Search results

It was my first time testing for the new regimen so I did it on a Monday before my daily test injection and at 3.5 days since my last HCG injection. I was prepared for my peak to be much higher than that though. I didn't even think it could get that low only 24 hours after a daily injection.

After conferring with my doc I got him to switch me to daily injections after dealing with a decrease in SHBG and huge increase in E2. Was injecting 70 mg test and HCG 500 IU twice a week now 20 mg test a day and no change in HCG. Baseline labs were 1060 TT, 18.5 FT and 41.8 sensitive E2...

I have been on TRT for 2.5 years and have had textbook levels - TT around 1000, FT in the 20's, SHBG fluctuates between 45-50 and E2 typically matches SHBG. I have never had any E2 symptoms though I will admit that my regimen would create an E2 nightmare for most - test cyp 60 mg every 3.5, HCG...

Keto isn't reducing your metabolism. YOU are reducing your metabolism. Step one is determining your basal (or resting) metabolic rate which you can get via hydrostatic testing, dexascan or by googling an equation. I am 100% certain your BMR is higher than 1500 calories. From there you add...

I received my first vial of PT-141 from my physician and tried my first dose at 0.1 ml as per his recommendation - injected sq into my belly with a 31g 5/16 needle. I took it at about 8:00 PM as I wanted to see what side effects might be before sleep. As reported by others I experienced very...

It's actually available in compounding pharmacies right now. I was shocked to see vials on Amazon though I am not sure how reputable to seller is.

This is exactly how I am looking at this. I have done all the work. Regimen is solid. Labs are good. Fitness/body composition is elite level for my age. I have no medical issues that would lead to ED. I just think I have the libido of a healthy 50 year old and I would like the libido of a...

There is an astonishing lack of talk on here about a drug which attempts to address something that we talk about all the time and have zero tools to fix - libido. Now that we have multiple phase three studies to review on Pubmed and an FDA approved product perhaps we need to start gathering...

Vince I was just curious if you could expand on your opinion on why the pro-hormones are unnecessary. Dr. C was always very aggressive with my DHEA, 25 mg twice a day, DHEA 365 (71-375 scale) but I don't know that i have ever actually discerned a difference. I take it anyway because it is...

My libido improved when i added the cream but truth be told I think it was a honeymoon period and then I adjusted. Libido is a funny thing. I just turned 50 and if I had to guess I have an average libido and have relations with my wife more often (2-3 times/week) than most couples who have...

I should also state that my DHT an hour after morning cream/Natesto application is 243 on a 30-85 scale. I'd love to see how it cycles throughout the day but the cost of testing is prohibitive.

The thing I wonder about now when people talk about levels they can tolerate is are they talking about peaks or troughs. When I was running troughs on injectable T of 800 to 1000 I felt fine I just couldn't sleep and I had terrible acne. Now on Natesto and cream I measure peaks which are also...

I just turned 50 last week. When I was doing injectable test I typically ran troughs around 1000 with a free T around 25, SHBG and Estradiol around 50 ish. I have no idea what my peaks were I never measured them. That was on 80 mg twice a week. On Natesto and cream I now run a peak around...

Absolutely 100% better

Even though my HPTA is beyond restart due to age, high SHBG and time on TRT I went with Natesto as a way to solve some of the problems I was having with injections, namely terrible acne and inability to sleep more than four hours a night. It did work for both of those things but what I found...

I specifically asked him about it because I was unhappy with libido and he thought my DHT levels could use a little boost. He had a lot of great advice around stuff like that and in this case it was very effective.

Vince My doctor could care less about intricacies like this. Because of where I am I am relegated to nothing but testosterone mills as treatment options. It was Dr. C when he was with us who modified my regimen with the addition of test cream, HCG, DHEA etc. Where I live these doctors...

I had very similar disappointing results with injections. I was extremely disappointed with the lack of sensation down there and the weak orgasms. Sometimes they didn't even feel like orgasms at all and that HAD to end because like most of us that is an important part of my marriage. I hate...

I have been on TRT for about 2 and a half years and am pretty rock steady on a regimen that works for me. Labs are good and I have resolved my side effects which in my case were horrible acne and sleep issues. I am currently on Natesto, 50 mg of test cream applied once a day to the scrotum...

My injection protocol was 70 mg test cyp twice a week sub q but I am not doing that now. I remained on Natesto and 500 IU of HCG twice a week and added two clicks of testosterone cream applied to the scrotum every morning. That got me over the top and I feel the best I have in two years of...

I have only ever struggled with experiences like yours when my estrogen is low. When it is in the 40's which is where I typically run erectile function and sensitivity are normal.

It depends on how high your SHBG is. If it's low you may deal with estrogen issues. If it's high then you won't have to deal with estrogen symptoms. I use 500 IU of HCG every three days and run what most would consider a high E2 but with a SHBG around 50 my free E2 has always been dead...

I was curious about the pharmacokinetics of Natesto - the quick peaks and the constant fluctuation in hormone levels. I remember Dr. Crisler talking about how hormone variations are "part and parcel of youth." It just couldn't overcome a SHGB of 50. I haven't given up on it though. My doctor...

My SHBG and sensitive E2 numbers almost exactly mimic yours and I am also a 40 something with 11% body fat. E2 is just like testosterone, the only one that matters is the free version and with an SHBG like ours you can run a sensitive E2 over 50 and still have a free E2 within normal range...

Science writers don't typically end every other sentence with exclamation marks. Also PPAR Gamma activators (i.e. thiazolidinediones) have been used for years to treat type II diabetes and metabolic disease. Up-regulating PPAR gamma lowers blood sugar and serum triglycerides and reduces...

I am in the US. I used as prescribed which is three applications per day. I also find a protocol like you mentioned interesting but I think I would be the first - have heard zero about that. Natesto is such an interesting product because of all the delivery methods it most closely resembles...

I am just finishing my fourth month of Natesto therapy and am calling the experiment complete. I am going back to injections. My goal was to see if I could restart my HPTA which was a common occurrence in the extended clinical trials but my FSH and LH are still unreadable. I would give it...

I had the same issue when I initiated TRT. I have been a solid sleeper my entire life and suddenly I was wide awake at 3:00-4:00 every night. I tried all the supplements mentioned on here and several prescription meds. Eventually I switched to Natesto for other reasons and one of the benefits...

Have your primary care physician order you a pelvic ultrasound. The tech will know in the first 30 seconds if you have a varicocele or not. The test is easy, quick and cheap. I had two large varicoceles which I had removed using the newer radiological procedure. My TT was in the low 400's...

For what it's worth Dr. C was my doctor for a while and he was the one who started me on daily HCG (along with Test Cyp) AND dosed DHEA very aggressively. He liked to shoot for DHEA numbers in the very high range or even over. For a while he had me taking as much as 75 mg a day of DHEA (I take...

I have not seen or read much on here about Natesto. I am giving it a trial run and thought I would share my experiences in an effort to get some info out there. Brief history: On TRT for 20 months High SHBG guy (44-50) Best injection regimen was 80mg twice a week and HCG 150 IU daily (TT-1000...