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  1. J

    Why All Men Should be Tested with the Sensitive Estradiol Test

    Don't have the time to reply fully, but you'd be one of a handful of men to have an aromatase deficiency, and usually it's very obvious. Not sure what the LEFs hard stance against the sensitive test is, they sell labs, they should give options for people to buy labs, not get unwanted opinions.
  2. J

    Why All Men Should be Tested with the Sensitive Estradiol Test

    I believe you're looking at this wrong, by asking if knowing how low your E2 actually is matters. As has been stated(by you as well), it may end up that a sensitive test reads higher than the standard, in which case that is critical information to have. I've often believed I could predict my...
  3. J

    I have been Primary Hypogonadotropic all my life, how will HCG help?

    hCG wouldn't be injected every two weeks, and neither should testosterone. That's a terrible protocol. hCG benefits vary from person to person, like any other drug, so you'll simply have to find out. What you've written so far regarding its benefits is mostly what I'd say they can be.
  4. J

    I have been Primary Hypogonadotropic all my life, how will HCG help?

    The testes will not respond to hCG very well, but the LH receptors all over the body will, primary hypogonadism typically effects the testes, meaning they are incapable of producing sufficient testosterone in response to LH or hCG. There are other benefits to hCG other than just preventing...
  5. J

    New guy with Defy labs. Waiting on consult

    On a proper protocol, like what Defy will likely prescribe, you'll very likely notice a huge change with your levels. Your test and E2 are very low.
  6. J

    Just got my labs back and I have a question.....

    Definitely get a thyroid panel done, as there's almost certainly something going on with that TSH level. Other than that you just look like you have low testosterone and I have faith Defy will help you out.
  7. J

    Just got my labs back and I have a question.....

    Just post all of the labs, you would have had input by now.
  8. J

    Initial Lab Results, well, kindof

    They used 2-4 weeks for injections. Not exactly the best protocol, so not sure if the results from that study are very useful.
  9. J

    High E2 symptoms with normal E2 test? Take adex or not?

    There is absolutely nothing wrong with that E2 level. Do not take adex.
  10. J

    Initial Lab Results, well, kindof

    I don't understand how you're not fully suppressed, that just is very weird.
  11. J

    Two and One-Half Years on Daily Injections: Stability Maintained

    You've been making some great points and realizations lately, doing some research I assume?
  12. J

    Defy 1st Protocol Followup Labs @ 3 Months?

    They do that to minimize expense for patients, but if you want to do it sooner, that's up to you. This way people aren't forced to spend more than is necessary. You get a choice in following up sooner, or saving money and following protocol.
  13. J

    Defy 1st Protocol Followup Labs @ 3 Months?

    I'm telling you from my experience with them you can order labs whenever you want.
  14. J

    Defy 1st Protocol Followup Labs @ 3 Months?

    Then order the labs and consult at 6 weeks, you can do consults earlier, or order labs whenever. Just gotta call.
  15. J

    Guidance with Initial Labs (very low Free-T)

    Honestly, these are pretty standard labs for low testosterone, nothing really sticks out except for low Test and low E2. They're boring, which is good. I'd say you've found your problem. Be happy with boring.
  16. J

    Question For Those Backfilling Syringes...

    So many guys try to do exactly that, invent a problem where one doesn't exist.
  17. J

    Question For Those Backfilling Syringes...

    Not sure why one would do this. 27g 1/2 inch insulin syringe takes 20 seconds to fill at most TRT doses.
  18. J

    At my wits end

    Lack of libido is your only complaint? Did TRT help your other symptoms?
  19. J

    T vs HCG, and how that effects Estrogen production

    You're probably correct, I do recall reading somewhere that elevated E2 and elevated prolactin are linked, but Testosterone is NOT converted to prolactin. Prolactin can cause gyno as well as E2. I was just making a technical distinction, not to be a know it all or anything, but just so that...
  20. J

    T vs HCG, and how that effects Estrogen production

    Testosterone does not convert to prolactin.
  21. J

    Labs look good but libido is still shot; help!

    Libido is often more complex than just hormones. You must consider psychological, stress, work, and even relationship factors.
  22. J

    Newbie protocol.

    Correct. The medication will be the right dose, but the price is the same for any dosage in that bracket.
  23. J

    Newbie protocol.

    I think it's just price bracketing. Think about the guys on .14mg adex. They would have to have 35 different options for the same price otherwise.
  24. J

    Can estrogen crash cause desensitization/knock out of the estrogen receptor - lets discuss!

    I mean, no one admits that it's psychosomatic, and personally I believe those that are adamant they're immune to the placebo effect or psychological causes of symptoms are even more susceptible to them. Keep in mind you're also not telling your doctors all the information you're telling us...
  25. J

    Defy/Empower Wait Time?

    I mean, UPS is experiencing issues as well as Empower due to the weather in that area, so really, it's unavoidable. Still not fun, even if it's no one's fault.
  26. J

    Can estrogen crash cause desensitization/knock out of the estrogen receptor - lets discuss!

    Yeah, no offense man, but that is terribly difficult to not categorize as hypochondria or psychosomatic, as people shouldn't be bothered by having normal body parts and the disappearance of problems. Now that I think of it, have you actually verified any of the quantifiable symptoms?
  27. J

    Can estrogen crash cause desensitization/knock out of the estrogen receptor - lets discuss!

    This symptoms are usually more prolactin related as opposed to E2. If anything, that's a good thing you're not having leakiness anymore. Keep in mind, and you may not want to hear this, sometimes you can be too aware of everything you body is doing. Some of it may just be confirmation bias or...
  28. J

    Can estrogen crash cause desensitization/knock out of the estrogen receptor - lets discuss!

    Yeah, see lack of nipple "puffiness" isn't really a symptom. Honestly I was more focused on your lack of hair, hair loss and nail issues because they are quantifiable. It's like when someone says they're "dizzy". It has no clinical meaning, and depending on their accent it can mean vertigo...
  29. J

    Can estrogen crash cause desensitization/knock out of the estrogen receptor - lets discuss!

    The only other thing I can think of is that somehow the low E2 triggered an autoimmune reaction and set off some latent disorder you're genetically susceptible to. A lot of conditions function that way, as in they have a genetic component that lies dormant with a trigger setting it off...
  30. J

    Can estrogen crash cause desensitization/knock out of the estrogen receptor - lets discuss!

    I found this: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637768/ That does seem to support your idea that crashing E2 can cause long lasting effects. Although the study refers to post menopausal women, which have significant differences than a 24 year old male so it may not be directly...
  31. J

    25 year old trying TRT - Defy protocol and Thyroid questions

    How do you feel? Also, why wasn't the Estradiol Sensitive test ran? I know Defy only orders that one, unless you had a written prescription, which it looks like you did seeing as the reference ranges look like Quest's.
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