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No, no use of an e blocker (aromatase inhibitor). Using a mixture of cream and injectable, appropriate for the patient usually avoids any need for an AI. (AIs have often been used when poorly designed protocols send Estrogens way high and out of balance with Androgens). There is an excellent...

Home country is England where Proviron was prescribed. Big chunk of the year I live in Morocco where it's o.t.c. Don't know what the chances of it getting licenced in US are. Probably not great as it's been generic for years and is cheap as chips so commercially unlikely. Maybe physicians would...

I've seen mention of Dr Shippen here on Excelmale and he's clearly held in great esteem so good for you that you're working with him. Those numbers work well for me too. It's what puts the "sex" in we sexagenarians!

I've used (prescribed) Proviron for ~20 years. On average I would use 150mg per day (6 x 25mg tabs) which I believe normally elevates the serum level of DHT by about 20 to 25ng/dl. To add really significant amounts you'd need a lot of tabs: each tab is around 25 cents. It will also displace E2...

Agreed that T:E ratio is probably not a good indicator of overall function. As it happens if a guy reporting good function at a given T:E ratio knew his 5-ar conversion he would thereby know his DHT:E2 ratio which could be of more significance. More importantly Friday afternoon hereabouts is...

In saying "ratio" I really mean the balance or relationship between DHT and E2. I realise that Suggesting a numerical ratio wouldn't be of statistical relevance unless studied. It does makes sense to me that a Ratio of DHT to E2, the 2 metabolites of T, would have significance in measuring...

It sounds as though your prescribing Doctor has left the application site(s) of the T Cream up to you in which case my suggestion would be to initially split each daily application, say 50/50, between scrotum and another site. If you use too much of the product on scrotum you may send DHT...

Then you're in Europe? If so have you considered/used Proviron (mesterolone). As you say you probably only need to boost DHT a bit. Thanks, never heard of Testavan so I'll have a look.

I suppose if levels were good at 100mg a week and say, for simplicity, that TT was around 1000ng/dl and if you were adding one sachet of a transdermal T Cream daily then you'd need to reduce the TCyp dose by the expected increase in TT from the cream. So if the cream would give say 300ng/dl (30%...

Thanks for the links @Nelson Vergel I've never had a sensitive E2 test as I've never been to a Lab that offered them. I'm looking forward to getting the Test done at Discounted Labs when I'm in the US later this year. I am a total convert to the benefits of E2. Below is what I wrote recently...

Possibly worse than the knacker cracker at Brize.

Thanks for commenting Nelson. I appreciate all you do for men's Health and the opportunity to participate on your Forum. I've recommended Excelmale to several contacts - particularly my doctor. I have to say that "blocking" E2 is the very last thing on my mind - keeping it at an adequate level...

That's essentially what brought me to Excelmale - the fact that in the US Proviron etc are not licenced and therefore there is the workaround of significantly raising DHT by applying T Cream direct to the scrotum. The question I was raising, and you responded to my previous post, was is there...

I believe the reason DHT has often been disregarded as TRT has evolved owes much to the background of many of the leading practitioners. At BobyBuiding levels of exogenous T there will never be a deficit of DHT and when it does become an issue its probably because it "caused" problems, notably...

My contention is that TRT as it is widely practiced is failing many patients, gives sub-optimal results to others and oftentimes, where it does "work", works almost by default. If a guy is symptomatic and is diagnosed as low T he is often started on a regimen of an aromatisable Testosterone...

That seems a big drop in the T Cyp but your Doctor clearly knows the transdermal product, has your SHBG and your health history so is well placed to make the calculation and ensure that you maintain adequate levels. If you're concerned about your levels dropping too low you could discuss with...

If that Gel is what's available to you then why not go with that. The inner thigh is potentially a good application site and you could test a tiny amount on the scrotum. Whether you use cream or gel I would suggest that you appropriately reduce the amount of the injectable T. If you add the...

1) T Cream compounded is usually preferred: efficacy/absorbency/cost and comfort - alcohol in gels can irritate sensitive genital skin. 2) There are no "rules". Adding a measure of T Cream to your usual dose of T Cyp will raise your TT and, by aromatase, your E2. Effectively you're increasing...

An Epiphany! Precisely what we've been talking about here on Excelmale for the past several weeks. Indeed. The changes in protocols that Dr Chrisler is now proposing are precisely those that I advocated in post #7 of this thread. I've made my point many times before to no avail so it is...

The theory makes some sense to me - Finasteride is a 5-ARi - but the reduction of the DHT:T ratio by attempting to balance your hormones from the top down with Finasteride seems a horrible proposition. Finasteride is potentially any man's Kryptonite. Have you considered/tried hCG? With your...

I get you. You seem to have your sensitivity to the androgens well measured. If avoiding/slowing further hair loss is the priority then I guess keeping androgens at a lower but sufficient level would work. It doesn't take high levels though - women get androgenic alopetia too. The potential...

If the 100mg was all from injected T then 110 with a total in the 700s would seem slightly high but not if some was from transdermals. Reasons for higher than average conversion could include exposure to endocrine disruptors, other pharmaceutical/drug use, synthetic steroids, having higher than...

It's not the T to E2 that is the issue in this context it is the DHT:E2. In the case of your example of a guy with TT of 720 and E2 at 23 he could be doing ok, from a hormonal perspective, if he had DHT in the 60's which would seem around average for 5-ar conversion. Problem is that, as with...

In your position I would consider (at least initially) applying the cream to differing sites and not using 100% of the product direct to the Scrotum. Maybe 1/3rd to the scrotum and the remainder elsewhere. Depending on absorbency and the level of 5-ar activity you may risk sending DHT...

Not sure from your post if you're on a protocol and are shutdown? If you are and therefore any potential suppression isn't an issue then starting with a low dose, as you say, and evaluating would seem ideal. For sure include DHT in your bloods. Although serum levels of DHT appear only to give...

That's a really interesting and I believe instructive post. You inadvertently reduced your inj T dose by around 30% with no negative subjective response and only Labs revealed your dosing "error". Most importantly you felt good and hugely increased your chances of keeping aromatase, prolactin...

I'm a guy who loves his E2 - it's neuroprotective, maintains my bone and muscle mass, helps makes me an amazing lover and even assists me in completing the Times of London crossword each day. I don't want anyone or anything inhibiting my aromatase. So no use of AIs on my part. I believe the...

Exactly that. And you put it far more succinctly than I managed! I see incresing DHT as the best candidate - the strongest of the androgens it can't aromatise and binds preferentially with the E2/SHBG receptors allowing more free T. I don't think physicians will rush to design protocols that...

For sure. "Back in the day" before the advent of arimidex and aromasin Proviron was used for that purpose as it binds preferentially with the receptors.

I'm fairly new to the Forums and have been researching primarily to plan my future protocol in hormone therapy. Previously I have used direct DHT treatment by way of Proviron (mesterolone) which I had prescribed in the UK, my home country, and is available to me o.t.c. where I live now. My...