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Do any of you know.. if one takes exogenous GH, how soon IGF-1 levels drop to baseline after stopping? @Cataceous

@Nelson Vergel have you considered doing something about that Ferritin? Not relevant in your case, but I've seen a study on hypothyroid women who remained symptomatic until ferritin >100. Secondly, have you ever tested your GH or had a GH stimulation test?

Do you know of a way to get prescribed growth hormone in Europe?

I'm currently taking TRT, HC, T4 and T3. Are you still replacing growth hormone?

Has any one of you guys been on growth hormone and know your pre- and post IGF-1 labs? What source did you go through and did you notice a difference? I found out my IGF-1 is well on the lower end, consistently. But not enough for treatment. @Nelson Vergel @Cataceous

The beard DP cells appeared to generate more 5α-DHT than those from nonbalding scalp hair follicles (Thornton et al, 1993)

Northern blot studies revealed most abundant type 1 mRNA in neonatal foreskin keratinocytes, followed by adult facial sebocytes, and stronger expression in DP from occipital hair cells than from beard (Chen et al, 1998a).

"In the skin the activity of the type 1 5α-reductase is concentrated in sebaceous glands and is significantly higher in sebaceous glands from the face and scalp compared with nonacne-prone areas (Thiboutot et al, 1995)."

"Thus, the present study demonstrates that the 5α-reductase activity is mainly located in the apocrine sweat gland and sebaceous gland. This suggests that 5α-reduction of testosterone is an important step in mediating the action of androgens in these tissues." This is interesting. I'd guess the...

Hi all, Wanted to know if anyone knew this. I'm aware that likely genital skin/scrotum is richest in 5a-reductase and thus yields the most DHT from topical testosterone (gel or cream). Does anyone know which site comes after that? From what I've read the sheer amount of skin you apply on...

If anybody's wondering whether this can be done without burning.. I've tried pouring a thin layer of testosterone gel onto aluminum paper, let it stay out for around.. 2-3 hours, then apply to the balls. The idea is to let some of the ethanol evaporate. And why I do this.. I can't get the...

Really? What's the process like/what do you do with it after?

@Cataceous I also wonder if testosterone gel can be reduced into powder.. and if I could blend this myself, less of a hassle, lol. Composition of one bag of gel: Testosterone 50mg, Carbomer 980, isopropyl myristate, 96% ethanol, natrium hydroxide, distilled water

@Jason Sypolt

Hi, There is a compounding pharmacy where I live but they don't know how to make testosterone cream. Does anyone have a formula / composition that I can send to them as reference?

I seem to tolerate both very badly. I do well with cottonseed oil. I get severe asthma-like symptoms from these. My situation is that I ran out of my Rx (which uses cottonseed oil) and I need a substitute as the clinic provides something to bypass Brexit

I don't want to be rude but it seems rather strange to assume that it works like this for every human being in existence. But I suppose it is a nice rule of thumb.

The total testosterone was as I mentioned, the SHBG was a bit over the range, but so was FT. The protocol is EOD, both the anastrozole and the testosterone. E2 was 15 pg/ml, I'm willing to let it climb to 30, so I will reduce the anastrozole dosage. The trough level before at the same dose was...

Isn't this weirdly much? What confuses me is when I switched to this dose at first it went significantly lower. Should I try 80mg/wk?

I've been experimenting with this a bit and I'm finding that I can tolerate a fairly high dose of T3. 100 mcg/d spread out over the day with 50mcg Levothyroxine seems to go well somehow..as in, I feel well. If it's not spread out enough I would feel slight hyperthyroid symptoms.

Ahh okay well done. I'm so impatient. Btw I sleep with a CPAP machine for sleep apnea. It measures my events per hour. Very interestingly I never get < 0.9 events per hour (and usually not more than 2.4). However afte rthe first night with T3 (I took 12.5mcg at 6 PM) I slept for 9 hours with...

Did you ever have a problem with over dosing T3? I.e. does it ever make you feel uncomfortable? It gets rid of every ounce of fatigue for me. If anything it might be doing a bit much. I guess.. I will figure it out with time. Also has to do with eating properly and exercising.

From the graph here I'd expect maybe minor improvements from adding a second dose at... 6 hours. No way to know without measuring, this was a 50mcg dose they tried: Single Dose T3 Administration: Kinetics and Effects on Biochemical and Physiologic Parameters

Thanks Vince, you've been very helpful. I haven't felt so well in a long time. Apparently, if I'm reading correctly, the absorption of T3 is typically about 90%, with a peak concentration occurring within 2 hours and a half-life of 19 hours. So I would guess that a once a day dosing would be...

To elaborate on this. I feel an onset where I'm more sharp, happier, more social. Then almost a crash where I feel less.. of that. But not horrible.

Interesting. I took 12.5 mcg at 5.. at 7 I felt the onset very much and until 10-10:30. I'm still fine but I feel it wearing off. Do you never feel the need to take some in the middle of the day?

Oh I didn't realise you'd switched. What are you on currently? I took my first 12.5 mcg of Tiromel earlier and it is like the fog has lifted. I feel a potent antidepressant effect, just as I did with the first week of T4.

Btw @Vince I'm trying to gauge your T3 doses. "6.25 MCG of pure T3 twice a day, giving us 12.5 MCG/d along with 90 mg armour. " 60mg Armour (1 grain) contains 9mcg, so that's another 12 there. Along with 38 mcg T4 per 60mg gives us 57mcg T4. The doctor I spoke to suggested a similar dose...

Only before Levothyroxine. FT4 was low, TSH was only very mildly high, and the TPO antibodies were elevated. I finally got some Tiromel, am looking forward to trying it out.

I'm still not sure if I could legally purchase that. I believe I need a script (sadly). What I can do currently is try to increase my Levothyroxine dose. It's just annoying that I felt such clear benefits at the start that seem to have disappeared. I feel like I would get them with T3...

Does anybody know of a doctor or a clinic in any country within the EU that prescribes this?