acne; pathophysiology; treatment; sebum

This ones going out to all those bros stinkin' up those so called HRT/men's health forums! Stop f**king blaming high estradiol! Critical points here! * The four established pillars of acne pathogenesis are sebum production, follicular hyperkeratinization, Cutibacterium acne (C. acnes)...

ABSTRACT Background Sebum physiology and its contributions to acne vulgaris (AV) pathophysiology have been long debated. Within the pilosebaceous unit, androgens drive sebocyte production of sebum, comprising mono-, di-, and triglycerides (the latter converted to fatty acids); squalene...