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Well, given all the recent animal data that nandrolone is cardiotoxic and neurotoxic, perhaps it is time the FDA revisits its approval of nandrolone and removes it from the US market. That will certainly solve the "should I add it question."

They did a resting Echo then a stress treadmill Echo. The values normalized on the stress echo done an hour later. More importantly, despite abnormalities, over almost 2 decades they have not worsened. My point is, echos even under the best circumstances can have considerable variability with...

Thus the importance of everyone having pre-post data, on themselves. I have had multiple echos done over the past 30 yrs. Went from normal to Grade 2 to normal to grade 2 to grade one that normalized with exercise. Considerable variability. My advice, if you have any concerns, either follow with...

No one knows if low doses of nandrolone causes LVH, it has never been addressed in humans. It just keeps getting repeated over and over along with the animal studies that suggest it occurs in higher doses and possible mechanisms. We don't know, however given decades of clinical use (200 mg/wk or...

If you stop, assuming the TRT is actually making BP worse, then what? I would ask your doc to try Lisinopril or another ACEi (get off the ARB first), titrate up and see if there is a positive effect on BP. It might cause a cough, it might not. The health benefits of TEL don't outweigh...

ARBs and ACEi have been shown to cause anemia in some populations and in some circles Telmisartan is recommended to combat HRT related erythrocytosis. There has never been a study to support that contention. Personal experience was that it did nothing for Hb/HCT related to HRT and had little...

https://www.medpagetoday.com/meetingcoverage/obesityweek/101586?

Tendon risks associated with Cipro use have been overstated and the mechanism has been called into question. Still, last resort, but if needed it is needed and understand cephalexin carries similar risks as levofloxacin but not ciprofloxacin. Association between tendon ruptures and use of...

Ref Bhasin's study on older men (60-75 yrs) and graded testosterone dosing up to 600 mg/wk for 20 wks. JCEM 90:678, 2005, that will answer your questions relative to T and the prostate and muscle mass. If you were already taking 100 - 150 mg/wk, the androgen receptors in the prostate are...

https://tahomaclinic.com/Private/Articles2/Taurine/Eby%202006%20-%20Elimination%20of%20cardiac%20arrhythmias%20using%20oral%20taurine%20with%20l-arginine.pdf

Keep govt out of most everything and we'd be in a better place overall.

The problem with anastrozole is the half life, around 48 hrs. If you take 2 mg a week, you're crashing your E2 right after then it soars right before the next dose, no wonder you're an emotional train wreak. There are much better ways to manage E2 IMO but not anything that is available in the...

Good post Big Tex.

We're talking competitive athletes (drug tested). Of course RE is necessary to optimize the effects of not only HRT but anything more. One of the driving reasons AAS and T were made into controlled substances dates back to the Ben Johnson scandal with stanazolol. Congress had one thing in mind...

Had Urolift done 3 1/2 years ago, very modest improvement. 4 implants. Could not stop flomax. Prostate currently 97 grams with medial lobe. Will have a HoLEP next month at the Cleveland Clinic. Other option was Rezum but recovery with a large prostate can be brutal and outcome uncertain. The...

About 89% of AAS users are not athletes, they are cosmetic users and 52% use between 200 - 600 mg/wk, 31% between 600 - 1000/wk for a cycle (Cohen et al 2007). Until we put these drugs back in the hands of physicians that truly understand them, allow them to prescribe and monitor short/long term...

Use Cystatin C for renal function, not creatinine.

The studies done on 200 mg/wk of T for male contraception yielded mixed results, very high genetic variability, some men were shut down, others were not. Running HCG concurrently can prevent infertility, but I wouldn't bet the farm on it. If you're going to use HRT or run a cycle for cosmetic...

"The same symptoms can be from a tight pelvic floor" Ask your doc for a script for physical therapy and someone that specializes in pelvic floor dysfunction. The two docs I have spoken to (one at Ohio State and the other at the Cleveland Clinic) feel that most of the BPH symptoms come from a...

Figure 2. Exactly why using a 5-ARi is a bad idea.

Been my view for a while now. Very few doctors I trust and zero trust in lawmakers and politicians. There was an article in MedPage by Harrison Pope MD, MPH. He coined the phrase Muscle Dysmorphia long ago, also comic book terms like The Han Swolo Effect. Suggests treatment involving high doses...

I would like to see the "studies" that show soft plaque buildup from HRT (T).

I posted the following reply to a researcher from one of the academic groups I belong to. She asked why monitor an AAS user. "The importance is knowledge. What we know with some degree of certainty is that bodybuilders that polypharmacy (including rec drugs, stimulants, alcohol, etc.) who want...

ARB or ACEi, most user friendly esp for active guys. Primary driver for LVH/fibrosis and remodeling is ANG II/ALD.

Well then, I read that wrong. Those labs at the end of a 12 week run of 25 mg/d of OX are not bad, HDL is higher than I would have expected, and I have seen this on labs from others running OX, but for some their HDL is in the low 20's or upper teens on just 10 mg/d. LFTs look fine. I will be...

The question is, what do your labs look like at the end of 12 weeks of 25 mg/d of OX, in particular GGT, ALT and lipids. Your LDL and non HDL are high wo OX, your HDL is likely tanked on OX and perhaps LDL higher. Long term that just isn't a good combo. If you have a zero score on a CT angiogram...

Oxandrolone will do the same and more, been used in humans for decades, FDA approved, has an excellent safety profile, and available compounded for less than $100 for 90 x 15 mg caps. IMO, there are reasons why they are not FDA approved.

Well said and summarizes what we know about SARMs to date. No reason why anyone should even consider taking them.

Nelson, also suggests effects of LH that go beyond just increasing T and why adding HCG to HRT is beneficial as it suppresses LH. Thoughts?

In Bhasin's 2005 study of graded T dosing in older men there was no significant change in SHBG in dosing up to and including 600 mg/wk that resulted in a total T of 3286 ng/dl. If you compared the change in the means, while not significant there was a 15 - 25% decrease in SHBG with all dosing 25...

Try Berberine 500 mg twice a day. Give it 3 mo and see if it has a measurable effect (about 20% decrease). May also reduce trigs.