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Hmm. Never heard of this. Do you have any clinical papers that you can post?

IGF-1 has been coorelated to increased cancer risk but causation has not been proven. So we dont know if IGF can cause a cancer or if cancer increases IGF. Actually, there is some evidence that somes cancers can increase IGF, but that still doesnt mean that IGF cannot be a causitive factor...

1- increase injecting frequency - may help lessen increase in HCT 2- consider sub Q injections- may help lessen increase in HCT 3- get genetic testing for coagulation - so you know what you are dealing with. Meaning that if you have no issues you may be able to let HCT go a little higher 4- get...

But i guess that would be a matter of modulating the dose

Generally, no. But the length of the needle needs to be able to get into the muscle - assuming you are doing IM. So, you need to look at the thickness of the fat layer over the muscle you are injecting

Testosterone is known to enhance sleep quality

First off, symptoms are things that the patient feels. So, right from the start this is subjective. There is the placebo effect and the nocebo effect. Placebo effects are things that the patient feels that are not from the compound ingested - its from the mind. Nocebo effects are things that...

Important lessons about testosterone therapy- weight loss vs. testosterone therapy for symptom resolution, classical vs. functional hypogonadism, and short-term vs. lifelong testosterone therapy In this commentary, we highlight important findings from a notable RCT by Ng Tang Fui et al. 2016...

Inhibitors of 5alpha-steroid reductase are drugs used to treat androgen-dependent conditions including prosta...te diseases and androgenic alopecia. Finasteride was the first on the market and is currently the most widely used inhibitor. Dutasteride was the second inhibitor to be approved and...

very good

Well it can’t really be better than biopsy. If it’s select MDx is positive and the biopsy misses it, no one will treat you. The point of these tests is to assure you that you don’t have an aggressive cancer and spare you from an unnecessary biopsy. If you are looking for a test that will...

That’s an impossible question to answer. PSA Has been around for 30 years and people are still arguing over that However, what I like about select MDx is that it is an entirely different test altogether Did I you know that the 4K score incorporates 3 derivatives of PSA and another related...

The nice thing about this test is its negative predictive value is 90%

This is a great test. However, you most be off of finasteride or dutasteride for 6 months for accurate results

Multiparametric MRI are tricky to read. Get one in a high volume facility. Also, at this point in time the ability of the radiologists reading them is highly variable. I spoke to Dan Margolis just this morning about this ironically. He probably has read more than anyone in the country...

No way is it first line testing. And it is falling out of favor. see my response below

Careful with PCA-3. Memorial Sloan Kettering, Lenox Hill, Cornell, and Mt Sinai here in NYC have all stop using it do to a high flase positive rate. It for the most part has been replaced by 4K

Thanks Nelson!!

Gentlemen, I thought that this was interesting Currently, there is no consensus regarding the expected concentration levels of intra-prostatic sex steroids in patients with Prostate Cancer (PCa). Our objective was to assess the concentration levels of sex steroids in prostatic tissue and...

I thought it would increase HCT

I haven't read the whole thread. But I am not surprised that fatty liver is correlated with low SHBG because high insulin decrease SHBG

What do you mean by progressive?

I would not say it does not work for low SHBG guys. I would say, it is more difficult to get very good results. As Vince noted, frequent injections are the way to go. I would try daily IM and daily SC. See which is better

Great work out,. The reps are something similar to what I have seen VIctor Black recommend. Couple for questions: 1 - how close to failure are you getting on these sets? 2 - How much rest between sets. For example, if I do a 20 rep set to true failure, a one minute rest will get me to only 10...

How do you know it is the E2 that is causing the problem?

why replace it?

What if you had a 10mL vial and you do daily subQ injections. The rubber top may be punctured 100 times by the time that you are done - albeit with a very thin needle. Is the repetitive puncturing an issue?

Is the book merely what is on his website?

Dr. McClain I realize that finasteride and dutasteride both block conversion of progesterone to 5-DHP, 5-isoprogesterone and 5-alloprogesterone, which are important neurohoromones. Can this effect of finasteride and dutasteride be offset or partially offset by taking pregnolone or progesterone...

Doctor Saya discusses HCT and Fish Oil in this video however he never says that FO will keep HCT down. He is suggesting FO as a may to mitigate the negative effects of elevated HCT

Thanks Maximus - How did you present the fact that it wasn't effective since BlueSky has to pretend like they don't know that you are consuming it (I am not trying to be facetious). Did you just say that you noticed that it was not effective and kept it at that?