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I am at the University of Arizona's DNP program for family nurse practitioner. I want to specialize in HRT.

I thought low E2 made your more vascular and shed water? You say you're not vascular anymore and you are holding water right? Bodybuilders crash their E2 to look dry and vascular during contest. // I think my only hope is coadministration of DMNT and HDAC inhibitors// Interesting, i'd be...

//I will absolutely not take pure estradiol because anything that raises my estrogen or that interacts with my estrogen receptors makes me permanently worse. // If you already believe you have no estrogen sensitivity, how could it be worse? that is implying you have some still. I'd be...

If you can get the anxiety down, other symptoms will improve. You can 100% figure out if you have this by working with an endo and taking large amounts of estrogen and see if it produces the negative effects on the male body. You can be the first person in medical literature that this happened...

But theoretically, E2 would pool and increase with each shot because it is not being absorbed by the receptor, that is why the congenital estrogen insufficiency patients all had very high E2. Also, estrogen increases SHBG, so if estrogen is not working on the cells you would see very low SHBG...

I found a few cases of estrogen insensitivity issues, but none of them were involving arimidex use as it is congenital disease. With the MASSIVE amounts of women and bodybuilders using arimidex, there are no cases of this happening. https://en.wikipedia.org/wiki/Estrogen_insensitivity_syndrome...

We have something better in humans , women on Arimidex for years for breast cancer therapy , years of suppression, not months. A finding like this in humans would be a breakthrough .

Yep, I've read a similar study. These dudes were seriously suppressed, 7mg a week is a female breast cancer dose, and women take that dose for years potentially.

That's true, but wouldn't there be reports of women who are insensitive to estrogen after using mega doses of Arimidex for years? Low E2 with women has very similar side effects as with men, there would be robust data and reports from women about this. "from guys asking me what did I do to...

I’m gonna PM you nurselyfe

When I crashed my E2? All my tests have been sensitive, I was at 5 at the lowest in August, a month later I was at 9, a month later I was at 26 and my latest one I was at 21. Are you theorizing you need to be at zero for a while in order for this to happen? My current symptoms are anxiety and...

When I crashed my E2? All my tests have been sensitive, I was at 5 at the lowest in August, a month later I was at 9, a month later I was at 26 and my latest one I was at 21. My current symptoms are anxiety and joint popping, libido is good, erections are good when I'm not anxious, but I...

A 50-60% reduction in mens E2 would be a significant crash as males have lower amounts of E2 compared to women. Say a man's sensitive E2 was 18, he's now around 9 for a substantial amount of time. I will try to find the study but I remember reading it and these men were on 1mg/day for a...

I believe I read one of those studies, males were treated with 1mg of Arimidex per day for months and there were no adverse events reported. That is a hefty dose, I crashed my E2 at 1.25mg a week to 5 and it didn't come back up to therapeutic ranges until a few months later. I couldn't imagine...