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Orrin, is your picture actually showing 1/2 ml (2 clicks) or 1/4 ml (1 click)? Do you apply 1/2 ml (2 clicks) all at once in the morning, or 1/4 ml (1 click) in the morning and 1/4 ml in the evening? How do you ensure the best possible absorption (application locations/preparation of locations...

Dr. Saya being an active presence in the forums and offering particular, specific and useful advice is what got me to start with Defy. It is unusual and appreciated. Welcome to the way medicine can be done collaboratively. Thank you, Dr. Saya and all the forum members who have so much useful advice.

Has anyone tried either of these personally to increase T cream absorption? I don't think any providers or pharmacies have ever mentioned them.

Somewhere I came across MSM and DMSO being used to increase absorption of testosterone cream. The person using DMSO said he dropped his T cream requirement by 75 percent since the absorption increased so much. It did make me wonder why these have not been discussed before.

Regarding the timing of blood testing in relation to testosterone cream: The Defy lab orders I got yesterday contain this comment: Medications:Please be sure to have your labs drawn BEFORE your next testosteroneinjection or AFTER your hormone cream application that day (unless...

This is a stretch, but any possibility of prior osteoporosis and then TRT remodeling bone in the spine?

Thanks, Nelson. I have had issues with providers that I have intentionally kept off of the forums and resolved directly to help keep the proper focus here. It may be useful at times to ask questions about providers to see if others can provide guidance from their own experience, but those...

I have used MRM brand micronized DHEA with success in raising levels.

Loophole, yes, safe for use, who knows? Many people use research chemicals and consider their sources reliable, but you will see the disclaimers regarding human use on the websites.

It is being sold as a research chemical, not for human use.

Thank you, Dr. Saya. I noticed in another post from several months ago you mentioned a typical starting transdermal T dose of 3-5mg daily and then moving up to a max of 15 mg/day if necessary. Is this still the typical starting point and range? How often do you go back for labs to adjust vs...

My wife is post menopause and uses CombiPatch estradiol/norethindrone at 0.025/0.125mg per day. This is half the intended dosing of the patches, as we cut them in half. However, this seems to work best for eliminating spotting, which was an issue, while actually succeeding in eliminating hot...

59, psa 2.7

Any published studies on Vit D lowering SHBG? I have tried up to 10k units (Vit D level 69), now doing 4k units (Vit D level 58), SHBG is at 55-65. Anything published on how much lower SHBG would go at Vit D levels between 10k and 20k. Thanks.

I think it mainly boils down to this: if a man is interested in sex and his sexual function declines to the point that he cannot reliably perform, then he will eventually go to the doctor because he is "not feeling well." The discussion will begin there, and hopefully his testosterone will be...

Anyone have experience with this?

Beautiful. Thank you for taking the time to educate. These are difficult concepts, but fascinating, and can be grasped if you just take the time to think it through. I really appreciate your willingness to discuss the technical aspects of this. Very, very helpful :)

Dr. Saya, what is the minimum amount of Clomid you have seen that can keep the proper effective stimulation, considering the half-lives of the zuclomiphene and enclomiphene isomers? I have had success at 12.5mg E3D and am now trying 12.5mg 2x/week.

Thanks for your insight, Dr. Saya. One follow up question: Is there any difference in the estrogenic effects themselves being addressed that would lean toward DIM and/or Cal D-G vs. going the anastrozole route? For example, does DIM and/or Cal D-G work better with zuclomiphene-specific issues...

Dr. Saya, what results have you seen when trying to manage estrogenic difficulties of zuclomiphene with low-dose Clomid (example: 12.5mg 2x/wk) via the use of DIM and Calcium D-Glucarate? What doses of each have proven useful in the process?

I use LabCorp as well. I once asked if any of my blood tests were not covered by my insurance, would I pay the "list" price or the UHC "insurance negotiated" price. I was told I would get the UHC pricing. That is significant, as UHC insurance pricing per test is on average about 10 percent of...

Just for a frame of reference, I take 12.5mg clomiphene E3D and it takes my TT from around 337 to 775 last time I had it checked. Free T remains low at around 9 due to high SHBG. No subjective benefits.

The enclomiphene isomer of clomiphene may clear quickly, but the zuclomiphene isomer will take longer. I think full clearance of clomiphene takes around 6 weeks.

12.5mg/day and 25mg EOD are the same thing, given the half life of clomiphene.

Let the lawsuits begin. At least 3 law firms preparing class actions suits against Repros for misleading investors on supposed class B filing with FDA. We just want our easy-to-take pill!! Will it ever come to market?

What will this mean in regard to the scheduled approval process for Androxal? Any delay or denial because of this ruling? More trials required?

Nelson, what do you think this will mean for Androxal approval that was to occur in 2015 after they finished their Phase III trials this year? Repros claims that Androxal is not what the FDA is targeting, since it is supposedly for men who have low T from being overweight. Hmmm, that's who they...

I have tried NOW brand Nettle Root and did not really see any response.

Bass, Chris, others, question on the Vit. D. All my numbers are ok except for Tot T (523) low Free T (8.4) due to high SHBG (55). I currently take 6,000 iu Vit D ED and my level is at 69. If I were to bump up to say 10,000 iu Vit D ED, would that significantly help lower SHBG? Will that cause...

Would like to see FreeT doubled to 15-16 ideally. Why? 57 years old, diagnosed with osteoporosis. Low libido compared to 4 years ago (still had same libido then as in 20s-40s). Low motivation, less emotional by far. Extended refractory period of usually 48 hours instead of 12-24 hours. With...

Will be interesting to see the DHEA-S result from using only Pregnenalone, Paco. Might help us to answer the question of Preg alone, or Preg + DHEA (my current approach), or just DHEA alone for raising DHEA-S labs.