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Does that mean you're intellectually honest enough person to admit you were wrong? Or, will you only use him as a reference here as it pertains to methyl donors but not as it applies to your prior claims which he outlined were incorrect?

Then you may need to listen to that show again. I commented on it in another thread, and no place does he recommend not using NR because it consumers methyl groups per se, but he does recommend some nutrients to take as methyl doners, and recommends what I have for decades: taking creatine to...

Great show, A good discussion on NAD, NAD precursors, etc. Note at 1:27 in the show discussion of papers finding NR was superior to niacinamide for NAD levels in muscle tissue and all important mention of tissue specific kinetic flux. At 1:28, discussion of the rational as to why taking NR is...

My instincts say yes, the data however does not exist at this time. Per article and posts in this thread, will depend on factors such as age, health etc. I'd expect someone who is active and practices CR would benefit less, but we can say that for a lot of things. I'd also expect if they match...

Tissue levels are what matter, and testing tissue levels difficult to impossible depending on the tissue. It's well established that tissue levels decline predictably with age and various disease, etc, and that low levels are associated with all manner of age related stuff best avoided. The real...

Owned by a friend of mine who also owns Life Extension. He's all about furthering the science of anti aging and we are now making real progress in that area. That's something I may add in as data continues to come in. I'm much more comfortable with NAD and NAD precusors from a data and...

Maybe I'm missing the connection, but NAD+ and Rapamycin are sorta apples and oranges thing. What's your dose/schedule on the Rapamycin? Schedule most do is 3-5mg 1X per week. That's also a very interesting and promising area. You may find this site useful on Rapamycin and other anti aging...

Will read. That studies suggest benefit regardless of controlling elevated hematocrit no? I don't have elevated HM myself, but was interested by that data enough to consider blood donation on some sort of semi schedule.

And that may be one approach to increasing NAD+ levels, but adding quercetin and apigenin comes with far more potential negatives than adding NR to an invivo system. I'm not against the concept, but if one is concerned with a hammer approach to a large number of enzymes, adding quercetin and...

False. There's nothing miseasding in that article nor anything posted here. False, and paper supplied showing such. You're looking less and less informed on this topic with each post now. Again, false, and data supplied. It's interesting to note (which you'd understand if you read/understood...

I have addressed that repeatedly, so either you're not as well informed as you think you are and or lack the sci/med background for the discussion, or you're intentionally being obtuse. Either way, you're now wasting my time at this point. So yes, we will wait until there's further data to...

As I keep repeating, that appears to change with age, so it probably applies well to a 25 year old, but not to a 63 year old person, and so forth. We have something like 5% of the NAD+ levels we had by 80 years old. There's more going on there than your overly simple conclusion that NR/NAM are...

What does that actually mean? What tests have you done? I can say I feel my energy levels and mood have been elevated since I got that NAD+ infusion, but I'm also fully aware that may be placebo and expectation bias on my end, and until there's solid data, my n=1 subjective experience does not...

I addressed that above and have read that study. I linked to a human study that found NR raised NAD+ levels in humans, and in addition to animal studies, we know not all orally ingested NR is converted the nicotinamide in the liver. That may also be why, per my article, infusions for those...

At a total of 400mg per week, I'd expect one to feel great, be stronger, etc. Add another 200mg, and you'll feel even more amazing. The issue is there's a deminishing return between those short term benfits and effects, vs the long term risks. 10 weeks of Deca added to your TRT (and 200mg per...

Great info. My Q is, how often on average did the study find benefits?

It's not a form of Niacin per se, but a downstream metabolite and if it consumed methyl groups to any great extent, the animal data, etc would not be so promising nor would low NAD+ levels be so strongly associated with so much negative age related stuff. No, that one is overly simplified. In...

Did you read the article? While more data needed, this one may be legit. I would not be so quick to dismiss NR as a supplement for raising NAD+ levels. Now, whether raising NAD+ levels = the magic elixer to aging is another matter, but what exists for data is compelling.

Source? Niacinamide converts to NAD+/NADH, not the other way around, but may also increase Niacinamide in some tissue via tissue flux so the process is not one way apparantly. NAD+/NADH. NAD+ levels drop as we age substantially suggesting conversion of Niacinamide to NAD+ is reduced with age...

I'd say read article and decide for yourself. Jury is still out for me, but I did get an NAD infusion and it clearly holds promise. How much, for who, etc is unclear until some human trials get published.

Dat ^^^ :cool:

Confused over all the hype over NAD? I get down to the facts vs hype over this molecule and even had an NAD infusion done myself! Nicotinamide adenine dinucleotide (NAD) is an essential cofactor found in all living cells, essential for energy production. To get a tad more technical, it’s found...

Statically speaking, getting the weight off is not the hard part, keeping it off is. Will they be following keto/VLCD forever? There's something between keto and high carb diets, it's called a balanced diet. Not to be snarky, but I most people viewing this topic in an overly extreme/black white...

I read an awful lot of studies on nutrition, supplements, and so forth per my job, most not really worth noting here on BZ. Not that they are bad studies per se, but they don’t really tend to tell us anything we don’t already know or add much to the body of knowledge. Once in a while a study...

Cysteine and more importantly, Glu-cys moities (bypasses rate limiting step in GSH production) only found in whey, and very small amount in egg yolks. Whey is a unique protein on various fronts.

The article you posted does a good job of showing it's not likely to apply to active healthy people, and other studies suggest benefits to glucose and insulin metabolism: The Whey to Weight Loss! | BrinkZone.com

See also: Whey Q&A

No, people should start, just like any hormone, because their blood levels are not in the healthy range. Full stop. Not sure why this hormone (really a pro hormone), is viewed any differently because it's OTC. There's no benefits keeping DHEA-s above the physiological ranges, and in some, may...

Protocol is, Like T, it's based on blood levels. DHEA does tend to drop after 40 ish like many hormones, but like other hormones, blood work is what decides to add it or not. Replacement for men is typically 25mg, but varies, just like other hormones. Randomly adding DHEA makes no sense at all.

I have not really gotten down to granular levels as what treatments vs others, but LEF tends to keep on top of the topic, looking at both traditional and non approaches, and a good place to start researching the topic: Prostate Cancer Treatment | Life Extension

So, we come full circle to T potentially being used to treat some forms of prostate cancers: "Rationale for Using Supraphysiologic Testosterone to Treat Castration-Resistant Prostate Cancer.” We have known for decades that androgen deprivation offers remarkable efficacy and palliation for men...