genetics

In this episode, Dr. Donovan takes a deep dive into frontal fibrosing alopecia (FFA), one of the most fascinating and challenging conditions in modern hair medicine. First described only a few decades ago, FFA has rapidly become one of the most common forms of scarring alopecia seen in hair...

Society for Endocrinology Clinical Practice Guideline for the Evaluation of Androgen Excess in Women Guideline summary https://www.excelmale.com/threads/laboratory-evaluation-in-pcos-pmos-improving-accuracy-interpretation-and-standardization.34806/...

Learning Objectives Take Home Points

https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/dom.16612 Abstract Aims Nearly 42% of adults in the United States have obesity, a significant risk factor for many cardiometabolic diseases and cancers. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are promising...

* Lp(a), a low-density lipoprotein (LDL)-like particle with an apo(a) attached to apoB molecule, is now recognized as a potent genetic risk factor, with levels above 50 mg/dL (125 nmol/L) linked to cardiovascular complications, including myocardial infarction, stroke, aortic stenosis...

https://www.nature.com/articles/s41467-023-44681-2 https://www.psypost.org/neuroscience-harvard-scientists-just-revealed-a-remarkable-fact-about-brain-development/ “In the age-old question of nature versus nurture, we land decisively on the side of nature,” Barabási told PsyPost. “We challenge...

Hi all, Wondering how much genetics plays a role in secondary sex characteristics vs total testosterone levels. I read a paper (attached) which shows that professional athletes have testosterone levels around 500-600ng/dl, which is around my levels but i have very poor secondary sex...

Supernumerary sex chromosome abnormalities – new developments and future trajectories - A summary of the 2022 3rd International Workshop on Klinefelter syndrome, XYY and Trisomy X Claus H. Gravholt, Alberto Ferlin, Joerg Gromol, Anders Juul, Armin Raznahan, Sophie van Rijn, Alan D. Rogol, Anne...

Nothing new per se but it's a nice summary. Also ventures into genetic predispositions. https://selfhacked.com/blog/hematocrit/

Genetic architecture of human thinness compared to severe obesity

Several studies have been published on the subject of genetic predisposition to certain side effects of testosterone. Here is the latest The role of the androgen receptor CAG repeat polymorphism and other factors which affect the clinical response to testosterone replacement in metabolic...