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Personally I noticed no difference whatsoever. Numbers "on paper" looked great, but with any injection schedule, it feels like I am injecting water in terms of symptom relief.

I have tried them in the past but not for the last year or so. I could never tell any difference being on them for a couple of months and when I ran out and was off them for a few weeks. I guess I could try them again and see what happens. They are not terribly expensive

I have and I likely do have some continuing adrenal issues. I find that its reasonably easy to diagnose (4-tube cortisol test, etc.) but I have not found any treatment that actual works to resolve adrenal issues. Meditation and advice like, "try to stress less" are not really tangible fixes for me.

Usually between 97 to 97.7

I asked for a low dose - like 100mg a week - for joint pain. The reply was (and I am paraphrasing, so please bear that in mind) that I would need to have x-rays proving some specific type of injuries before they could prescribe it.

Free T3 was 3.6 and Reverse T3 was 20.4. We increased my T3 dosage after that. Like TRT, I will generally look fine "on paper" but have no symptomatic relief whatsoever.

I did ask them but it was a couple years back, perhaps they have a new policy by now. (Fingers crossed)

I am with Defy and I am pretty sure they only prescribe it if you can prove an injury or something along those lines, but thank you.

I wish I could get a prescription for 100 mg a week. I have some creaky joints that could use a break.

First off, I want to wish everybody on this forum a great Thanksgiving. Anybody else here that doesn't respond to Thyroid meds? T3 or T4 or a combination of them? I have persistent and slowly worsening symptoms of hypothyroidism: Often feeling cold, I tire easily, I always have sore...

Thank you!

Does anyone know if Defy prescribes this for joint pain? I will ask them at my next consult, but that is a ways away. I have some shoulder and knee pain that I sure wish I could fix.

I have read those and the results are impressive. My only roadblock is in getting it prescribed.

Your results sound awesome. I have some old injuries that I have pretty much given up on in terms of ever healing, and if 80mg/week of Deca could help me heal them, I would jump at it if I had the chance.

This looks very interesting! Thank you for sharing.

Steady state is achieved at around 5 times the half-life of the drug (any drug). hydrochlorothiazide has a half life of 5-15 hours (depending what source you read) so for example, if we use 15 hours to calculate, steady state would be in 5 x 15 hours or 75 hours.

With daily injections there are no peaks and troughs - well, there likely are but they are so small as to be imperceptible.

Yes, 40 mcg is correct. It doesn't seem to help my LDL levels or raise my SHBG or give me more energy or really do any of the things that thyroid meds are supped to do. Weird, but not surprising to me as that is how I respond to just about everything. Novocaine at the dentist, pain meds, etc.

The capsules are mixed T3 and T4 and my daily dose now is 40 mg T3 and 100 mg T4. It looks like a lot on paper, but I cant feel any difference if I run out and it takes 2 weeks to get a refill.

I will try that and keep my fingers crossed. The thing is, I have had my dose increased 4 times since I started thyroid meds and it never seems to to change any of my numbers to any useful degree. Might be a point higher here, a point lower there - basically what looks like normal testing margin...

Metformin and Berberine (taken for 2 years) had no effect whatsoever on my SHBG.

I have been on a compounded T3/T4 combo for years and it has no discernible effect on how I feel or on my SHBG numbers. My dose has been increased 4 times and it still makes no difference. I am very careful to take it on an empty stomach with no caffeine as well - I take it before bed which is...

It had zero effect on raising mine and I have never seen anyone say it has on any TRT forum, either. The idea comes from the thought that I'd a guy has low SHBG then he must be fat and diabetic or pre diabetic, there for Metformin should "fix"him.

Need to do an attempt at restarting my HPTA axis. I was low before and TRT feels no better but having a T level near zero (if I can't restart) is not healthy. I might be stuck with TRT.

Its good to see some research that goes beyond the bro science. Sex Hormone Binding Globulin: New Science Questions Old Beliefs I have super low SHBG (averages around 10) and TRT has been a fail for me in any sense of feeling better than pre-TRT. Feels like I am interjecting water at any...

It is awesome that a twice a month treatment works wonders like that!

I wish I could get it from Defy. I am not getting any younger and I get joint pain more often these days. 100mg/week seems to really help a lot of guys.

I am thinking about trying it as well. Nothing else has worked, so I will give it a go if I can find a solid source.

This is terrific. I hope it becomes more readily available.

I used daily Prop for 18 months..felt nothing from it. No difference from Cyp. Everybody is different..some guy do well on it.