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It's noteworthy that 50mg might not be a large dose. I'm aware that P5P is not the same as B6, but here you see them take 400-600mg daily of B6: Pyridoxal Phosphate Inhibits Pituitary Cell Proliferation And Hormone Secretion (PDF) The Role of Vitamin B6 in Reducing Serum Prolactin in Comparison...

Ahh okay. And how do you dose your progesterone? I must be messing up the conversion because I sat at 0.8 ng/ml if the converter works. The reference range also seems wrong, even though I'm aware that it varies between labs.

I have one pre-TRT test where the ref range was 0.9 - 6.6 (nmol/L) and I came in at 2.6. Impossible to say where it's at now, maybe suppressed from the TRT as you say. This was early morning too, so presumably peak (without having read about it). You prefer progesterone supplementation over...

Thanks that's encouraging to hear. I find this study to be of interest: 5-HTP efficacy and contraindications You can see that they have an extraordinary variance in the dosing of 5-HTP and L-Tyrosine, with emphasis on there being a proper balance. This might be very hard to figure out without...

Right, I know of the issue.. if you read some of the literature on it they suggest that you never supplement 5-HTP without Tyrosine as it will deplete your dopamine & norepinephrine. I need to boost my mood / get rid of irritability, I was hoping 5-HTP would help there and that L-Tyrosine would...

@Cataceous Have you considered L-Tyrosine (dopamine precursor) for PRL? Been considering L-Tyrosine + 5-HTP lately (5-HTP of course aggrevating PRL issues but I'm thinking about mental health as well).

I've recently ditched the 18g drawing needle for a 27g (same as I inject with). I'm finding that half the time when I stick the needle in the cyp bottle and pull down on the plunger, I get no test/oil. I generally start by drawing 0.2ml of air into the syringe which I inject into the cyp...

Have you tried any of this? HDL cholesterol: 9 ways to increase it Seems like a shame to quit if you could improve this.

Why did you quit? Was it the HDL?

Very valid point. It's quite disconcerting to feel emotional to the point of crying on a daily basis when you're used to pretty much never feeling that. But I do need to let this settle as you say.. I'm still so curious as to what it is exactly that makes me feel this way. Maybe it's the...

Good point, I think we need to appreciate that people are different. What is your protocol these days and where does that land your E2?

Interesting connection to prolactin levels as well: Patients with primary hypothyroidism presenting as prolactinomas - PubMed

Monday/Wednesday/Friday is common somehow. But out of curiosity, why not just go every other day? (Only marginally more often than 3x per week..)

Alright, I'll buy that, and my interest is piqued. My morning wood goes from zero to granite hard with a hefty dose of anastrozole. E2 stimulates prolactin secretion.

Are you using B6 or P5P? And which brand out of curiosity? And have you had a test while on it?

Maybe of interest @Cataceous @Vince @readalot @madman @Nelson Vergel

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246784/ "Patients with thyroid disorders are more prone to develop depressive symptoms and conversely depression may be accompanied by various subtle thyroid abnormalities. Traditionally, the most commonly documented abnormalities are elevated T4...

Huh, interesting. That's my first experience as well and it was awful. :) He says it might be sensitivity to E2..

Hopefully this is the case. But I can't be feeling like this for months, I feel like I need to address this if possible.

So testosterone seems to have done wonders for my fatigue which I'm really grateful for. However I often feel extremely emotional and almost on the verge of crying. Sometimes after working out, sometimes after sex, often after nothing at all. Has anybody got experience with anything similar...

And a bonus question, do you guys know how long I should try something like this before deciding whether it's working or not? Is it a cumulative thing like with TRT? @Cataceous @Vince

Do you get agitated/irritable with too much? And does it impact your mood in any other way? Tbh I'm mostly thinking about brain fog. But at points these days, with TRT, I get emotional until I'm on the verge of crying out of nowhere. Sometimes after sex, sometimes exercise, sometimes it's like...

I could be using Nebido (Testosterone undecanoate). This is a much longer ester. It shouldn't cure testosterone deficiency.

@Vince @Cataceous Given that rT3 is high-ish or T3 somewhat low (albeit fluctuating). How much T3 is reasonable to take without inducing much suppression? Say you have a 25mcg tablet, cutting it to 10mcg seems like a bit of a pain, but is 10mcg reasonable?

I realise you're not asking me, but E2 stimulates prolactin secretion. So you can lower your E2, either by lowering your testosterone, or adding an AI. Otherwise I don't know of anything other than the dopamine antagonists.

How did you guys decide to get tested and what is it mainly that the thyroid meds are doing for you? Heat tolerance, mood, less brain fog?

No I don't think I've had that. I also wonder if they measure reverse T3 at all in my country. If reverse T3 is high, would you benefit from T3 supplementation? I have had a few autoimmune markers measured as elevated but nothing definite. What fits for me is fatigue, feeling horrible, dry...

I'm wondering if my brain fog has to do with thyroid hormones. It seems to get a lot worse on days I don't take anastrozole. Testosterone promotes conversion of T4 to T3, and estradiol does the opposite. Inflammation also suppresses this conversion. So my thyroid levels over time have been...

I'm sorry to hear. Do you think the responsibility for the breakup rests mostly on your shoulders? Personally lately with cyp and controlled E2 I am feeling more at ease, less emotional. When I'm emotional I get angry and confrontational a lot easier. I've had those problems with TRT as well. I...

Has anybody noticed this? In general I'm seeing 0.8 - 1.3 events per hour (with CPAP) and then on the third night after no AI it reliably creeps up to 2.2 - 2.4.

I think this has been shown in some studies, f.ex.: Fathers' decline in testosterone and synchrony with partner testosterone during pregnancy predicts greater postpartum relationship investment Are you on TRT? I personally feel like you should be able to estimate yourself how much empathy you...