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Long-term TRT patient, current protocol is 154mg/week in EOD SubQ shots (into thigh, belly, hip, etc). I've struggled on and off with digestion issues (constipation) and lack of deep sleep. A few months ago I started intermittent fasting and it's been good for dropping some weight. That combined...

I’m a long term TRT patient, 39 years old. I’ve been on cypionate and inject a total of 154mg weekly in EOD subQ shots of 44mg each. I have been doing some thinking about the potential benefit of keeping dosing the same but experimenting with using a low cypionate base around 80-100mg weekly...

I'm interested in trying tadalafil for vascular health. ED not an issue but like what I've seen about tadalafil for health overall. I'd prefer an ODT (orally dissolving tablet) that I can dose as low as 2.5mg at a time. Has anyone seen tadalafil orally dissolving tabs from an online pharmacy? I...

What times during the day should I take the saliva samples? I have a kit from Labcorp but theirs is keyed for taking one sample a day, while I want to do 4 samples in one day. I'm not sure when during the day to take each sample.

My primary care doc RXd some labs for me so my insurance would cover them. I will be sharing the results with Defy but am not sure I'm going to continue working with Defy (long story). One of them is the LabCorp 4-tube saliva cortisol test. I have the test kit, but it specifies doing it over...

As part of an unsuccessful recent experiment with my protocol (nandrolone added to testosterone), my sleep apnea appears to have gotten noticeably worse over a very short period of time. I haven't been treating my OSA since it's typically so mild if I sleep on my side. I'm wondering if anyone...

Basic Info I'm 6 days into a major protocol change overseen by Defy Medical and feeling really strange and unsettling side effects. There are some confounding factors that are making it hard for me to know what to do. Defy is closed for a few days for the holiday so I can't get a consult and...

I am in the middle of a trial of transitioning from TRT using cypionate to propionate. The goal was to try to beat some water retention I'd been struggling with for years. I'm working with Ben Walker at Defy Medical. I have a consult with him tomorrow but just got some labs in and I would like...

Can anyone comment on whether there are connections between IGF-1 levels and use of exemestane/Aromasin? I’ve seen conflicting reports on the way that different AIs affect IGF-1, and I’m especially curious if anyone can share both anecdotal and research-based info on how Aromasin may affect...

Background I'm 36. On TRT for six years. 6'2", 215lbs. Have had my GP manage my TRT and have never gotten specialist care to get dialed in. I'm in the process of signing up with Defy Medical to have Dr. Saya manage my TRT. My GP has had me on 50,000 IU per week of Vitamin D2 after I came back...

Hi all. Looking forward to being a member here. I'm 36 and have been on TRT for 6 years. I've never had anyone other than my primary care physician administer T to me. I'm finally getting started with Defy Medical (just had bloodwork this past week) and am looking forward to working with a...