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Restarting the HPTA axis. I ended up not needing it. Btw, my website is back up and running. There I share my experience & takeaways from years of hormone replacement: Hormetheus.com

I apologize for the website having been offline for almost a year. Website is back up and running. I share my articles, thoughts, and protocol there: Hormetheus articles

I am glad that you found value in my article. Personally, i need 1mg, whereas my friend is fine with 0.25mg. All of us have a different sensitivity to things. Furthermore, I am a lot lower in bodyfat compared to my friend. GLP-1 agonists are leptin sensitizers. The more body fat you have (= lots...

Hey, yeah Hertoghue is not up to date on hormone treatment. However, his approach of replacing multiple deficient hormones at the same time is great and not something that is done by conventional medicine

I have written about my experience with semaglutide here: The Simulated Refeed I also share some tips and tricks and observations while using semaglutide. Never has a drug made as much of a difference for me.

Yes it is incredibly safe. I describe my experience in detail in my new article The Simulated Refeed

Still effective for me. I describe my experience with it in detail soon with a new article I will post on my website. You may sign up for my newsletter to get notified when it is available. In there you´ll find in-depth the things I have noticed

It depends on whether your low T is due to lack of satiety signals or not. Yours obviously was not

Best drug I have ever tried. Still on it and if possible I will never come off :) Hormones are back to normal (and much else improved)

However, I have heard good things from Thierry Herthogues clinic.

I get private prescriptions and do it all myself. Though I am a final year med student and by July I´ll have my licence

Hey, the more I follow all of this and people on TRT it seems it is a very common experience that people feel great for some time but then many return to feeling shitty again... Many try thyroid and adrenal replacement. Same thing. The honeymoon period does not last (at least for many). To me...

Hello, yes, my problem is likely hypothalamic (POMC neurons), which can be remedied by targeting these neurons using e.g. semaglutide. No, I take the injectable and it cost me 140$ per month, however it is worth it. No, stims do increase cortisol acutely, but it is very unlikely that they...

Given that your low T is of hypothalamic origin (mainly POMC-neurons mediated), then yes. Yes, it is far safer than almost all other drugs out there, as it is basically a benign hormone (acting on GPCR instead of nuclear receptors as do steroid hormones). Also, it is certainly worth a try and...

I came off testosterone using semaglutide. My T levels doubled twice within 4 weeks. I am now somewhere in the 500s. A friend of mine had diet-induced low T. Using semaglutide without dietary changes his LH/FSH multiplied and T levels doubled. Also, your study is exactly the problem: It does...

Well, it should not be too hard to find. Google "GLP-1 and LH/FSH" or "GLP-1 and POMC neurons". It actually does cross the blood brain barrier as there is a receptor for it. Furthermore, it can act on brain stem and hypothalamic areas at the circumventricular organs

Have you tried semaglutide (ozempic)? It also kickstart hypothalamic pathways - esp. if "damage" to hormonal axes was done by undernutrition/overtraining etc.

Unfortunately not much. However, what we can say is that at the level of the hypothalamus the releasing hormones (e.g. GnRH, CRH, etc.) are also transmitted into the nervous system. Furthermore, various tissues have receptors for stimulating hormones (e.g. LH-receptors in the adrenal glands, TSH...

Yes, surely the effects of endogenous levels are different compared to the same results achieved via exogenous hormones

RR: 120/70 Sleeping HR: 50 RHR: 60 They are actually now higher compared to what they were before, the reason being I added semaglutide which elevated my HR by 10 or more. Whenever I need a stim, I take very small doses of ephedrine (i.e. 4mg -which is a very very small dose), which I like...

FAQ I often get: Can I measure my cortisol with saliva or urine tests? Yes, saliva and urine can be helpful for intra-individual comparisons, however, interpreting them in terms of where one falls in relation to others, should be taken with a huge grain of salt, in my opinion

Generally, cortisol is incredibly hard to test for. I have seen an elevated cortisol many times in total cortisol, but often CBG is high. Generally, a good indicator of adrenal health is DHEA-S. Other than that, in my experience, urinary and salivary cortisol are not worth much. The best may...

Hell. Yes, I do regularly monitor my vital signs. Around 4 months ago. Now I just use the occasional 3-5mg of HC when I need it (e.g. 2x per week). When I feel run down, I do use modafinil usually (30-50mg)

Yes, glad my hypothalamus was never damaged in the first place (which it certainly might be for some people!). I have reduced thyroid to 75mcg T4 only a few days ago. I feel a little tired and cold as hell. Will stay at that dose and get another blood test in 2 weeks to see whether my TSH...

Update: I have now been off the GH and the cortisol for 5 months. I just got my blood results. After weaing off GH and cortisol, these two axes are now at higher levels than they were before. On this weeks blood test ACTH was at the 85th percentile (very pulsatile so take it with a grain of...

Hello, currently I am on just thyroid hormones. Will do a blood test this week to see where my levels are at and then go from there. Perhaps trying a short course of clomid, if levels are low.

Hello, getting pharma grade GH is doable, but getting it prescribed is much harder.

Hello, I can promise that over the long term you are running into problems with this protocol (likely). Also, your thyroid is way too high (at least judged on the dosage). And you running this much exacerbates your issues. I feel uncomfortable making specific suggestions here on an open forum...

Yes, I believe this to be true as well. It should be noted though, that the reverse is also true for some (esp. if hormones are abused at high doses): namely, although rarely, some people do not recover their baseline hormones at all

Update: After using HC for around 2 years, I was able to get off the HC, effectively resetting my HPA-setpoint to a higher baseline. I have now been off all HC for 4 months and I feel perfectly fine. Also, HC is the most dangerous, difficult, and most cumbersome hormone to replace so I am glad I...

Thanks for the info! For me though, likely as I was using much lower doses, recovery was almost "instant", without any transient period of (symptomatic) hypocortisolism. I have a question for you, as you seem incredibly experienced and knowledgeable: I have heard recommendations to try small...