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Perhaps we shouldn’t be using “normal” ranges on Nandrolone based HRT is what I’m saying. Since those ranges were established from natural men with normal biochemistry (T,DHT,E2). I would pay attention to lipids, kidney, liver, CRP, BP, prolactin, inflammation, insulin sensitivity, skin, hair...

Actually, a better model than MtF transgenders for E2 being necessary for all things libido and erection in men, would be androgen deprivation therapy patients. Neal Rouzier has mentioned it in TOT videos. Estradiol restores their sexual function in the absence of test. And nandrolone/DHN are...

Y’all keep in mind nandrolone binds to AR ER and PR. So tweaking around E2 is key. I think DHN vs DHT is massively overblown with regards to erections. Why is that? You can get “Tren dick” when running it by itself and Tren is MEGA androgenic, more than DHT. Very manly. However there is no...

I don’t know about the frequency of Deca dick in general. I’ve mostly seen AI abusers report such a thing, so my take is whoever has too high or too low of an androgen/estrogen ratio is going to have ED symptoms. Prolactin is a pretty good surrogate for this ratio. Nandrolone only tends to...

That’s a lot of words for “lack of estradiol”

Me mentioning biphasic kinetics is mostly because @Gman86 mentioned testing TT at a trough. From what’s seen below (Fig.2), response to E3.5D HCG injections seems fairly predictable and TT levels should be stable throughout till the next injection is given HCG 0-6000iu study

Since HCG has biphasic kinetics it’s not shocking to me that 350iu injections yielded T in the 400s. At least from my experience with 500iu’s twice weekly leading to T in the 600s. Especially with Deca lowering SHBG, which increases Testosterone clearance. If anything infrequent injections may...

Absolutely. I never take studies as face value, rather as starting points from which one could decrease or increase their dosage based on bloodwork. At least that’s how I operate.

You never tested E2 / DHT?

Well this is isn’t what I’ve seen from my own N=1 doing HCG mono for a while. Fairly stable T&E2 output over a few months. Regardless, I’d start with 250 eod not 180.

fantastic experiment you’re doing. FYI I think that based on the following study that I’m sure has been posted and discussed many times already here, you may want to just go for 250iu eod of HCG. I’m gonna go ahead and guess that this will yield optimal levels of E2, based on the fact that it’s...

I do have the same belief regarding an anti estrogenic effect from DHT. I thank you for all the solid data you’ve been sharing consistently throughout this thread. As I’ve been having very dry joints, skin, hair forever and low estradiol many times naturally I believe that I need to rebalance...

Testing DHT is probably out of curiosity since I’m using HCG. Everyone knows HCG induces intracellular aromatase but it also induces 5ar, so I’m curious. I wouldn’t want to defeat the anti androgenic purpose of this Nandrolone based HRT, pinning too much HCG. I’ve run HCG solo for a while doing...

My only issue is that I'm not in a state where I can freely get Total and Free Test assayed proper, plus I'm about to move across the border to Ontario anyway. Should I disregard evaluating Testosterone altogether? Realistically all I'd get via ROCHE testing would be serum total Nandrolone...

will do! in the meantime I'd like to add this excellent review and bloodwork with surprisingly thorough analysis by Derek here NPP 80-100 mg/wk transdermal estradiol gel 1.5 mg/day