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Thank you Nelson. Very informative. I will try it.

Hi Nelson. Do you have any links that I can look at on this? From what I have seen in the internet the recommendation is a GHRP with a GHRH.

Thank you. I am just curious, if you could share, what is the rationale that they gave you for such a high dosage of sermorelin? Are you sure it is 1000 mcgs? That stack based on Defy's prices is more than $400 per month. Is that correct? The reason I ask you is that I want to switch to that...

hi. Any update on this combo?

Hello. I just posted a similar question to yours? I want to switch to that combo. Is this from Defy? Are you planning in having two injections or putting the two dosages in one and injecting? That seems like a high dosage but I am just getting familiar with this combo so don't take my word for...

Is anybody in this forum taking this combo? I have been taking the GHRP-2/Sermorelin combo from Defy for about six months with pretty good results. IGF-1 increased from 100 to 200 and has remained as such. I have lowered my body fat to 15% from 25% and increased lean muscle significantly (dexa...

Thank you Nelson. I am glad I did not start taking Metformin. Very informative.

So I guess the conclusion is that is better to test if one wants to know the free E. I will do the free E2 test next week from labcorp and post the results here.

Dr. Crisler thank you for responding. So if I am taking 500 IUs twice a week, should I then divide 1000IUs in 7 days and take daily or should I adjust the dosage lower based on daily injections? Thank you in advance for the guidance. I should have asked you this when we had our advisory call.

I only see one free estradiol test in the labcorp test menu: 500649

hi Gman86. Why do you have such fluctuations on your E2 levels? Is this based on different AI dosages? On what of all these ranges did you feel best?

Hi. Just curious on why you inject HCG daily ? I am also under Dr. Crisler's care and he has me on 500 IUs twice a week. What is the rationale to switch to a daily injection?

wow. I might be one of "those guys" who have not learned just yet. I have SHBG of 53 and E2 (sensitive) of 39. I take 0.125mg anastrozole twice a week. I almost increased my AI dosage to 0.250 mg thinking that my AI was a bit high. I am glad I did not. I will go ahead and test my free E2. I...

My head is spinning with all this. I am all for testing free estradiol instead of calculating it and I will test it next time, but what is the "good range" that free estradiol should be at then?

Did you increase your T dosage frequency? I have similar parameters than you. Except for E2 which is now at 39 (sensitive). I felt best when it was in the 25 to 30 range. My E2 increased after I reduced my AI from 0.5 to 0.125 ( after switching from a local clinic to Defy). I want to lower my...

Dr Crisler, do you recommend more frequent injections regardless of the SHBG? In my case I am injecting Dr Crisler if I understand correctly you recommend increasing dosing frequency as a way to control elevated estrogen symptoms. Would this apply for guys with high SHBG too? My SHBG is 53 and...

I can download it but it does not open for some reason.

Thank you for the feedback. I will look into it.

Yes, that is the paper I was looking for. Thabk you Vince.

I am pretty sure balancing B12 would be the easiest thus the least of my concerns. A supplement or subcu injections would balance B12 easely. The challenge is the unkown impact on hormones I believe.

Yes, thank you. I plan to check my B12 levels often and supplement accordingly. However my main concern is the impact on sex drive. I have seen conflicting information on this. It seems that it does lower testosterone. By how much, I really don't know. I don't want to screw up markers now that I...

Thanks Vince. I plan to start with 250mg a day and see what happens. So in your case you did not see an increase on your SHBG, drop on your free T? Any impact on your sex drive ( I read somewhere in the internet about that too)? Thanks again.

humm. Ok. Thanks Vince. I assume that it does not increase SHBG in my case but the only way to be sure is to try it I guess.

I have been doing some reading on Metformin and also in Jay Campell's book where he supports the use of metformin for anti aging purposes. I also watched the Nelson's video with Jay. There is a thread in this forum that also that talks about metformin and its relationship with SHBG and...

We are talking about spliting a troche in more or lesss equal parts. It will not be 100% accurate.

Hey. I just ordered the troches last week from Hallandale. I will let you know as soon as I get them. I might want to start that low too if I can split them that small.

Sorry, Defy does not offer a 5 mg troche. They offer 25 mgs and I plan to split it in four so I guess is a 6.25 mgs. That is what I will use to start.

I am going to start with 5 mg troche from Defy and see what happens. Not sure why this doc is recommending 25mg twice a day. Doesn’t seem like a responsible thing to recommend.

I saw the video by the way. Very informative and pretty well supported. Thank you. It says that DHEA converts to estrogen and that one should take max 15mg a day divided in doses. Interesting how many different POVs there are on this one subject. wow.

That is what I will do. Start with 5 mg once a day instead of going to 25 mg twice a day as this doc suggests. One thing I have learned is that even expert T doctors are still learning about this stuff.