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  1. M

    Latest Update on Metformin

    Observations being on ER-Metformin for last 4.5 mos. (started July 1, 2022) 15lbs weight loss - no change in diet or training No GI problems up to 2g/day No change in fasting glucose levels or a1c (not diabetic to begin with) *Substantial decrease in total and free T (not on TRT): June...
  2. M

    TOO MUCH T3 FROM NDT = JOINT PAIN?

    Observation - Progressive increase in blood pressure/pulse averages: last 12 mos: 127/79/63 last 6 mos: 126/80/64 last 3 mos: 128/82/68 last mo: 131/84/67 causes: increasing NDT>increased serum T3 = elevated BP/pulse?
  3. M

    TOO MUCH T3 FROM NDT = JOINT PAIN?

    Have been doing it before for the last several labs this year to measure the effect of the dose.
  4. M

    TOO MUCH T3 FROM NDT = JOINT PAIN?

    When you say to keep your FT3 levels high, how high? I, too, have lately been doing my labs the same morning I take my NDT dose to see how the medication is working. And it is working as I can tell from the labs I posted on above. I guess I shouldn't be concerned with being a bit over range on...
  5. M

    TOO MUCH T3 FROM NDT = JOINT PAIN?

    That one relates to TSH over-suppression. Fortunately, not my problem. In fact, my issue has been high normal TSH and trying to suppress it more by gradually increasing the dose of NDT which it appears I have done. That latest level of 1.23 is right around where I need to be.
  6. M

    TOO MUCH T3 FROM NDT = JOINT PAIN?

    Didn't get rT3 tested this time, but I usually hover around 19 (but that was at a lower dose of NDT). Will test again soon. What I really am curious to know is whether too much T3 can accelerate cartilage degeneration which would give rise to OA and injuries. Maybe it's completely unrelated...
  7. M

    TOO MUCH T3 FROM NDT = JOINT PAIN?

    Never have had an indication of Hashi's from dozens of past labs and ultrasounds and as I indicated, I am on NDT, not Synthroid.
  8. M

    TOO MUCH T3 FROM NDT = JOINT PAIN?

    Latest labs (last dose of 2.50 grains (162.50mg) NDT taken only about 6h prior to draw): TSH:1.23 ref range: 0.450-4.500uIU/mL FT3: 5.00 ref range: 2.0-4.4pg/mL FT4: 1.60 ref range: 0.82-1.77ng/dL Anyone notice that too much T3 from desiccated thyroid causes a flareup in joint pain? Is a 5.0...
  9. M

    Add Metformin to TRT

    My 4-month trial of Metformin (1.5g) proved me right: For all the wonderful health and ligevity-enhancing benefits, I' experienced a 36% drop in total testosterone since starting which I knew about and several studies have shown. I was already low normal (high 400s) which was not optimal, now am...
  10. M

    GH SECRETAGOGUE PEPTIDES & IGF-1

    I am 99% certain my high normal (for my age of 62) of 258 is from eating a diet in which my protein is mostly all from non-plant sources (cultured dairy, eggs, lean meats, fish, poultry, whey) + supplements like DHEA + training. I prefer this type of protein over anything plant-based. This...
  11. M

    GH SECRETAGOGUE PEPTIDES & IGF-1

    Anyone have data showing that if one's natural IGF-1 level is high normal for one's age as in my case (see below), would GHRH/GHRP peptides be contraindicated since they raise IGF-1 over time? The concern is not as bad as with straight GH, but is still an issue for long-term (cancer, CV disease...
  12. M

    Upped dose of NDT and my TSH went up!

    How is it possible that I can take a higher dose of NDT and do my labs at the same time as prior and come out with lower TSH and T3? Prior labs (NDT dose @ 2.00 grains - 130mg): TSH: 2.03 FT3: 3.70 FT4:1.40 Current labs: (NDT dose @ 2.25 grains - 146.25mg): TSH: 3.29 FT3: 3.5 FT4: 1.5 No...
  13. M

    METFORMIN - no change in glucose readings

    Has anyone seen better glucose results with immediate release v extended release? I also wonder if my 1.5g ER-niacin could be suppressing the effects of metformin. Metformin and Niacin SR Interactions - Drugs.com
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