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  1. W

    Podcast about SLU-PP-332; GLP-1, GIP, and glucagon (single, double, triple) agonists; and SARMs

    Been hearing alot about SLU on a couple of forums. Some are replacing CLEN and DNP with SLU with less overall toxicity and good non-stimulant results. Blood chems have been unremarkable to date. Would like to see at least a P1 safety study in humans first though. As stated in the video, still a...
  2. W

    CJC-1295 vs Ipamorelin vs Tesamorelin vs hGH

    CJC-1295 wo/DAC t 1/2 is about 30 min. With DAC, 6 - 10 days. Anecdotally, HGH EOD 3 - 4 IU at bedtime, CJC-1295 no DAC + IPA 200 - 300 mcg ea days in between HGH, one day off each week. Will increase circulating IGF-1 2 - 2.5 x and sleep quality is excellent. Retatrutide 1 - 3 mg/wk total in...
  3. W

    Tirzepatide vs Semaglutide: Pros and Cons

    Retatrutide will be the next blockbuster when approved. Far less GI sides (lower GLP-1 activity), none at lower doses, and activates the glucagon receptor that enhances fat oxidation. Many of the sides of these drugs are simply bc doctors don't know how to use them and patients expect miracles...
  4. W

    Estradiol opinion!!!!

    When using nandrolone, to get an accurate T value you have to use the LC/MS-MS assay, not the standard T assay. Nandrolone has significant cross reactivity with the standard assay. That E2 is fine, but the dosing of ND is excessive.
  5. W

    A New Frontier in Diagnosing Low Testosterone: The CAG Repeat Game-Changer

    Carruthers hit on this topic among a large number of other variables that can drive sensitivity to testosterone in a 2008 paper. Carruthers M. The paradox dividing testosterone deficiency symptoms and androgen assays: A closer look at the cellular and molecular mechanisms of androgen action. J...
  6. W

    Study Solves Testosterone’s Paradoxical Effects in Prostate Cancer

    https://corporate.dukehealth.org/news/study-solves-testosterones-paradoxical-effects-prostate-cancer Probably explains why MTF trans have a 2 fold reduction in PCa but higher PSA when Dx, and why 5ARi reduce PCa risk but increase Gleason score cancers once they are Dx. No androgens present to...
  7. W

    Cialis and Alcohol

    Headache. I've used 4 yr exp cialis, worked just fine.
  8. W

    Test cyp plus HCG - high estradiol

    No E2 Sx. I don't vary the HCG schedule, M and R regardless of when the TC/TP shot falls. Last total T with this same protocol was 850ish. I don't micro manage T or E2, even when I did, it made no difference. Labs on Day 4 after a shot. Total T ranges between 700 - 1200. Have had HCT issues for...
  9. W

    Test cyp plus HCG - high estradiol

    My last total T was 1056 ng/dl, E2 102 pg/ml. Doing fine. Use 100 mg TC/20 mg TP every 5 days and 500 IU HCG twice a week.
  10. W

    Infrequent dosing to avoid shutdown…

    Give it a try and let us know what happens.
  11. W

    Infrequent dosing to avoid shutdown…

    "For example, some compounds (e.g. oxandrolone and (i think) turinabol) are not not particularly suppressive." 15 mg/d for 5 days of OX will knock your circulating T down by about 40% (Sheffield-Moore 1999). All androgens or SARMS will shut you down, fast and in very small doses. Bro Science...
  12. W

    Doc prescribed HCG and Test C

    LH/HCG does more than just stimulate testosterone, neurosteroids are involved and why some guys feel better when HCG is included. HCG has about a 2 1/2 d t 1/2 if I remember so twice a week would be fine. Max stim occurs with about 750 IU. IMO, start it with the T vs trying to play catch up and...
  13. W

    Excessive androgen exposure and risk of malignancies: A cohort study.

    You are forgetting, MTF have their T levels crushed along with anti-androgens. That is now a very high E2 to T and DHT ratio. If you look at Glaser et al studies, T is neutral to protect against BCa in women, and decades ago they would give Test P to women for metastatic BCa to slow the...
  14. W

    Excessive androgen exposure and risk of malignancies: A cohort study.

    Abstract Background: A link between androgen use and the risk of cancers, especially prostate and breast cancer, has been suggested. The knowledge about a possible association is limited. Objective: The study aimed to investigate cancer incidence rates, particularly those related to prostate...
  15. W

    Where to get Testosterone prescriptions?

    My non-medical two cents. GoodRx 10 cc 200 mg/ml is about $40. This business of HRT clinics is the equiv of pill mills for opioids IMO and they can rape you on cost and unnecessary labs that they get kick backs on bc they can, knowing most docs either won't or under treat with T. I've seen...
  16. W

    Whats wrong with me...

    Did the scan include the vestibular nerve and they ruled out acoustic neuroma?
  17. W

    Anemic with very low BP's since starting trt gel

    It's not the gel and drinking more water will drive it lower, not higher. I'd follow up with your doc and make sure nothing else is going on (occult blood loss or anemia of other origin). Gels have the least effect on Hb/HCT, inj esters the greatest.
  18. W

    Impact of TRT on Adverse Cardiovascular Events in Men with Low Testostosterone: Evaluation of Physiological and Supraphysiological T Levels

    The question is, is it the increased HCT, or is there something else going on (genetic predisposition with increased T independent of increased HCT or combined risk factors) that is driving this. Nadeem et al, 2013 showed that secondary polycythemia in COPD patients (HCT 53.5% vs 43.6%) was not...
  19. W

    Impact of TRT on Adverse Cardiovascular Events in Men with Low Testostosterone: Evaluation of Physiological and Supraphysiological T Levels

    They didn't have baseline iDXA data, it may well be as they mentioned in the article, higher activity following HRT and they may have lower BMD and are at higher risk of fractures because of low T and likely E2, compounded with less activity.
  20. W

    New member Estradiol Concern

    The only way to effectively manage E2 is with a non-aromatizable androgen in place of some T (some depends on how much you aromatize). In an ideal world, if it were available compounded, drostanolone enanthate. Same relative t 1/2 as TE or TC and can still maintain the anabolic equiv of T in...
  21. W

    Cypionate vs Propionate for daily injections

    The ester form of T is a prohormone and is inert, in the end what is released after the esterase acts on the ester is testosterone, the active form. The ester simply dictates the rate of release of the active hormone. Prop will give you a shorter duration of action but higher blood concentration...
  22. W

    CJC-1295 / Ipamorelin (10mg) blend dosage

    First how much total volume will the vial hold? For PS, 2.5 ml is about it. Second, what dosing are you going to use of each peptide? Regardless of what volume you reconstitute, the ratio will be 2:1, IPA/CJC, respectively, if that is what you want. If you want equal dosing per inj of each, the...
  23. W

    TRT prescriptions and BS about the state I live in.

    10 mg 200 mg/ml Test C generic is about $40 Good Rx.
  24. W

    Cypionate vs Propionate for daily injections

    Feel my best with 100 TC and 20 TP every 5 days, and 500 IU HCG twice a week. Haven't checked my T levels in years, wouldn't change anything regardless. Post 1 1/2 yr HOLEP PSA 0.32. Phlebos about every 10 weeks, HCT < 52%, all other blood chems and lipids good along with BP. E2 runs 90 - 100...
  25. W

    Issues with Empower Pharmacy

    One of the guys on another board had his Empower ND tested HPLC, came back around 190 mg/ml. There are simple colormetric tests such as Roid Test that the BBs use for their gear. They make a quantitative and qualitative tests for testosterone esters (C and E) and ND. Crude yes, but they get you...
  26. W

    Problem reconstituting Puretrig HCG...

    I use Pregnyl. Take a 10 cc syringe and 23 - 25 g 1", generally the vial to be reconstituted has some over pressure, I'll draw about 5 cc of air from the HCG vial and create a vacuum, then fill the syringe with 10 cc of BAC water (MC makes a good point regarding saline vs BAC) for multi dose. Be...
  27. W

    High estradiol levels on TRT

    Think ratios, not absolutes. In very rough terms, 76/8 = 9.5, 162/17 = 9.5. Leave it alone. The system is working as it should be.
  28. W

    RBC won't lower, what else could it be?

    Thanks. The girlfriend just received one. We did the alcohol experiment, yes = trainwreck.
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