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Cataceous, have you tried GDF-11 or klotho? The data/evidence on GDF-11 is weak/conflicting. Klotho seems to have a quite a bit of evidence that it would be beneficial. How did you arrive at your GHK-Cu dosing?

Your E2 isn't high. You could try a microdose of anastrozole to shift your test/e2 ratio. I only take 30 mcg with each injection. However, the symptoms you describe don't seem to be associated with elevated E2. If you had water retention, the lasix would have resolved it. You're not loosing...

If he had never tried a lower dose, I would agree with you. But it sounds like he already went through titration with his previous physician and knows that it takes 180 mg/week to resolve his symptoms. Just because someone is taking a higher dose than most need doesn't mean it's inappropriate...

No, that's not a clear case of high e2. Although low libido can be caused both by E2 being too high or too low. You didn't mention irritability which is another symptom of high e2. Like I said in my previous post. Drop the AI and drop your T dose and see how you do.

I would try to find a dose that works for you without an AI first. Start at 60mg twice a week. Give that 8 weeks and see how you feel. If still having symptoms, try increasing by 10mg (70 mg/twice a week). If things improve but still have some symptoms go up by 10mg again. If things improve...

I don't have a good answer. The only thing I can suggest is to look at each Urologist's background and see if they mention a residency or fellowship in Lipshultz's clinic. He usually has 2 research fellows and 2 clinical fellows every year, plus who knows how many residents. Each lab has...

Try a local urologist. In general urologists are more informed than other medical specialities with TRT. If you're in a major metro area look for a urologist that did a fellowship at Baylor in Houston under Lipshultz or Harvard in Boston under Morgentaler. If you're unable to find a good...

If this is your first time trying a keto diet and are serious about staying in ketosis, you should assume that anything that is processed will knock you out of ketosis until proven otherwise. The first time I tried keto, I had problems with breakfast and couldn't figure out what was causing my...

Why only use the deltoids? Include more sites in your rotation if you're concerned about long term scar tissue.

Irritability when E2 gets too high. Anastrozole's effectiveness varies by individual. Small amounts may be all you need to control high E2 symptoms. I only take 63 mcg per dose.

The amount of carbs and protein that allow you to maintain a blood level of ketones >0.5 mmol/L. Carbs have a bigger effect than protein on ketone levels, and for most carbs will need to be <50g/day to reach this level of ketones. For some carbs will need to <20g/day to reach this level of...

I don't know how much this will actually affect results. The size of the error matters. From the methodology of the first study: Huge quantities of esterified testosterone were directly added to the serum in order produce a large error effect in the testing.

Agree with most of the above. A carnivore diet can be ketogenic, but typical grocery store beef cuts are too lean. The ideal cut is untrimmed ribeye. Not a cheap diet... When I experimented with the carnivore diet, I found I could stay in ketosis with higher protein intake than the...

Oxygen poisoning is generally considered to not occur at atmospheric pressure. However, this is based upon the use of oxygen at rest. With the increase in ventilation while exercising, there would be a risk of oxygen poisoning even at atmospheric pressure. Bigtex hit on all the various risks...

A now deleted post evangelized the benefits of EWOT. I'd never heard of EWOT, so I did a little research. The scientific research underpinning it was performed by a German scientist - Dr. Manfred Von Ardenne. He published a book on it, which you can read the first section of here: Oxygen...

The problem with these population level studies is that they don't take into account inter-individual differences in their response to salt. Some people are hyper-sensistive to BP changes with salt intake. For others salt has little effect on their BP. A general recommendation to reduce salt...

For anyone that's interested in it, BIO101 is 97% purity 20-hydroxyecdysone, which is available as a supplement. Recommended dosing:

No. Completely different drugs. CC is clomiphene citrate - brand name Clomid.

It just depends on what's driving the pain. Some things can only be resolved by surgery. Unfortunately, surgeons generally will advise that surgery is the only thing that will work in cases where that is not true. So always take what a surgeon says with a large grain of salt. If you decide...

No. You don't have anything to bank right now. You'll probably need 12 months or more of HCG/CC to restore spermogenesis. Once spermogenesis is restored you should go on a maintenance protocol to maintain your fertility. Banking sperm is for someone who hasn't started TRT but is planning to.

There is another paper by Lipshultz et al that looked at the probability of recovering spermogenisis after TRT by age and years on treatment. Age and Duration of Testosterone Therapy Predict Time to Return of Sperm Count after hCG Therapy I wouldn't give up yet. You're still young and the...

Fascinating paper. The theory that humans can only utilize a limited amount of protein in one feeding never made any sense to me from an evolutionary perspective. Hunter/gathers will gorge following a successful hunt. This paper pretty conclusively shows that small frequent protein feedings...

Again this isn't best practice. The longer you have suppressed LH/FSH, the less likely you'll be able to restore spermogenesis. Preserving fertility in the hypogonadal patient: an update

Never had a problem TC, but when I was experimenting with daily HCG I had a stopper degrade to the point that I started getting bits of stopper in the vial. I think it has more to do with low quality rubber being used than anything else.

51.9 and 51.6 are effectively the same value as this within the measurement error of the test, not to mention day to day hydration variance that will affect the value. Importantly though, the trend is flat rather than increasing, so you may be stabilizing at this level, which as you note may...

The 1ml vials are overfilled to account for the waste. I find they usually have 1.1-1.2 ml. For low dose daily, the 1ml vials would be better. While sterility generally isn't going to be an issue on a 10ml, the stoppers can degrade with a large number of punctures depending on the quality...

Your math is off. 40mg every other day is 140 mg/week, which is a reasonable dose. Titrate to find the minimum dose that consistently resolves your symptoms. There is a lot of individual variability. Don't pay any attention to what someone else does. Do what works for you. Stay at dose for...

Yeah, the 10ml coupon prices are better than the 1ml prices, but I can't get anyone to fill 10ml other than the compounding pharmacies. Still way more than it used to be. It's about $60 for 10ml including syringes from a compounding pharmacy. More than that coupon, but at least I get a 10ml...

My insurance used to pay for T cyp. Then they decided to stop paying. In order to continue paying for T cyp my physician would need to appeal, write a letter, and submit multiple test results showing my testosterone is below 250. He said the review boards will rarely accept the hypogonadism...

Obviously you're not familiar with longevity research. The effect of diet on longevity is poorly understood. While there is likely an effect, what approach to diet will improve longevity is not known. The research on exercise is definitive. It improves lifespan in virtually every study that...

This is just a nonsense regulation promulgated by the government that does more harm (higher cost) than good. 10 ml vials being used for months/years was standard practice for decades without any problems. My guess is that pharma companies used the theoretical risk of contamination of some...