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This might get more views if moved to the appropriate sub forum... Though I haven't experienced it (never used Trimix) or heard first hand about it, I would think what you are experiencing would be somewhat common in guys using Trimix for ED. Here is why: Guys that are using Trimix often have...

I'm currently using cream again - 100mg AM, 50mg PM. This is a good protocol for me and has been one of my "go to" protocols, the other "go to" being 60mg T Cyp E3.5D (120mg/wk). Seems like whenever I try to a new protocol that doesn't work out, I go back to one of these to get back on track...

I have, though I can't say with good results. I wouldn't say it was a disaster, it just wasn't worth the hassle as I didn't notice any real changes. I have heard of guys adding a small amount of cream to an injection protocol to boost DHT, which makes sense. As to when you notice the benefits...

@DS3

What effects, if any, does TRT have on neurotransmitters, particularly on serotonin? I know that in the initial stages of TRT, there is a pronounced effect on dopamine - I have been told that this is what causes the "honeymoon" that many guys experience. Are there neurotransmitter imbalances...

Yes I do. However, libido was never an issue for me even before TRT. If anything though, TRT and cream in particular increases it.

Unfortunately no - my doc at that time didn't test DHT (new doc now).

I have - reported on this a while back. Here is the thread: 2x day cream - surprising stability

I have used cream exclusively on my wrists/inner forearms. 100mg in the morning would have my levels in the mid 800s at peak, so it definitely works.

FWIW, my most recent cream from Empower is also more oily/runny than what I had received from them in the past. I don't like it as much, mainly because due to the consistency it seems like my clicks aren't always accurate. Especially the first click. Never had any issues with their cream before.

When I first discovered this forum about 2.5 years ago when I started TRT, I remember reading things like this. Did I listen? No. Many of us have to learn the hard way. After 2.5 years of ups and downs and spinning my wheels, just now coming around to the realization that what Tman stated is...

You might consider completely dropping the HCG. It never seemed to do much for me, other than drive up E2. And lowering T dose will also drop E2 of course. So many guys come on here and say how much better they feel on lower doses, and that they wish they had done it sooner. But for many of...

Please do update this thread to let us know how things went for you.

How old are you and how long were you on TRT?