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The first time I used it I tried the overnight effect and took it before bed. The effects were so powerful that it made sleep very difficult.

My vial is close to three months so perhaps that is the issue. In any case the initial effect was encouraging enough to try another vial. May I ask if you had any issue with side effects? I experience a little flushing and a hint of nausea shortly after injection. Both are mild and...

I am afraid I have to politely disagree with you. PDE-5 inhibitors move blood via their effect on NO, PT-141 exerts an entirely different effect on the melanocortin system. I use cialis as part of my daily NO stack. My initial experience with PT-141 was that the effect was dramatic and...

Has anyone experienced diminishing effect from Pt 141 over time? It worked extremely well for me the first few uses but got less and less over time. The side effects, nausea and muscle soreness, did not decrease. The vial, which I keep refrigerated, is a couple months old. Could it degrade...

That was my understanding of daily dosing as well - that it was for low SBGH only. It was after consulting with Dr. Saya that I decided to go with dailies mainly because of side effects - in my case hematocrit, acne and sleep trouble. I was on that downward trend of high hematocrit, the need...

The main difference was that after I recovered, which took weeks, my testicles no longer hurt. I do a lot of weight lifting which caused blood to pool in my varicoceles and resulted in a constant dull ache. I chose to begin TRT right away despite the surgery because I was suffering from...

I did not check sperm counts before or after as I was 48 at the time of the post and not interested in having more children. After this I consulted with Dr. Crisler (RIP) who advised that HPTA restarts are doomed to failure for most guys my age which makes sense. Now I am with Defy and using...

Also the data shown in figure one demonstrate that their own data does not support the conclusion that "In conclusion, higher IGF-1 levels and bioavailability predicted mortality and morbidity risk." For the non statisticians on the board when the lines on either side of the data point, known...

While interesting this study looks at one of the most specific and genetically homogenous populations in the world, the Ashkenazi Jewish population. The medical/science world has long focused on this population because of it's longevity, it's relatively high incidence of some interesting...

Just curious what in particular about your TRT therapy you are struggling with. Although daily injections may have originally been prescribed as a solution for patients with low SHBG they may be of benefit to men with normal SHBG as well. After digesting all of the information on this forum...

I started at 20 mg a day but my TT went from 1000 to around 1500. It is standard practice to drop the dose with dailies. I think it is pretty well established that for most men TT levels are maintained at adequate levels with a smaller overall dose.

Daily injections were the solution for back acne for me. I was on 140 mg a week now on 16 mg per day and my back is clear when just a few months ago I was reluctant to take off my shirt. I think those big peaks in DHT are what put you over the top on acne. Just tested last week and ran an 870...

I'd have to check the dilution but it was .2 ml of the Tailormade and .4 ml of the Hallandale injected sub Q with a 31 gauge needle every night before bed. I have almost finished the second vial and will discontinue at that point but will not hesitate to go back to it again if needed.

I am just finishing a couple vials of BPC 157 - from Tailormade and Hallandale - and was so pleased with the results that I am even doubting myself. I am a molecular biologist and like to think of myself as somewhat immune to the placebo effect as I am familiar with all the current data and...

Back Acne was by far my worst side effect after starting TRT. It was just awful - unsightly and itchy and just nasty which was especially frustrating because my physique and everything else was otherwise very good. I tried everything: antibiotics, carnitine/pantethine, shampoos and soaps...

Going to daily injections lowered by hematocrit from low 50's to 48 and I am 90 days in.

In terms of how I "feel" I'd have to say there was little difference. Aside from the aforementioned side effects I have always been extremely active and high energy. I will say that one of the reasons I moved to Defy in the first place was what I considered a lower libido, for me anyway, and...

My numbers are 70 twice a week were much the same. Last labs were 1040 total, 22 free, 73 sensitive E2, 32 SHBG. Interesting to me that I can reach the same numbers on so much less testosterone. As for ED vs EOD Dr. Saya seemed to be just a big believer in the ED regimen, and I have no issue...

At my current albumin level the calculator gave me a free test of 38 - literally twice my free test reading. This is fascinating. I was not aware of the Tru-T calculator so I thank you.

On the advice of Defy I switched to a daily protocol 12 weeks ago. I was on 140 mg of test (70 mg twice a week) and 150 IU/day of HCG. I now inject 18 mg of test daily w/ no change to HCG dose. I just ran my first labs after 12 weeks. In terms of side effect management it has been a complete...

I was in a similar situation as yourself. I don't know your age but I am a 50 year old Crossfitter. For my first year or so I was a three day a week guy as well as Crossfit can be pretty high volume on the shoulders and the weights get heavy as does the intensity. I remember being shocked at...

I don't know that TRT increased my overall strength by that much. What it did do is allow me to engage in extremely hard Crossfit workouts for an hour a day six days a week. I could not have done that before to the same degree I do now. My recovery time is pretty good for an old guy thanks to...

We are basically twins - I am just a few weeks of pizza away from 259, and I could not agree more, bench press is an overrated movement and clearly not a functional movement. Furthermore guys who do it for a lifetime almost invariably develop shoulder problems from it. I will admit this - I AM...

I am actually 6'5" and wouldn't call myself wiry but I am slim in the waist - I have a 36 waist and wear a 52 XL coat. You are right I have never been a good bencher due to poor leverage. I absolutely hate that exercise and always did even when I was playing college football. My max bench was...

I use 29 gauge half inch insulin syringes and inject around the navel. I also inject HCG 150 IU daily using a 31 gauge needle and now I am injecting ipamorlin/cjc-1295 five out of seven days as well. It is a lot of injections but I don't mind.

Yes I use test cyp. I agree that theoretically a daily application seems unnecessary with a half life of eight days but in practice the results are better, for me anyway, than twice weekly.

Just to chime in from a different perspective - my upper body looked very similar after a career as an Army officer (running every day, no weights) which is not a bad way to look in your 50's but not exactly muscular either. I started doing Crossfit four years ago which includes no machines or...

Sleep was one of my main complaints after starting TRT almost three years ago. There is no worse feeling than waking up at 3:30 every morning wide awake and knowing you won't go back to sleep then being exhausted all afternoon. The fix for me appears to be daily dosing. I switched to that two...

Just received my first vial of ipamoreline/cjc-1295 from Tailor Made and it came reconstituted. I did not realize it until I got home and went to mix it. I HOPE it was shipped on ice but I don't know as it shipped to my doctor and they had it waiting for me at room temperature. Is this...

I am using the same half inch needle that i used for twice weekly for daily, but twice weekly I took in the shoulder and now I am doing them in the belly.

Yes that is correct. I basically always draw blood first thing Monday morning because Monday morning is always Test and HCG. Also the 1060 was my last labs at two 70 mg shots a week before I switched to daily.