Search results

Injecting everyday sustanon wouldn't be too much different than enanthate or cypionate - definitely not enough to be the difference between feeling awful or amazing. What was your protocol on sust? Everyday injections can work well.

One of the roles of HCG during pregnancy is to shift the mother's cellular metabolism away from glucose and towards fatty acids - all in order to preserve the former for the developing foetuses brain, as glucose is requite for brain development. One of the hallmarks of cancer - also denoted...

Some more information I've come across from Dr Raymond Peat on the influence of progesterone and estrogen on water retention - from his book, 'From PMS to Menopause': "In animal experiments, I knew that estrogen causes cells to take up water within a few minutes after it reaches the tissue, and...

I also use Ovidac and implement the exact same reconstitution method as Blackhawk. The price of HCG is ludicrous now - with my prescription it costs £128 for a three months supply, whereas importing from overseas costs £35 for the same period.

This was my experience with TRT, too. On weekly injections I always found that I felt the best a day or two before my next shot was due, around 650 ng/dl. Then, a day or so after my next injection when levels hit > 1000 ng/dl, erections and libido would disappear again, water retention would go...

Apologies if you specified elsewhere, but which particular intervention do you feel made the biggest difference? I've seen you're taking / have taken GnRH, progesterone, hcg, clomid, test p/cyp blend and a few other things, so I'd be curious to hear which one was most impactful.

That's brutal. I've read several reports of success using both enzymes in question — I wonder whether the reaction was specifically to the enzymes themselves, or to a potential additive and/or impurity in whatever mixture they injected.

Progesterone dissolved in alcohol. I've bought their cortinon before (progesterone and dhea dissolved in tocopherol) with no issue. Everything is advertised as 'for lab research', but that's solely to get around having to be a registered pharmacy since they're selling restricted hormones. I...

I stopped trt because it made the vast majority of my existing issues worse, as well as contributing various issues of its own. I took it for four years, with bloods and protocol adjustments every twelve weeks, so I gave it plenty of time. The protocol rarely made a difference in how I felt. I...

12.8 pmol/l is very low, but how do you actually feel apart from the fatigue? Do you have symptoms of low thyroid function, like: low body temps, thinning hair and/or eyebrows, impaired digestion, dry skin, etc? Thyroid treatment alone is less inconvenient than trt in my opinion, so there'd be...

Crisler recommended transdermal over oral because it skips the first pass of the liver, which is responsible for much of the pregnenolone -> progesterone conversion; transdermal skips the first pass, seemingly increasing preg sulfate and the androgens more than prog and the progestins...

That's a strange one. I'd have expected the opposite since it's an antagonist of the AR and a potent inhibitor of testosterone -> dht via 5ar — there's even a few threads floating around on hairloss forums where people have used it to regrow hair. Did you notice any positives in terms of...

I use progest-e as the ingredients are nothing more than bio-identical progesterone suspended in vitamin e. I've had issues in the past with certain creams containing unpleasant herbs that aren't disclosed on the label (for example, now foods progesterone cream also contains saw palmetto), so I...

Prolactin is very elevated, but it's always in-response to testosterone and hcg, so it's primarily mediated by an increased is systemic estrogenic load. You are correct that thyroid and adrenals are hard to treat in terms of practicality, but that doesn't bother me too much because impaired...

Not really. Never looked at TBG as it's a pointless test, but total T4 has always been extremely low despite free t4 / 3 being somewhat normal. Raising total T4 with levothyroxine and low-dose T3 always causes a significant increase in body temp and overall wellbeing until cortisol levels drop...

-

The trt-induced adrenal suppression involved below range serum am cortisol, low four-point saliva cortisol across the day, undetectable progesterone and below-range DHEA-S — all of which return to normal following the cessation of testosterone. Taking thyroid hormone has a similar suppressive...

Unfortunately HCG never did anything for my upstream or downstream hormones. I've run up to 500iu EOD alongside trt and also as a monotherapy, yet my cortisol, progesterone, 17-OH Prog and DHEA were always below range; coming off trt restores all four to normal. It did, however, send my...

All the standard things — low energy, exercise intolerance, morning fatigue, inability to build muscle mass, brain fog, low sex drive and regular ed. TRT didn't do anything to improve any of the above apart from increased muscle mass; it actually made many of them worse due the...

Considering levels of DHT remain normal the entire time a man is on trt, I find it far more likely that the development of anxiety Gordon discusses is due to a deficiency of substrate for 5ar, rather than an issue with the enzyme itself. Progesterone -> 5a-dihydroprogesterone via 5ar precedes...

Supplemental progesterone makes my trt-induced water retention immediately melt away. For those unaware, Ray Peat has done an enormous amount of work on the interaction between estrogen and progesterone, and his model explains exactly why a disturbed balance in-favour of estrogen would result...

Indeed. Before the development of the thyroxine blood test, cholesterol levels were used as an indirect biomarker of low thyroid function, as T3 controls the rate of systemic cholesterol -> pregnenolone production, among other cholesterol-derived substances. Unfortunately most physicians have...

Anecdotally, my hypothyroid symptoms - low body temps and pulse, fatigue, dry skin, digestive issues, etc - have always correlated with my fT4 and total T4, even when fT3 was top of the range, and TSH was within range, but slightly elevated. These symptoms started following an extended period of...

Medroxyprogesterone acetate is nothing like bio-identical progesterone, so their effects cannot, and should not, be compared — it actually has various anti-progesterone effects in the tissue through it's competition with progesterone for the PR. Rouzier and Nichols et al love to discredit...

I had/have very severe anxiety on trt, manifesting as a chronically pounding heart, racing thoughts, regular adrenaline surges and daily panic attacks — none of which were present pre-trt; all of which go away when I come off testosterone. One thing that always correlated with the above is my...