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No. I have used Magnoil, which is magnesium (either L-pidolate or sulfate) and DMSO. It works great. However, I understand in recent years there have been reassessments about the use of DMSO in compounds. I know some people experience skin irritation, but I've never had that happen. I am not...

I'm not going to keep doing this, but here is Georgi Dinkov (timestamped) discussing his self-funded research regarding pro-metabolic treatment of cancer in mice. Again, from the "bioenergetic" perspective, Georgi talks about lipolysis in cancer metabolism, the similarity between Type 1...

Not trying to win any debates, but for the thread and posterity, here is a time-stamped link to Jay Feldman in a recent interview giving the bioenergetic explanation of the energy benefits of glucose metabolism for the brain.

Paul Saladino ate carnivore and switched to a bioenergetic diet for the same reason I did. "Correctly" means anyone who does the diet, but does not get the results you expect didn't do it correctly. That's a rhetorical trick. I don't think you understand that you can eat Lion, Carnivore, or...

Those diets avoid autoimmune reactions and inflammation, but they don't avoid hypothyroidism for the precise reason we're discussing. They are not energy efficient over the long term.

@Gman86 - As I think I've mentioned to you, I did low carb / keto for 22 years. I "walked the walk." The vast majority of time, my carb consumption was very low. Less than 30 grams a day. When I did consume carbs, it was from mostly fruit. I saw the benefits. I think eating that way resulted...

Peat's concerns about estrogen aren't to be confused with the misguided use of aromatase inhibitors for those taking exogenous Testosterone. Peat was right about excessive estrogen. And of course all the hormones are important, as noted in this thread, including cortisol and estrogen. But our...

He understood that human health is based on optimal energy production. For instance, cancer is at its core metabolic disfunction. Peat wasn't perfect, but he had deep insight into human health. What from 20 years ago makes you "still think he is a lunatic"? I certainly didn't encounter his...

@Gianluca I just saw this from Danny Roddy on Substack re Progesterone. I don't think it is paywalled. Not sure how the link will appear here. https://substack.com/@dannyroddy/p-145295143

Yes. Clean hands. One drop the size of a kernel of corn to the index finger and massage into gums. I think the pad of the finger is calloused enough that it is going into the gum and not the finger!

It does sound like you are quite active, which is great. It is safe to assume you are not lifting heavy if you are working out seven days a week at age 55 and are 5'8", 155 lbs. I don't know anyone that would endorse a 7-day week weightlifting schedule at age 55. How did you lose the weight...

No I have not. I only started that when Mercola mentioned it recently. And I've only used a "kernal" sized dose up to twice a day--the 3 mg Prog / 1 mg DHEA.

Usually before bed. Sometimes late afternoon if I can sense higher "physiologic stress." Never in the morning. I might do it in the morning with some kind of acute illness, but I don't want to interfere with morning cortisol.

That is very helpful. Something to keep in mind because it is so easy to misconstrue "paradoxical" effects based on dose-response.

Dr. Mercola is difficult to pin down because he's constantly "refining" (i.e. changing) his opinion. Here Dr. Mercola argues for "transmucosal" application of progesterone. He says transdermal results in high levels of 5-alpha reductase which converts progesterone into allopgregnanolone. I've...

"Progesterone, pregnenolone, T, and DHT are all within the group of steroids with anti-cortisol effects and a drop in the levels of any of them contributes to a relative increase in glucocorticoid signaling." http://haidut.me/?p=912 Again, I'm not that knowledgeable, but I've heard the...

I don't have the knowledge many of you have about prog, but Georgi Dinkov asserts that certain adverse effects of progesterone in men can be offset by combining it with DHEA. It is clear that Progesterone has great anti-catabolic (anti-cortisol) effects. Take enough of it, and you'll feel like...

No doubt someone more knowledgeable will weigh in. Tesamorelin costs less--about half the cost I would estimate. If your pituitary gland is incapable of producing growth hormone due to a tumor / damage, then Tesamorelin won't be effective. Conversely, taking exogenous HGH shuts down production.

Last point. To be clear I am not suggesting one should artificially lower estrogen. I am referring only to exogenous estrogen supplementation. I hope your spouse knows why it is being prescribed. If it is to treat symptoms of menopause or osteoporosis respectfully I believe that is a huge...

I have a bias, but one based on experience. I give weight to the bioenergetics / Ray Peat perspective. https://www.jayfeldmanwellness.com/ep-40-why-estrogen-and-birth-control-are-not-the-solution-womens-hormonal-health-part-1/

What is the reason for taking estrogen other than the doctor is terrible? Have her find the doctor who will advise her to stop the exogenous estrogen and start taking progesterone.

From Jay Feldman

That makes sense because propranolol and metaprolol are known for impairing melatonin production.

The conclusion seems axiomatic. In patients diagnosed with heart failure with preserved ejection fraction (a distinct subset of heart failure patients), withdrawing beta blockers resulted in short term increased exercise tolerance. I can't see the underlying study design to discern what...

Supposedly co-administration of oral GABA and vitamin B (B6?) increases ability of the GABA to cross the BBB.

It kind of makes sense. Think of the options. 1. normal sunlight; 2. synthetic sunlight; and 3. synthetic hormones. You're doing #3, but SHOCKED that a person would do the second option. The problem with just supplementing D3 is that you're going for balance. It's not all upside. The...

I have found it much easier to control Vitamin D with a UVB lamp rather than supplements. That would be the Sperti Vit D lamp. Alternatively you could build your own.

More evidence that increasing omega-3 increases inflammation. http://haidut.me/?p=2520 https://bmjmedicine.bmj.com/content/3/1/e000451

One other option is magnesium bicarbonate. Dr. William Davis explains how to make Magnesium Bicarbonate which is easily absorbed. Unfortunately almost all Milk of Magnesia now contains sodium hypochlorite. The solution is to buy magnesium hydroxide (I buy from Bulk Supplements) and just add the...

So Vitamin C increases absorption of non-heme iron. Therefore supplementation of Vitamin C with a high carnivore diet would not be the issue. But I ate vegetables too, so the Vitamin C could have been a factor. Here's Chris Masterjohn again. The link gets paywalled in about 36 hours...

Chris Masterjohn PhD just wrote a piece about ferritin in his Substack. Am posting below, but I'm not 100% sure it is not behind a paywall. The gist of what he writes is there's still much we don't understand about serum ferritin. Seems a bit of an understatement...