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Even more effective than Semaglutide, a GIP/GLP-1 combo, the latest! How were you able to get a scrip? How long on it? Besides you "feeling" less glucose, has it actually reduced fasting glucose levels? Weight/fat loss? How's the nausea? Constipation from delayed emptying?

I'm in the same boat always having had high FBG. Even if I eat a protein snack at night, it just raises my glucose levels the next morning. It just hangs. Was hoping Met would suppress that. Only thing that suppresses it is moderate exercise like taking a walk or fasting for 15+ hours and...

I assume you're non-diabetic? How long have you been on it? Strange our glucose readings don't change. I still don't understand exactly the mechanism but I think it has something to do with glucose homeostasis in that diabetics have impaired beta cell function whereas non-diabetics do not -...

I've been on Metformin for a month now. I am not diabetic and am taking it for the anti-aging and cardiovascular benefits, etc. I eat the same diet (low carb). I have not seen any difference in my fasting or postprandial readings. Same issue with taking berberine (which I still take with...

The new GLP-1 + GIP all-in-one, Mounjaro. More here.

Interesting mechanism. In my case, despite my low carb diet (<100g), I think my insulin sensitivity has gradually degraded with age as is normal. I take glucose disposal agents like cinammon, banaba leaf, berberine, etc. but have not noticed much difference. I'm looking into metformin and...

That seems to be a paradoxical to what one would think: that fasting would keep the fasting glucose levels lower and a bedtime snack would make them higher. Can't figure that one out. I am just the opposite. If I snack, my readings will always be higher, especially with any form of carbs or even...

Down 12 lbs now. Starting to see the bicep vein gives me hope that fat loss is possible. I still credit this with the slight increase in my desiccated thyroid dose (I believe I was under-dosed). May need to bump the dose a little more so TSH is @ <2.00 (it's around 2.5 now). That and more days...

Update: I have lost approximately 10 pounds since starting this thread. Some of that of course has been fat as well. Strength has gone down maybe a tiny bit. Calorie restriction is difficult but a necessity at this point. The only other thing that I still need to work on is hormone optimization...

why only 3x's/week?

2 pharmacies in that example. Shipping costs should not be marked up, but whatever.

$52 shipping for an order of $135 + $45 for hair products

Has anyone been able to find an alternative supplier that doesn't overcharge for shipping? I realize they are not the actual pharmacy, but charging as much or more than the cost of the item itself is insane. That is on top of an already marked up full retail price item.

I don't care how many credentials a cardiologist may have behind their name. If they are completely pro-pharmaceutical and don't consider the whole picture and outside factors such as hypothyroidism, insulin resistance, diet, lifestyle, and are against non-drug remedies like fish oil, niacin...

Along with all the other drawbacks, statins could actually increase Lp(a). From what you've stated + your labs, I don't see any reason why you would need to be on any lipid management, especially when you're fortunate enough to have thyroid & glucose levels optimized without any intervention...

What were your numbers before the ezetimibe? How long on it before these labs? Did it have any effect on your trigs, LDL-P and small LDL? Or no effect? How are you able to get a prescription for a PCSK9 inhibitor when it is specifically prescribed for FH? My HDL is low as well. My total and LDL...

Perhaps your doc is basing his opinion on this study which I hadn't seen before: Niacin Increases Atherogenic Proteins in High-Density Lipoprotein of Statin-Treated Subjects

Just curious, so what are you using now to help reduce your Lp(a) and for general lipid management and has it been effective?

I don't know what specifically your cardiologist is basing that advice on. I had seen this older article before. It isn't even a case of 'correlation doesn't = causation'. All it really says is that niacin is supposedly ineffective in preventing mortality and says nothing about it causing any...

Anyone notice impact on fasting and post-prandial glucose levels and a1c from taking high-dose ER niacin to manage lipids? I was on 1.5g per day and increased to 2g per day and now I'm noticing glucose levels about 10 points higher. Wondering if this will subside over time. I know some are...

I am told that Semaglutide should be combined with methylB12 to help mitigate the nausea associated with taking it alone. Some compounding pharmacies are doing just that.

Kills 2 birds with one stone: stubborn bodyfat + insulin resistance.

I don't see what your problem is. In fact I'd like to have your problem. Putting on muscle and losing fat? That is the best that could happen as muscle is metabolically active in a positive way unlike fat which just causes more inflammation. What I need to do is recomp. If I gained weight but it...

When I first started treating my hypothyroidism, it was over 10 years ago and I started with T3 monotherapy. It had little to no effect and did not make me feel better. Since then, I've tried every mono and combination therapy under the sun. I think I will just continue my journey titrating the...

Latest TSH: 2.39 (see my full labs here). Goal: TSH between 0.5-1.0.

I'm not taking any supplementary iodine, so I don't know how that could be an issue or what that has to do with rT3 or FT4. I would think those go up because I increased my dose and did my lab draw only a few hours following my NDT dose. The goal right now is to suppress TSH to an optimal level.

Updated thyroid function tests here. With the .25 grain increase in NDT from the last labs, we can see noticeable improvement in TSH. I kept it consistent and tested it the same way I did the last time: 3 hours after my dose to see how the medication is working. I know that's not the way to...

20/4 IF is the most I have gone and probably feel comfortable with. After about 30 hours, I would be concerned about catabolizing lean mass, a no-no. At least that's what the studies have shown. Cycling carbs/kcals is something I need to explore, but need a strict template to follow. Winging it...

Although I am a member of Dr. Davis's Undoctored Inner Circle group, I feel the need for more extensive intervention from a live coach/practitioner. ER-niacin + other lipid-lowering supps do definitely work and perhaps the LC diet, but it's the APOB, pattern B and small LDL that continue to be...

Yes, am taking all of the above, thanks.