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If DHT isn't tested, impossible to say. But I haven't heard that low estrogen (without an ai) causes "spaciness." I've heard the exact opposite: higher DHT improves thinking. That's what Hans Amato talks about.

Right. My suspicion is that they are comparatively low. If you were "locked in," I would guess higher DHT (relative to just T levels). "Spaciness" I wonder is relatively low DHT. Just speculation.

I'd be curious to know what DHT levels are at peak "spaciness."

From Georgi Dinkov: https://haidut.me/?p=2747

If you're feeling anxiety, it could be the result of the low or slow MAO-A gene, which can result in an imbalance of serotonin to dopamine. Basically serotonin is too high. If that is a factor then the solution could actually be to use whatever exogenous T you are using in a MORE in pulsatile...

Ray Peat on why "normal" thyroid function is misleading based the arbitrary determination that only five percent of the population was hypothyroid.

You wish it was lower as a result of cardiac fitness or lower because you subscribe to the rate-of-living theory?

It broad terms, it is suboptimal energy production from various causes including in large part consumption of PUFA. Burning glucose primarily (not entirely) through oxidative phosphorylation is the most efficient method (i.e. produces the most electrons for ATP). Bioenergetics rejects the rate...

Sure, that's what conventional wisdom would say. What Danny is saying is that the combination is indicative of hypothyroidism. From Roddy: "Prolonged cortisol excess and adrenaline can lower TSH" — Ray Peat "Aging, infection, trauma, prolonged cortisol excess, somatostatin, dopamine or...

Here's a post on X.com by Danny Roddy discussing the bioenergetic interpretation of high cholesterol, low TSH, low blood estrogen with high testosterone, and high SHBG.

I would look into increasing magnesium and potassium consumption. Magnesium by way of drinking magnesium bicarbonate following Dr. William Davis's protocol. If you search his podcast and articles, you'll find his explanation on how he treated patients with magnesium deficiency. Also look into...

Have you changed the way you eat in light of the Tesamorelin? The conventional advice is to take it at least 90 minutes away from food. If you were used to eating any carbs before bed, it is possible that it is not the Tesamorelin itself, but the fasted state. You might see what happens if...

No. I have used Magnoil, which is magnesium (either L-pidolate or sulfate) and DMSO. It works great. However, I understand in recent years there have been reassessments about the use of DMSO in compounds. I know some people experience skin irritation, but I've never had that happen. I am not...

I'm not going to keep doing this, but here is Georgi Dinkov (timestamped) discussing his self-funded research regarding pro-metabolic treatment of cancer in mice. Again, from the "bioenergetic" perspective, Georgi talks about lipolysis in cancer metabolism, the similarity between Type 1...

Not trying to win any debates, but for the thread and posterity, here is a time-stamped link to Jay Feldman in a recent interview giving the bioenergetic explanation of the energy benefits of glucose metabolism for the brain.

Paul Saladino ate carnivore and switched to a bioenergetic diet for the same reason I did. "Correctly" means anyone who does the diet, but does not get the results you expect didn't do it correctly. That's a rhetorical trick. I don't think you understand that you can eat Lion, Carnivore, or...

Those diets avoid autoimmune reactions and inflammation, but they don't avoid hypothyroidism for the precise reason we're discussing. They are not energy efficient over the long term.

@Gman86 - As I think I've mentioned to you, I did low carb / keto for 22 years. I "walked the walk." The vast majority of time, my carb consumption was very low. Less than 30 grams a day. When I did consume carbs, it was from mostly fruit. I saw the benefits. I think eating that way resulted...

Peat's concerns about estrogen aren't to be confused with the misguided use of aromatase inhibitors for those taking exogenous Testosterone. Peat was right about excessive estrogen. And of course all the hormones are important, as noted in this thread, including cortisol and estrogen. But our...

He understood that human health is based on optimal energy production. For instance, cancer is at its core metabolic disfunction. Peat wasn't perfect, but he had deep insight into human health. What from 20 years ago makes you "still think he is a lunatic"? I certainly didn't encounter his...

@Gianluca I just saw this from Danny Roddy on Substack re Progesterone. I don't think it is paywalled. Not sure how the link will appear here. https://substack.com/@dannyroddy/p-145295143

Yes. Clean hands. One drop the size of a kernel of corn to the index finger and massage into gums. I think the pad of the finger is calloused enough that it is going into the gum and not the finger!

It does sound like you are quite active, which is great. It is safe to assume you are not lifting heavy if you are working out seven days a week at age 55 and are 5'8", 155 lbs. I don't know anyone that would endorse a 7-day week weightlifting schedule at age 55. How did you lose the weight...

No I have not. I only started that when Mercola mentioned it recently. And I've only used a "kernal" sized dose up to twice a day--the 3 mg Prog / 1 mg DHEA.

Usually before bed. Sometimes late afternoon if I can sense higher "physiologic stress." Never in the morning. I might do it in the morning with some kind of acute illness, but I don't want to interfere with morning cortisol.

That is very helpful. Something to keep in mind because it is so easy to misconstrue "paradoxical" effects based on dose-response.

Dr. Mercola is difficult to pin down because he's constantly "refining" (i.e. changing) his opinion. Here Dr. Mercola argues for "transmucosal" application of progesterone. He says transdermal results in high levels of 5-alpha reductase which converts progesterone into allopgregnanolone. I've...

"Progesterone, pregnenolone, T, and DHT are all within the group of steroids with anti-cortisol effects and a drop in the levels of any of them contributes to a relative increase in glucocorticoid signaling." http://haidut.me/?p=912 Again, I'm not that knowledgeable, but I've heard the...

I don't have the knowledge many of you have about prog, but Georgi Dinkov asserts that certain adverse effects of progesterone in men can be offset by combining it with DHEA. It is clear that Progesterone has great anti-catabolic (anti-cortisol) effects. Take enough of it, and you'll feel like...

No doubt someone more knowledgeable will weigh in. Tesamorelin costs less--about half the cost I would estimate. If your pituitary gland is incapable of producing growth hormone due to a tumor / damage, then Tesamorelin won't be effective. Conversely, taking exogenous HGH shuts down production.