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  1. Jason Sypolt

    switching clinics to get away from test/anastrazole mixture and Gonadorelin

    Cataceous, I have heard the phone calls and seen the emails. No, as I said before, I cannot share them. You are intelligent enough to know why and understand that. The drug is not being used according to the FDA indications with the associated side effects when used for those indications. The...
  2. Jason Sypolt

    switching clinics to get away from test/anastrazole mixture and Gonadorelin

    Do not take the gonadorelin. Some clinics like Royal are pushing that when they can’t get HCG to keep their profits up. There is NO substitute or replacement for HCG. I can’t tell you how many times I have heard of people begging to get away from gonadorelin and they are scared of what it is...
  3. Jason Sypolt

    Testosterone No Good After 28 Days???

    Not great at all and that is exactly how some enforcement works unfortunately for various reasons. There are pharmacies and “clinics” who know that they won’t be noticed or caught doing something incorrectly or outright against the law for a long time - long enough to make it worth the effort...
  4. Jason Sypolt

    Testosterone No Good After 28 Days???

    Well, the question of what would an entity such as Defy do is something that should be directed to a pharmacy or compounding pharmacy. Defy is the doctor providing the script such as dispense “#1 5mL of Testosterone Enanthate…” A pharmacist can choose to do that, or they could choose to...
  5. Jason Sypolt

    Testosterone No Good After 28 Days???

    Parts of USP standards, and in particular the NF standards are enforced by the FDA under federal law, yes. USP is itself independent and a non-profit organization. The standards have nothing to do with dispensing medications; they have everything to do with defining standards to stability...
  6. Jason Sypolt

    Testosterone No Good After 28 Days???

    The 28-day lifespan of a multi-use vial is based on guidelines from the CDC regarding contamination and sterility. The retail pharmacies are corporate entities and are going to create corporate policy around those requirements in an effort to do anything to reduce their liability and exposure...
  7. Jason Sypolt

    Compounded HCG now banned in California?

    I wasn’t able to get more information before the weekend. We just found out Friday afternoon and this goes into effect on Tuesday, June 15. No compounded HCG will be permitted to ship to an address in CA and no compounded HCG will be permitted to be made within CA. So that leaves name brand HCG...
  8. Jason Sypolt

    What sugar substitute do you use?

    Glycine works very well. I have a container of packets that can be used to sweeten something. Only thing about Glycine is that it makes some people drowsy.
  9. Jason Sypolt

    Low E2 With No AI

    Talk to your doctor about injecting 3-4 times per week instead of twice and consider a thyroid panel: FT3, FT4, TSH, RT3. This happened to me as my SHBG decreased. if you are taking any other anabolics or have an undiagnosed/untreated thyroid issue then that will cause problems. TRT is not a...
  10. Jason Sypolt

    Are you a web developer with an interest in HRT?

    Please message me if you are an ASP.NET developer in the US who is interested in working on HRT-related projects full time. Skills Needed: ASP.NET Core 2/3 Entity Framework SQL Server/AzureSQL Azure platform Bonus points of you have experience with Syncfusion and/or Power BI.
  11. Jason Sypolt

    Testosterone mixed with MCT oil

    There is no lawfully-made pharmaceutical (USP) testosterone using MCT as a carrier oil. So arguing on the merit of health is a moot point.
  12. Jason Sypolt

    subcutaneous injection into stomach

    There is no hard limit on too much, but the more you inject at a time, the more you need to be aware. Strength (mg/mL): this is only a factor in UGL and not pharmaceutical T and with some injectable nutrients. The higher the concentration, the more likely it is to sting when injecting shallow...
  13. Jason Sypolt

    PT-141 and Trimix?

    This thread was started some time ago and I have seen the 2 being used together more often lately. I personally would not use them together for what I need because it’s just for fun and I don’t want to end up creating a problem by overdoing anything. But like almost everything else here, it...
  14. Jason Sypolt

    Testosterone and hematocrit fluctuations on the same dose and protocol?

    Exactly. as far as T, SHBG, Estradiol, Cholesterol , and many more biomarkers contribute to where serum levels stand. And we aren’t even getting into downstream factors which affect the negative feedback loops which regulate the biomarkers that I mentioned. It’s sort of amazing that anything...
  15. Jason Sypolt

    Acclimation to Thyroid Supplementation

    Are you using pharmaceutical or the liquid stuff? Highly recommend NOT using liquid if that is the case because it is impossible to dose accurately which is essential for thyroid medications. for T3, starting low at 5mcg every am is an easy way to start and then titrate up 5mcg every 10-14 days...
  16. Jason Sypolt

    Testosterone and hematocrit fluctuations on the same dose and protocol?

    Your body is not a machine, and there are many factors that come into play in determining lab results. And unless the testosterone is UGL then the “bad batch” argument is nonsense. In the US, testosterone cypionate, enanthate, and propionate can also vary vial to vial by +/- 10%. That is what...
  17. Jason Sypolt

    Prepare me for My Defy Consult

    There is no set cost. You only pay for what you need for your treatment that is personalized just for you.
  18. Jason Sypolt

    Prepare me for My Defy Consult

    I am both a patient and employee and have had many consults. The best advice I can give is to write down your questions beforehand to ask during the consult. And when you are in between consults, keep some notes somewhere with any concerns and questions to ask. It is surprising easy to forget...
  19. Jason Sypolt

    First blood work after adding Nandrolone

    Nandrolone will make T to appear higher unless you get the more expensive LC/MS test. It will also decrease triglycerides. You could try splitting up the ND into smaller daily injections if you are willing. My HCT crept up to 53, and Defy changed my protocol to inject ND 20mg on each weekday (I...
  20. Jason Sypolt

    Oxandrolone and Nandrolone (common availability)

    Empower has not discontinued Oxandrolone.
  21. Jason Sypolt

    Oxandrolone and Nandrolone (common availability)

    Definitely. And the more the doors open to these medications by those who went first, the more we will see people with the cash but not necessarily the brains or morals starting or expanding “clinics” to make some money. It happened with T and peptides too. There exist many online testosterone...
  22. Jason Sypolt

    Trimix users: can you still have normal erections?

    Yes, Defy will prescribe Phenylephrine upon request or if a patient is unsure/uncomfortable with something new like Tri-mix and concerned about priapism.
  23. Jason Sypolt

    Oxandrolone and Nandrolone (common availability)

    If you have been lifting for 20 years and are already at your peak natural, then you know that you are the exception when it comes to seeing changes from low-dose AAS. Your body and performance is already optimized and has nowhere to go but up by adding anything. I’m not discounting your hard...
  24. Jason Sypolt

    Oxandrolone and Nandrolone (common availability)

    Both Nandrolone and Oxandrolone will lower triglycerides (and HDL to be fair) and will also lower Lp(a). Lp(a) is an excellent predictor of CVD, possibly more so than HDL/LDL. I have genetics for high triglycerides and my dad died from atherosclerosis almost 3 years ago. They were over 400...
  25. Jason Sypolt

    Trimix users: can you still have normal erections?

    You absolutely keep normal erections. What you will probably find however is that you can become psychologically dependent on Tri-mix. By that I mean with the use of Tri-mix, you are good to go, guaranteed. And that is kind of the point. You never have to worry about it again. So then you decide...
  26. Jason Sypolt

    Oxandrolone and Nandrolone (common availability)

    That is really a LOT of trouble that you are going to, for what? Oxandrolone has around 9-11 hour half life. Just take the capsule with some caffeine which will more than double the bioavailability and make things easy on yourself.
  27. Jason Sypolt

    Oxandrolone and Nandrolone (common availability)

    Reading through this thread, some of it is a bit sensationalized to the extent of what it was originally poking fun at. It isn’t Christmas for prescribing anabolics such as Nandrolone, Oxandrolone, even Stanozolol. The fact is that in the United States, they have never been illegal nor more...
  28. Jason Sypolt

    Oxandrolone (Anavar) with TRT

    You will be ok. Glad to hear that you are on the right track. Oxandrolone and Nandrolone will lower your Estradiol as you may have found, but taking Oxandrolone for only a handful of days honestly won’t do much harm (or good). if you are going to self-medicate for now, I strongly encourage you...
  29. Jason Sypolt

    Oxandrolone (Anavar) with TRT

    This forum is here as an educational and harm reduction resource. But I am going to tell you right now that it is not going to be open Q&A for something that you clearly do not understand at all so that you can continue to derail your health taking the parts that you like. Read the sticky posts...
  30. Jason Sypolt

    PT-141 and Trimix?

    You may have missed, which can happen if injecting st the wrong angle or not deeply enough. You want to do the injection about an inch and a half from the base of the shaft. Think of a clock. When looking down, if the top of the shaft is 12 o’clock, your right side is 3 o’clock, and your left...
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