed to treat hypertension[2]. Recent studies have shown that rilmenidine can extend lifespan and healthspan in Caenorhabditis elegans, a type of roundworm, via a nischarin I1-imidazoline receptor[1][3][5]. The stress-resilience, health span, and...

I happened upon this while researching another topic. Interesting read. https://novoslabs.com/best-anti-aging-supplements-that-harvard-scientist-david-sinclair-takes/?utm_source=bing&utm_medium=cpc&utm_campaign=DSA-All-Pages&msclkid=77d21e9063511fceef3f7a7b0bbdf766 Nicotinamide mononucleotide...

I started taking about 500mg of NMN under the tongue, I am 36 years old on 120 mgs trt with 60 mg nandrolone and the occasional 250ius HCG eod. I take with TMG and keep it refrigerated. I work shift work some nights and have noticed a slight boost in energy. Although its only been a week and...

Hello all, Recently I have been eating more keifer, greek yogurt (lower sugar options) as well as Saurkreut. I hope to lower inflammation from fatty liver, working night shifts and high carb meals. I haven't gotten a baseline inflammatory marker blood panel but maybe Ill see some changes in...

Recently stumbled on a lot of interviews with longevity scientist and researcher David Sinclair. Many on YouTube. He is saying that research is showing that eating less and having longer periods of fasting activate genes that keep us younger and healthier. He is eating a mostly plant based diet...

Been on test and hcg for about 4 years. It's been a struggle at times and also very rewarding too. This platform is so helpful. I found there is no negotiations for me, when on TRT and needing to live a healthy lifestyle. Guys who are struggling to find the life force from test may want to...

Hi ExcelMale folks, I wanted to start off by expressing my gratitude for this site, all of the amazing work that has been put in to make this place such a great source of information. I would expect no less from a chemical engineer :). I've been following this "debate" about how to properly...

I see a lot of theories about optimum thyroid levels needing to be near the top of the typical T3 range and for TSH be near the low end of the range. But studies indicate for longevity, higher TSH levels nearer the high end of the range and lower thyroid hormone levels are indicated. I note...

Comhaire, F. TI - Hormone replacement therapy and longevity JO - Andrologia 2015 SN - 1439-0272 To assess whether hormone replacement therapy influences longevity, an analysis was made of published life tables allowing for the calculation of the relative benefit of hormone replacement...