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I assume it'd be best at trough so it is comparable to when T is tested. I just bought the free test E test and will test in a couple of weeks or so. In talking to my Defy doc however, I asked him and he was puzzled I was going to do that test. He said that there are not known good ranges for...

Vince just curious as you have mentioned this a couple of times. You mean to say that some people feel better when SHBG and E2 are similar as a number? That would be a good reference to have.

I assume you meant to say mg/ml so if the vial has 250 mg/ml, 0.25 ml is 62.5 mgs as fifty is saying.

Thanks guys for the feedback. My goal is to eliminate AIs. All my bloodwork is good so my thinking is to up the frequency then test, if I see my E2 a bit lower and all the other markers look good, I’ll eliminate AIs so the net effect on E2 is marginal.

Great input. Thank you. My main goal is to eliminate arimadex without increasing my e2 . All my blood markers are great. I assumed based on what I have learned here that by increasing injection frequency, E2 will go down so if I eliminate AIs then the net effect will be little change. I just...

I assume

Also, aren’t we supposed to lower the total weekly dosage if we move to a higher injection frequency? How do you find that number? For example I inject 148 mgs a week twice a week. How do I estimate the total weekly dosage if I want to move to EOD or even daily.

So for those of you who have switched to EOD, have you noticed any benefits? any noticable changes in your bloodwork? Also anybody injecting EOD with a higher SHBG meaning > 50 or so?

Thank you! I noticed they habe lipotropic injections too (lipo-c). Defy has then too. That’s a great fat burner as well and pretty afordable. I have used lipo-c with good success too.

Good find. It looks like a good deal. Better than the local Clinic I was looking at here in Fort Lauderdale. Do you know the process to get buy it?

I like your approach joe. Maybe a better approach to eliminating AIs completly would be to extend the time of usage and monitor. So for example, instead of taking 1 dose of anstrazole say 0.125 mgs twice a week, take one once a week, monitor for 8 to 10 weeks. then take one every 10 days...

Sorry last sentence meant to say: maybe this happens to men whow have low SHBG to start with.

Actually the complete opposite happened to me. My baseline T was 400 and my SHBG was 82. 8 months later my T is 1230 and my SHBG is 53. I never saw an increase of SHBG with higher testosterone. Maybe this happens to me who have low SHBG to start with?

Dr. John: Like most of us here when we post, it'd be helpful if you could post your protocol before and after stopping AIs and your main blood markers. It'd be great to see that.

Thank you guys. Mine has come down from 82 injecting once a week to 75 and then 53 injecting twice a week. I'd like to move to M-W-F protocol. I was injecting 160 mgs once a week and moved to 74 mgs twice a week. I need to decide the dosage if I inject 3 times a week. Probably 45mgs or so three...

I searched the forums but could not find the answer. For those of you who have increased injection frequency, have you seen an increase in SGBH? Does changing injection frequency have any impact on SHBG? Thanks

Thanks for the response. I assume you are injecting subcu daily? I am injecting twice a week and want to move to 3 times a week, I assume I'd need to reduce the total dosage?

Vince: Maybe you posted this elsewhere. but how often do you inject T? I inject twice a week and might want to increase my frequency to better manage my estrogen. I have a similar SHBG as yours.

Hi. I am not sure if I know enough about this to give advice like that. I know that Igf-1 will increase pretty quick at least that was my case. Body composition will take longer. If I were you I’d go with the Ipamorelin monotherapy as Nelson suggests and monitor bloods in 6 weeks for Igf-1 and...

That is exactly what I will do. Enough of this Estradiol control paranoia and blaming Estradiol for everything. As you can see from that presentation and other sources the "20 to 30" range for "ideal" Estradiol is not based on science or any study.

CJC 1295 is similar to Sermorelin but it is improved. Both have 29 amino acids. CJC 1295 is referred as modifed GRF (1-29). Modified GRF (1-29) is changed as compared to Sermorelin in that it has four substituted aminos in its chain that serve the purposes of preventing degradation and oxidation...

Most people blame high E2 for many things without really knowning was is causing the problem, including erections. As Nelson noted there is not a single study linking higb E2 to poor erections.

I got my call with my Defy doc today. We discussed peptides. One thing that caught my attention was his remarks that these peptides might increase glucose. That I did not know. I was wondering on why my fasting blood glucose has gone up to the mid 90s despite my very strict low carb diet and BG...

I thought it was very informative and well documented. I really liked the presentation and I believe everyone in this forum should look at it.

so they did confirm 1000 mcg of Sermorelin? That is a lot. I don’t inject that much sermorelin when I inject the GHRP-2/Sermorelin blend. That stack they are recommending will run more then $400 per month! right? Something doesn’t match. I am having my appointment with Defy tomorrow and will ask.

There are a number of other reputable compounding pharmacies that I know that also sell this compound. Tailor Compounding out of Kentucky and Wells Pharmacy out of Ocala, FL. Let me know if you could get a prescription from Defy.

That is why you need get it through a clinic. Usually they'd charge you between $280 to $330 or so for a month supply of Ipamorelin CJC1295 combo or 20 doses at 400 mcg which would includes consultation and such. Or get the mono therapy from Defy. Or maybe Defy would give you the prescription...

Sermorelin 1000 mcgs seems like a lot for a daily dosage. I am moving away from Sermorelin by way as there are much better peptides available in my opinion. I will use Ipamorelin monotherapy as Nelson suggests or go back to CJC-1295/Ipamorelin combo. Too back Defy does not sell this combo. I...

Yes, my IGF-1 was 100 in January 2018 and it is now 200. It has stayed at 200 since I'd say June 2018 after I used the CJC-1295/Ipamorelin combo. Once I moved to Defy and I switched to GHPR-2/Sermorelin it has not moved that much but that is a good number for me anyway I believe. The benefits...

Sorry I meant to say: I have seen dosges of 300 to 350 mgms per day not per week.

I have seen 300 - 350 mcgs per week for Ipamorelin. For a couple of months early last year I was with a local clinic before switching to Defy and I was put on CJC 1295 with Ipamorelin 5 days on and 2 days off, 400 mcg and I did feel great. This is the formula that Dr. William Seeds who is one of...