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Thanks, I just did some reading. I have some specific questions I'll PM you about.

Interesting. I would have expected more differences in cyp vs prop just knowing how differently the esters behave and clearance time, etc. What motivated you to move to creams? Are you doing scrotal ones or arms/back? I started my TRT experience many years ago with Androgel. It failed to raise...

Anyone have updates on their tests with Prop? I've been on cyp for 7 years and struggled with water weight the whole time. Finally fed up with it and want to try a trial of a short ester to see how I do. I've been injecting EOD for years so I know I can keep it up and ED wouldn't be that big a...

The big dose wasn't shots, it was an oral dose of D2 @ 50k IU. Anyhow, I'm not as concerned about the IGF-1 elevation being due to acromegaly. I came off my T temporarily (miserable!) and my IGF-1 lowered substantially, so it seems like it's elevated secondary to my TRT. Currently working on...

Thanks for asking. To my great reluctance, I did an experiment where I came off my testosterone for a month to see how my IGF-1 level responded. It came down by about 40-45%, to just above the normal range. My doctor wanted to do some additional GH testing which I haven't yet done, since I had...

Interesting, Mark. I don't have insulin resistance, as my OGTT blood sugar curve looked good. My thyroid looks pitch-perfect as well, so not that either. Time Level 0 Minutes 95 mg/dL 30 Minutes 163 mg/dL 1 Hour 137 mg/dL 2 Hour 87 mg/dL There are case reports of people with...

I just got my MRI report. They only used a 1.5T magnet (vs the higher resolution 3T magnet), but there was no large/apparent tumor of any kind and the pituitary and sella appear normal. So either I have a microadenoma small enough that it couldn't be resolved on a 1.5T magnet, or there's no...

100% agree. I appreciate what you're saying. I approach all this with a spirit of self education. I was startled by Vince's tone and while there may be something lost in text versus voice, Vince's "gotcha" approach really rubbed me the wrong way. I try whenever possible to link to research so we...

Thanks Mark. I think the distinction Vince missed is between a pituitary adenoma and acromegaly. I have no other symptoms of pituitary disease (normal prolactin, expected low FSH/LH being on TRT, etc) and the only abnormal result is the elevated IGF-1. So the labs raise suspicion of a pituitary...

See Vince, I'd be more likely to take you seriously and trust your knowledge if you'd known what an oral glucose tolerance test was. Nothing wrong with not knowing what that test is, but you acted dismissive with your "not some saliva test" comment. No need for your snark, but you brought it...

It's not a saliva test. It's a blood test done over 2 hours with a baseline draw, the ingestion of 75g of glucose, and blood draws every 30 minutes of both blood sugar and GH levels to determine whether the GH level is suppressable. Link to full description here, but you can see that this is...

Just to circle back on this, I got the results of my oral glucose tolerance test today. Completely normal at all time intervals on the test, with a fully-suppressed GH level. So whatever the cause of my elevated IGF-1, it doesn't seem to be a pituitary tumor secreting growth hormone. My body...

Just to circle back on this, I got the results of my oral glucose tolerance test today. Completely normal at all time intervals on the test, with a fully-suppressed GH level. So whatever the cause of my elevated IGF-1, it doesn't seem to be a pituitary tumor secreting growth hormone. My body...

Interesting. You have me very curious. I found the following study that was in women with breast cancer. Looks like a 35% increase in IGF-1 with Aromasin. Granted it was a 2-drug study but after doing some digging, it doesn't seem like Fulvestrant (the other drug in this study) has an impact on...

Can anyone comment on whether there are connections between IGF-1 levels and use of exemestane/Aromasin? I’ve seen conflicting reports on the way that different AIs affect IGF-1, and I’m especially curious if anyone can share both anecdotal and research-based info on how Aromasin may affect...

I got some updated/repeat labs. Curious if anyone here has thoughts. Looks like prolactin is totally normal, IGF-1 still elevated, but IGF-1 Binding Protein is also above range, so it appears my body doesn't have enormous free levels of IGF-1 circulating. Still feeling quite concerned...

Thanks. The question is less about the impact on cancer than on where my levels fall in that U-shaped distribution. Since testosterone can raise IGF-1 levels, what I'm trying to understand is whether my levels are indeed far outside the norm or whether they are elevated-but-not-shockingly-so for...

50,000 IU is standard of care for severe deficiency, which I had on a blood test. This journal article explains.

Thanks. I'm seeing my GP this week and will ask her to retest the IGF-1 level ASAP at a different lab to see if it was an error or a transient high reading. My consult with Dr Saya isn't scheduled yet, so I'll likely have to see a specialist to run this down before then. In terms of effects...

Thanks for the reply and reassurance. Definitely didn't add a zero. It's a 50,000 IU dose taken once a week. The trade name is Ergocal. What stood out to you about that dose of D2? Same concerns if it's weekly vs daily? I appreciate that you said that you don't see cause for concern. Can you...

Background I'm 36. On TRT for six years. 6'2", 215lbs. Have had my GP manage my TRT and have never gotten specialist care to get dialed in. I'm in the process of signing up with Defy Medical to have Dr. Saya manage my TRT. My GP has had me on 50,000 IU per week of Vitamin D2 after I came back...

Hi all. Looking forward to being a member here. I'm 36 and have been on TRT for 6 years. I've never had anyone other than my primary care physician administer T to me. I'm finally getting started with Defy Medical (just had bloodwork this past week) and am looking forward to working with a...