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A new meta-analysis looks at the studies on fat free mass and strength gains from TRT and finds a difference in results depending on how it is administered. Intramuscular injection was 3-5 times more effective than transdermal application in increasing fat free mass (FFM) and strength. When...

How do you guys combat acne... since high school I have had this scalp acne as a result of wearing hats and helmets and now that I have started TRT it seems to have flared up. Luckily the acne I get is hidden by my hair but it truly hurts sometimes. I wash my hair with hibiclens (which I got...

I got curious about the risks of growth hormone after seeing that many anti-aging clinics offer growth hormone or its secretagogues. The best research paper I could find on the subject is this review from 2005 "Does Growth Hormone Cause Cancer?" I don't think it's the last word on the subject...

Table of Contents Thank you very much for commenting guys. I'll try to fill in the blanks:Diabetes I have been diabetic for approx 14 years. 2.5 years ago I fired most of my doctors and took control of my own health. My endo had me on 4 shots of insulin daily plus metformin. My...

I'm sure it's been discussed but in my searches I come up with nada. In the last year I have been doing testasterone and B complex weekly. I have also recently started iron injections. Due to earlier surgery, I lost the ability to absorb iron sufficiently and almost totally depleted my body's...

Table of Contents Hi everyone, I've been reading here for a little over a year and I've found this site most educational. Thank you to Nelson for all the informative material on this website (I also enjoyed your book which I bought on Amazon) and for everyone else here who contributes...

Table of Contents Estradiol is a very important sex hormone--in fact, it's the primary female sex hormone. It plays a central role in female reproductive health, as it promotes the development and maintenance of the ovaries, eggs, and other reproductive tissues. The male body does produce...

I have tried the liquid Cia but for some reason it does not agree with me. My doctor wrote a script for 5mg daily Cialis and I printed a coupon from Lilly and got 30 tabs free. When I need a refill my Doctor will write another script, but I was looking into Canadian Pharmacies or...

As we learn more about how elevated levels of Lp(a) can potentially kill us before anyone can determine the cause, it is imperative that everyone get this lipid marker tested frequently, especially those on any type of HRT regimen. It is entirely possible that one of the leading culprits behind...

Table of Contents To all members: Below is an overview of my history, and TRT cream protocol that I found most effective for myself and others I am a 55-year-old business owner who has always exercised, eat healthy foods, and tried to stay on the path of wellness. For the last ten years or...

Adults with hypothyroidism prescribed levothyroxine were more likely to experience lower health-related quality of life and increased comorbidities when compared with similar adults not prescribed thyroid hormone therapy. “Hypothyroidism is a common endocrine disorder, and substitution...

Current infection with Helicobacter pylori (H. Pylori) was associated with significant subclinical coronary artery stenosis in a population with no prior arterial disease, suggesting a need for earlier diagnosis and treatment of this pathogen to forestall progression to overt disease...

Table of Contents This is an example of just one protocol, since there really is no "one way" to do it. This has proven a very effective foundational protocol for Defy, but of course every patient is different and therefore treatments are individualized as needed. TRT: EndogenousRestoration...

Testosterone propionate is definitely not for everyone, however, there are certain men who do benefit from including the ester in their therapy. Propionate needs to be injected more frequently than cypionate, roughly every 2-3 days if used as a monotherapy to keep serum testosterone stable...

Compounded injectable testosterone medications like cypionate are presently being pushed out of the market. Compounding pharmacies provide a low cost alternative to standard and more expensive manufactured brand name medications. In the case of testosterone, compounding pharmacies are able to...

Safe and Effective Treatment Yes, and Thalidomide was “safe and effective” as treatment for nausea during pregnancy, too. If you don’t know that story, I’m sorry for what you are about to learn when you search it. And progestins (synthetic progesterone) were “safe and effective” for women as...

Table of Contents From the referenced content below which states these factors affect your testosterone levels, I was greatly violating most of them. Is it possible I should have fixed these before starting TRT? i wonder how much of an impact these could really have. How Much can These...

Table of Contents Introduction Currently, only topical minoxidil (MNX) and oral finasteride (FNS) are approved by the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) for the treatment of androgenetic alopecia. Although FNS is efficacious for hair regrowth...

One of the most frequent, unwanted side-effects for men on TRT is the rise in hematocrit levels. A recent study of trans men highlighted the issue. In trans persons on gender-affirming hormonal treatment, a decrease (in trans women) or increase (in trans men) in hematocrit is often...

Table of Contents Pregnenolone - Why You Need It Pregnenolone is a hormone that many Doctors and men are not familiar with or understand its role in the CHOL pathways but it’s critically important to our health as it is a "precursor hormone" to all other hormones in our body. Restoring...

Does getting a good pump in the gym while lifting have anything to do with testosterone levels? I know you need good blood flow to get a pump but I was wondering if having higher testosterone would lead to greater pumps in the gym. The muscle pump is related to various factors such as- rep...

Earlier this week, Senators Orrin Hatch (R-UT) and Sheldon Whitehouse (D-RI) introduced the SARMs Control Act of 2018. If passed and signed by the President, the Act would amend the Controlled Substances Act to list SARMs as Schedule III controlled substances, meaning they would be regulated by...

Getting answers, you have done excellent troubleshooting by trying both Testosterone Cypionate and Testosterone Enanthate to narrow down why you are having a local reaction to these medications. You are also correct that it's impossible to create a "jet" of oil with a syringe due to the fact...

This paper is from 2010, but I'd like to draw attention to it as steady-state has been emphasized in threads about HRT. Reference Here are some things covered in this study: Steady state of tadalafil is reached after 5 days. This is probably why the Cialis website notes 4-5 days as...

Table of Contents By Nick Gold Erectile dysfunction (also known more commonly as impotence or sexual dysfunction) is the inability to maintain a sufficiently rigid erection for a satisfying sexual experience. According to the Global Survey of Sexual Attitudes and Behaviors, erectile...

The questions are regularly posed here at Excelmale: Will HCG help me maintain fertility while on a TRT protocol? How much HCG must I use to remain fertile? This Case Report Answers Some of Those Questions A 40 year old man presented to an endocrine department in August 2015 with a 4-year...

It's a mouse study - the point is acknowledged. However, new research at MIT raises some intriguing issues. As people age, their intestinal stem cells begin to lose their ability to regenerate. These stem cells are the source for all new intestinal cells, so this decline can make it more...

Table of Contents It's been known for years that PDE5 inhibitors, Viagra, Cialis, Levitra, improve erectile function in men. However, a surprising number of men in a double-blind, controlled study of sildenafil (Viagra) responded well - better than expected - to placebo as opposed to the...

Table of Contents Estradiol is the most important female sex hormone and it plays a significant role in developing female secondary sexual characteristics. It also plays a vital role in maintaining proper bone density, regulating body fat, and ensuring a strong erection in men. This type of...

Table of Contents It's a well-known fact: excess body weight can be seriously dangerous for your health! Being obese or overweight can take a toll on literally EVERY one of your internal organs and functions. It can increase your risk of psychological disorders, speed up cerebral...

Table of Contents As the years slip slowly by, our bodies begin to decline. It's an unfortunate truth, but the good news is that we can DO something about it. Hormone supplements can help to restore our vitality, boost our sex drive, enhance cognitive function, increase muscle mass, and...