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Based on my own research, epigenetics would be the only logical and plausible explanation. I am not sure through what mechanism increasing endogenous E2 makes my symptoms worse but if I had to speculate it's through epigenetic alteration i.e. methylation of a gene, which would further silence my...

Madman, thanks for your thoughtful reply. I have never used a DHT inhibitor. Estradiol in men is responsible for all of those characteristics as well. There is a lot of cross talk between steroid receptors and share a lot of gene activation. I will post a great study in about 30 minutes...

This is true. But notice the phrase, key player. So it's not the only player. Which is why I still grow a thick beard. But Estrogen Receptors are found in hair follicle cells which mediate growth as well. Just speaking about my beard as an example, my beard grows a bit more slowly,, it's very...

Doc's won't prescribe the rT3, they don't see it of any clinical value. And based on my other labs for thyroid, it looks fine. I also do not have sleep, energy or fatigue issues. I appreciate the suggestion and interest in my case but I don't think it's vascular in origin, but certainly causing...

I only have one reading, which is for the 750 TT level. Which was 31.8 (16.5-55.9). Don't think it jumps around to much as my TT is always high and FT doesn't really mimick my TT.

SHGB is 31 (15-55) I agree. My low E2 symptoms that I typically get so not resemble any of the symptoms I've stated. My low E2 symptons are good pumps, morning erections, no water retention, nipples aren't puffy, great libido, and dry mouth. And Ive stated, the exact same protcool I am on now...

Yes I have. I had one in the summer, which is the one below. Protocol was 120mg T/week and 0.5mg Arimidex per week. T level 1250, E2 17 (8-35). Was having symptoms here. Next, Endo said drop Arimidex. T level 1225, E2 36 (7-42.6) Symptoms got even worse. Next, Endo said lower T dose to 100mg...

Thought I would contribute some pertinent and useful information to this thread. I did two months of 30mg T Cyp EOD subcutaneously, no AI no HCG, put me at 750 ng/dl 24 hours after my shot. Did the same protocol intramuscularly, and pulled a 1006 ng/Dl 24 hours after my shot.

Update: All physical and sexual symptoms continue to get worse. Still on 100 milligrams of Testosterone Cypionate a week. Currently have 0 stress, almost no anxiety, still crushing school, but depressed about my situation. Sleep is still excellent and so is my energy. Have been seeing a...

1/16/15 TSH 1.570 uIU/mL 0.450 - 4.500 Thyroxine (T4) 6.3 ug/dL 4.5 - 12.0 My Problem started on 5/23/17-5/28 area 10/24/17 TSH 1.440 uIU/mL 0.450 - 4.500 Thyroxine (T4) Free, Direct, S T4,Free(Direct) 1.26 ng/dL 0.82 - 1.77 Thyroid Antibodies Thyroid Peroxidase (TPO) Ab 9 IU/mL 0 - 34...

I agree. But that has been ruled out by a ton of blood work (posted numerous times here) 2 endocrinologists, and my TRT doc. Was even prescribed 125mcg T4/day and it did absolutely nothing for my symptoms and made me dizzy. Also do not have any fatigue, have regular bowel movements, and I'm...

I don't know either. My buddy's joints do not pop when his estrogen is very low but they're definitely more achy. Same with me, my joints pop high or low. But when it's low they are painful.

Thank you I appreciate it!

Soon to be nurse. Joint cracking isnt debilitating but it's annoying.

Pretty good in the morning. How do you feel?

Currently they do. But nothing like they used to feel like when I was normal.

Great observation man. When I used to go too low on estrogen, my joints would absolutely kill. I couldn't do skull crushers or anything that put a lot of stress on my elbow joints. This is probably because I used to get very dry and urinated a lot. In late May and in June when I practically had...

I'd also like to add that I'm still pretty strong, but my strength will not budge and stays stagnant as long as I'm going to the gym. I also do not get even the slightest bit of blood flow or pump and get absolutely no "burn" in any type of workout. When I was normal, my strength would increase...

I feel like being on Nebido is like being in the dark. At least with T Cyp you know the half life is 8 days on average.

Yes, I used to have the most incredible memory, almost photographic memory which came in handy during my anatomy and physiology practicals. I could recall anything in short term or long term memory. Now my short term memory is going quick and can't remember names of things, things that happened...

New bloodwork. 29mg T Cyp EOD IM. No arimidex obviously. Hemoglobin 16.8 (13-17.7) Hematocrit 47.4 (37.5-51) Platelets 143 (150-379) LOW CMP and Liver enzymes in normal range Urinalysis normal Total T 1006 (264-916) Free T 24.2 (9.3-26.5) A1c 4.9 (4.8-5.6) DHEA-s 374.3 (164.3-530.5) Cortisol...

Believe me I've read it, I've even talked to CD at swolesource. CD had none of the severe symptoms such as bone loss, shrinkage, and he reacted positively to any kind of androgen increase. He had hypogonadotropic hypogonadism, as do many other men. This can certainly cause gut issues and thyroid...

What do you mean fix our guts? What is making you think my gut isn't optimal?

I can offer you at theory, but it'd be pure speculation. Even if I was right on the mechanism, you would not find any literature on it. This is the problem at hand. Theoretically, arimidex should absolutely not cause any persistent issues; its a reversible inhibitor of aromatase. I do not think...

Not doubting it is a powerful thing. I've admitted here I was giving myself psychosomatic pain in my back during my early years of lifting in high school. This is not that. There's been serious physical changes that are visible for everyone to see.

Its the opposite for me. My tolerance dropped heavily, I used to drink a pot of coffee a day, stove cooked so it was extremely strong. Now I can barely drink a cup. But what I was referring too was it mood enhancing effects I used to get. It ended in late May after I crashed my estrogen. I don't...

When I drink now it only feels a little different. I don't really get the intense euphoria anymore but it's still pleasurable. However, I do not get the same effects from caffeine and adderall.

Its really patient specific. For example, at 120mg (60mg x2 per week), I was getting peaks of 1325 TT. This is supraphysiological. I did not look natural by any means when I was on this dose. Nor did I look natural at 80mg (40mg x2 per week). It really depends on your metabolism and SHBG, your...

Everyone of those symptoms you mentioned, I have now. In the summer, when I felt I had much better estrogen sensitivity, it wasn't as bad and could feel connected to my loved ones. And I still had a sense of well being and decent libido. That's all gone now as I've made my situation much...

That is correct. Ran a T only "cycle" (not promoting this) for 20 weeks. Came off with Nolvadex and Clomid, saw a dramatic increase in testicular size and ejaculatory volume, felt great by 7-8 weeks off. Went back on again at 120mg per week, stayed on since. Felt incredible, until I crashed my...

Think about this scenario. 20 years old, no health issues prior, jumps on TRT. While on TRT, still no health issues. Great libido, great hair, great erections, great skin, no muscle wastage, recovery is great, mood is incredible, doesn't know what depression or anxiety even is. Used nolvadex and...