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I’ve been following this thread for a while as I’ve always felt Empower/compounded HCG was weaker than Pregnyl. I never used Empower for HCG mono but I have used Hallandale and Pregnyl for HCG mono so I can compare those. I was using Hallandale and then recently I switched to Pregnyl since it...

Thank you for the comprehensive reply @madman. Part of the reason I ask is I’ve been very interested in Dr. Saya’s fertility rankings posted below (HCG Monotherapy to Clomid Ratio For Fertility): “1. Clomid/SERM treatment 2(A). HCG + HMG (or lyophilized FSH) 2(B). Baseline no treatment (no...

I’ve been very interested in Dr. Saya’s fertility rankings posted below (HCG Monotherapy to Clomid Ratio For Fertility): 1. Clomid/SERM treatment 2(A). HCG + HMG (or lyophilized FSH) 2(B). Baseline no treatment (no HPTA suppression via TRT, AAS, HCG mono, etc) - assuming no significant degree...

@Cataceous You’ve posted that study demonstrating that 1000iu EOD of HCG is the most effective for T production (a great study despite its small sample size so a big thank you for that). Do you know of any studies that analyze the most effective HCG dosing protocol for sperm production?

This and Nelson’s link elucidates the lunacy of frequently using AIs to counter excess high E at excess high levels of T. Rather than reducing T and keeping both within healthy range and in balance with one another, the first gut reaction is too often to keep the T at a likely unhealthy high...

This is a slightly different point but I figured this was a good thread to post it in. Isn’t it interesting that men and clinics always say they want high normal T levels but never say they want high normal E levels (usually wanting low or medium)? This is even among the men and clinics that...

Has anyone here visited Dr. Jed Kaminetsky (Urologist) in NY for HRT/TRT? I am curious to hear people’s thoughts about him.

Not trying to bust your balls or anything. I was just wondering what you thought was a proper guideline range for T/E ratios. 15-20? 15-35? Or in E/T terms, .03-.06? .04-.07? Having read your articles, the .3 benchmark you suggested above seemed out of line with your general views on AI use.

You said “I think 0.25 mg per week of anastrozole makes sense for men whose conversion is above 0.3 percent (I think we should monitor estradiol like we do free T. Free T percent should be 2% of TT or above). DHT should be 10% of TT or above.” An estradiol of 45 pg/ml relative to a TT of 1200...

I don’t understand how this study answers my question. It says to keep the T/E ratio around 12. Your statement above suggests that if one had a ratio of 15-30, that they should take an AI.

@Nelson Vergel do you still believe this? This seems a little bit on the aggressive side for AI use, no? This would suggest that one with a T/E ratio of 20-25 should be using an AI (though .25mg is certainly not a hefty dose).

How could it’s half life be longer—isn’t Xyosted just T Enanthate and that’s it?

So what you’re sort of saying is that since TT=FT + bound FT, it wouldnt make sense that the ester is injecting TT because it can’t inject bound FT into your body, right? Could you still argue that men with low SHBG are more sensitive to Estradiol spikes given their free estradiol?

I think the Xyosted product and it’s studies show how warped peoples conceptions are of normal TRT doses. People think 100mg is low because they compare to the standard 200mg doses by the low grade T clinics. In reality, it’s a high dose and maybe doctors should reconsider it as a starting dose.

It seems like TT should be the X variable and FT should be the Y variable, no? You’re TT would depend on how the ester releases the testosterone, right? How could your FT levels influence how quickly the ester releases the testosterone? Also, your answer seems to imply that higher SHBG men...

It seems like some users don’t buy into the notion that low shbg is cause to inject more often. But the math is relatively simple: take two men: Man A has a FT percentage of 2% and Man B has a FT percentage of 3%. If both take 100mg of T a week, and each has a TT peak of 1000 and trough of 500...