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Table of Contents Clomid (generic name: clomiphene citrate) is a medication commonly prescribed to treat infertility in women. It stimulates hormone production in the female body, promoting ovulation (the growth and release of a mature, viable egg to be fertilized). It's one of the most...

Table of Contents Since the discovery of Metformin (way back in 1922), the medication has become one of the most vital medications in the world. The WHO has included it in its List of Essential Medicines among other drugs used to provide basic healthcare, and it is currently the most widely...

Let's try to clear up some confusion here. No need to debate what the E2 level in a young male going through puberty would be but yes it can run >70. This is not the point. The point is that a level of 70 is not harmful to men. The harm to men is with blocking estrogen. After 50 years of...

Table of Contents By Will Brink www.BrinkZone.com First, the important part: I’m not against testosterone replacement/hormone replacement (TRT/HRT) in the least, and was writing about the importance of testosterone before the internet existed and decades before the current “low T” trend...

Table of Contents Did you know that erectile dysfunction is a surprisingly common problem among older men? Roughly 5% of men over 40 suffer from ED, but that number jumps as high as 25% by the time you reach your mid-60s. While ED is fairly common, it's important to understand that it's NOT...

Women, in far greater numbers, deal with Irritable Bowel Syndrome (IBS). Several models have been proposed to examine the role of sex hormones in gastrointestinal function. Sex hormones may influence peripheral and central regulatory mechanisms of the brain-gut axis involved in the...

Exogenous testosterone decreases serum levels of high-density lipoprotein cholesterol (HDL-C) in men, but whether this reflects altered HDL function is uncertain. Healthy men (n=45, 19-55 years of age) were rendered medically castrate with the GnRH antagonist acyline for 4 weeks and...

In the United States, testosterone replacement therapy is approved by the FDA for treatment of classical hypogonadism. Off-label indications have resulted in a dramatic expansion in prescriptions in the American market. It is the belief of many that marketing - to potential patient and doctor...

While there have been studies of the role TRT may play in terms of cardiovascular disease, there have been few focusing specifically on TRT and stroke. Testosterone Replacement Therapy and the Risk of Stroke in Men: A Systematic Review, "Maturitas, The European Menopause Journal." December 2017...

It's been known that androgens play somerole in the development of kidney stones. Women are three times less likely than men to suffer with a kidney stone attack. Kidney stones occur in men with far greater frequency in the third and fourth decade of life when the levels of serum testosterone...

At the present time there are only two approved methods for treating androgenetic alopecia: finasteride (indicated for men only) and minoxidil (indicated for both men and women). A recent study examined the possibility that a caffeine-based 0.2% topical liquid might work as well as minoxidil 5%...

Adults with prediabetes assigned to zinc supplementation are less likely to progress to type 2 diabetes compared with adults not assigned to supplementation, and supplementation may lead to reductions in fasting plasma glucose, 2-hour oral glucose tolerance test and insulin resistance, according...

In primary hyperparathyroidism, an enlargement of one or more of the parathyroid glands causes overproduction of the hormone, resulting in high levels of calcium in the blood (hypercalcemia), which can cause a variety of health problems. Surgery is the most common treatment for primary...

Autologous platelet rich plasma (PRP) is used increasingly in a variety of settings. PRP injections have been used for decades to improve angiogenesis and wound healing. They have also been offered commercially in urology with little to no data on safety or efficacy. This small study holds out...

The Testosterone Trials are set of multi-institutional, double blind, placebo-controlled studies aimed primarily at determining the efficacy of testosterone replacement therapy (TRT) on sexual function, physical function, and vitality. Seven hundred and ninety men over the age of 65 yr with...

Adolescents who created real-world diets attempting to avoid exposure to bisphenol A, or BPA, for 7 days experienced no change in urinary BPA levels and reported difficulty in avoiding the endocrine-disrupting chemical, according to findings published in BMJ Open. “Based on our evidence...

Urologists see it all the time. Pain in or near the scrotum, perineum, or penis, frequently made worse by urination or ejaculation. A diagnosis of prostatitis is made and antibiotics start. Followed by more antibiotics. Prostatitis has been subdivided, bacterial/non-bacterial/chronic/acute...

Women present with inflammatory bowel disease (IBD) far more frequently than men. As such, a considerable literature on sexual issues in women with inflammatory bowel disease (IBD), but relatively little attention has been paid to these aspects in men. A review of the available literature...

About two years ago, when I was 37, I had a physical and asked for a testosterone test mainly because I knew my dad had problems when he was about my age (he died in 1994). It was 108 ng/dL (range 300-1000). I guess that should have set off alarm bells, but the doctor wasn't worried and just...

Table of Contents There's no doubt about it: porn has caused desensitization of the modern generations. What was once taboo (nudity and sex) is now so commonplace as to be almost considered "normal". People of all ages can get their hands on an incredibly wide variety of pornographic...

Table of Contents Another possible positive benefit for e2? Highlights The effect of estrogens on tendons and ligaments is poorly understood. Research implies a positive effect of estrogens on tendon tissue biology and biomechanics. However, results are in part conflicting...

Cardiovascular disease (CVD) is currently the most important cause of death in developed countries. Atherosclerosis, the underlying cause of most CVDs, is a dynamic and progressive inflammatory disease characterized by lipid plaque formation within the arterial wall and luminal reduction...

Table of Contents Hey there everyone. I've been debating posting on here for some time, only silently reading, but I decided that my story may not only help someone else in the future who is in a similar situation, but it may also help to show a different side of story, particularly since...

Table of Contents Some men believe that TRT will relieve anxiety, but this study says otherwise. Men were stressed by challenging their status. Those who had applied testosterone gel showed increased cortisol levels. The effect was larger in men who tested higher for dominance. The abstract...

Higher concentrations of arsenic and fluoride in the public drinking water supply in Newfoundland and Labrador may be associated with the high incidence of type 1 diabetes in the Canadian province, according to findings published in BMJ Open Diabetes Research & Care. Newfoundland and...

Table of Contents Background The effects of vitamin D on sexual function are very unclear. Therefore, we aimed at evaluating the possible association between vitamin D and sexual function and at assessing the influence of vitamin D administration on sexual function. Methods We...

So after 6 months of adding FSH to my TRT protocol I got a sperm analysis done. A quick background. My fertility was normal before TRT and went to zero when I started TRT without HCG. Adding HCG 500 IU 2x a week my sperm analysis results were: sperm count 2.1mm (normal >=20mm) total...

The study was a 2 x 2 factorial design where older men were given 100 mg of testosterone a week or not and were eating 1.3 g/kg or 0.8 g/kg (the RDA) of protein a day. No mention is made in the summary of any exercise program, but the summary says the men were "functionally limited." The men...

Table of Contents Alright My Friennd Here's Some Knowledge That Will Change Lives On TRT Forever Originally wrote this as a reply to someone on a different thread, but decided to put it in it's own thread as well. say you take 1mg of Arimidex EOD. The half-life of Arimidex is 2 days. So in...

Table of Contents Testosterone replacement therapy (TRT) is one of the most effective methods for treating hypogonadism, erectile dysfunction, and sexual dysfunction. Sadly, as with any treatment, a minority of men may experience hair loss. A small but concerning percentage...

Synthetic cannabinoids are designer drugs that differ in some significant ways from the natural cannabinoids found in cannabis plants. They are often marketed as designer drugs or sold in products with claims they give the same effect as cannabis. Synthetic cannabinoids (SCs) have been...