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Clomiphene can elevate SHBG which means a lower percentage of free T. As to what your doc said about the estradiol testing, if he said the test was meaningless I think he definitely overstated it. But the test does seem to require an asterisk beside it. The estrogen agonist part of clomiphene...

So I think that calculator there is what is being referenced in madman's original post "...therefore, algorithms for calculating free testosterone concentrations from total testosterone, SHBG and albumin concentrations using the law-of-mass-action equations have been used widely" and are...

Good point, they hand out SSRIs like candy

I told you I'm impatient and I lack willpower! lol I've already waited months and spent a whole lot of money just to get to this point and I haven't even started on any kind of treatment yet. If I go back to the drawing board on the thyroid question now, that's more money for more tests and...

So I gather that you should try to change only one variable at a time in the mix, and give it some time to see results, ideally. This I'm sure is easier said than done as it requires patience and also can involve things like finances, scheduling consultations, shipping of meds/supplements, etc...

To update this in case anyone is interested, they want me to try clomiphene at first because of my age. So I said ok, let's give it a try. Hopefully it will work well for me in releiving low-T symptoms and I won't have any of the vision problems that I've heard about. At some point down the road...

I'm not 100% sure on Dr. Chrisler

I saw an interview with Dr. Rand McClain and he mentioned a "prophylactic" use of anastrozole... I also think I've heard Dr. Chrisler mention this in an interview... If a guy is starting TRT and has a high body fat percentage (say over 20%), they may start him on an AI right from the beginning...

Lol yeah easy peasy.

There is an androgen receptor immunohistochemistry stain test that is somewhat commonly done, but this uses tissue and is usually collected from patients with cancer or suspected of having cancer.

No worries... yeah well if I get my free T into a good range I'll let you know how I feel :)

Yeah I have a similar issue. My lab numbers: 297 ng/dL total and 8.3 pg/mL free... if you convert to get the same units so they cancel out, that puts my free/total testosterone as measured by LabCorp at 0.28% But if I use that link to do a calculation based on albumin, SHBG and total...

I think he was asking if you had your SHBG tested, and I do see it up there so maybe he missed it. You're at the low end of the range there and people say that guys with low SHBG need more frequent injections. Maybe you could try moving to shots every other day... something to think about.

Hey man. So have you gotten the Estradiol Sensitive test? I don't see any E2 numbers. And with a dosage that high of clomiphene it's probably going to skyrocket your E2. A low starting dose is 12.5mg EOD, or 25mg EOD, I don't think anybody does 50mg ED anymore, and even 25mg ED is on the higher...

Do a web search "PSA controversy" and you will get a ton of hits. This is not tin-foil hat stuff either, there is serious disagreement within the medical mainstream about the value of PSA testing. In short, lot of false positives, leading to lots of unnecessary worry and existential dread...

You say you never had any HPTA issues, so why have you been on test for a year? Kind of a mild cycle for gym benefits I guess? That's not really what TRT is about, and that dosage you've been taking is pretty high for TRT. Anyhow you may not have had issues when you started but after a year of...

Yeah interesting so do you find though that you have more energy during the day even if you're not sleeping more at night? Ups and downs eh, well honestly I welcome it because I've been living in such a flat-line state. I'm sort of expecting they'll want me to start on clomiphene because of my...

Ah good so maybe the lab didn't mess up my test after all lol

I like your thinking. Would even be interesting to see some data on what were some typical T numbers even say before WWII or of the typical army recruit in 1940 or something, early part of the 20th century, although I doubt there is much to be found... whatever it was we know it had to be higher...

Will discuss with Defy yep, thanks. But from what I've read I don't think that is the issue for me... I sleep on my stomach and apparently sleep apnea affects back sleepers more, due to the tongue falling to the back of the throat and closing off the airway. Also I feel like my quality of sleep...

I'm in a similar boat to you in that I'm new to this and probably going to start treatment soon. One other thing to consider is HCG. From what I've read, your urologist is probably not going to script HCG and I'm not sure whether those low-T centers do or not. And also from what I've read, I do...

Nice. Never heard of that dosing, do you get your meds through a compounding pharmacy? Any estradiol issues or other side effects?

Hey Nate. Little tip to consider, if you're going to LabCorp on a Saturday you need to make an appointment or else don't bother going, at least around me. My first attempt was on a Saturday but I had no appointment and they were slammed, so I had to push the testing back til the following week.

I don't get good sleep. I've always thought it was insomnia due to anxiety.

So these are my pre-treatment labs... never been on any kind of hormone therapy before or steroid cycles or anything. Age 39. WBC 6.3 x10E3/uL (3.4 – 10.8) RBC 4.94 x10E6/uL (4.14 – 5.80) Hemoglobin 15.3 g/dL...

Yes, way too many false positives and over-treatment, unneccessary procedures... In fact before I got to considering HRT I had decided against ever getting a PSA test. However it seems I will have to get them regularly if I do get on hormone treatment. Age 39, PSA 1.1.

So if fertility is your main concern right now... you went on Clomid for 2.5 mos then off of it for 2.5 mos to see if you had a successful restart. Then you got blood work done, but did you get a semen analysis done at this point? I'm no expert but from what I've been reading, you can't just...

Hey man, I'm about the same age as you and about to start this thing as well. From what I have read, you don't cycle on and off with TRT, cycles are for bodybuilders using supraphysiological levels.

Yep that is a good thread. He's sort of coming at it from the opposite side of things from my situation, but who knows, maybe the lab messed up my test. Future testing will shed more light. Thanks.

One less variable you have to take into account then eh... well I feel pretty confident I can manage it especially since I'm paying attention to it from the very beginning even before starting any kind of treatment.

Yeah it is complicated lol. Weird thing is my FSH was low too. All this stuff is complex but interesting and important I think. Nope not close to TX thanks though.