The occurence of fractures in an elderly population is a significant concern, so this study looked at the relation between the number of fractures and hormone levels, including testosterone. It found fractures were higher at both low and high levels of endogenous testosterone:
"Analysis of...
https://academic.oup.com/jcem/advance-article-abstract/doi/10.1210/jc.2018-00934/5094017?redirectedFrom=fulltext
Evidence of a Causal Effect of Estradiol on Fracture Risk in Men
Context
Observational studies indicate that serum estradiol (E2) is more strongly associated with bone mineral...
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