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A preprint of a new study identifies age (>= 65) and obesity (BMI > 40) the biggest risk factors observed in admissions in New York City. The abstract says: "We conducted a cross-sectional analysis of all patients with laboratory-confirmed Covid-19 treated at a single academic health system in...

Examining records of cardiac surgery at the Cleveland Clinic found no increased incidence of cardiac events after the surgery for men on testosterone therapy. The summary says: "Among 20,604 patients who met inclusion and exclusion criteria, 301 patients who used testosterone routinely within 1...

This study of castrated mice shows that loss of testosterone decreases neutrophil activity and increases risk of melanoma. Injecting the mice with testosterone pellets removed the risk. The full text of the article is available online. "Here, we show that in castrated male mice, neutrophil...

I didn't see that this study of hydrochloriquine was mentioned. If it has, my apologies "This study aims to evaluate the efficacy of hydroxychloroquine (HCQ) in the treatment of patients with COVID-19. Main methods: From February 4 to February 28, 2020, 62 patients suffering from COVID-19 were...

Worth quoting the whole abstract: Men’s Health is a urological subspecialty that is at the forefront of innovation, but little data exist evaluating the attitudes that andrologists have toward the current treatment modalities available for managing Men’s Health conditions. A survey of 37...

There's an article in SCMP about this study: Though still preliminary and not peer reviewed, the study is the first clinical observation of the potential impact of Covid-19, the disease caused by the coronavirus, on the male reproductive system, especially among younger groups.

I don't know and have doubts that the question has ever been studied. Before Covid-19 I had not heard of the ACE2 receptor and I don't understand why some tissues express it more than others. Orgasm, of course, is a function of blood flow, so perhaps that is the connection.

This preprint explores the effects of Covid-19 on sexual hormone levels in men. The study finds that LH levels are elevated, FSH and testosterone levels are the same. And they hypothesize that Covid-19 impairs testosterone production, so the body boosts LH levels to compensate, bringing...

It looks like the US Military is still considering giving testosterone shots to Special Operations Forces. I have mixed feeling about this. The article is in the Journal of Special Operations Medicine, the abstract is from PubMed. The conclusion states: "Special Operations Forces training...

Since I'm 65, fertility is not an issue for me. So I think I'll pass.

The biochemistry is over my head, but this rat study showed that testosterone production can be increased by stimulating the production of a "cholesterol-binding translocator protein (TSPO)." The compound used was FGIN-1-27. The abstract says: "Both exogenous T and FGIN-1-27 increased serum T...

A study of men with hypersexual disorder finds that they have higher luteinizing hormone (LH), but not higher testosterone levels. Interesting becuase it shows a connection between LH and libido. The full text of the article is available. "LH plasma levels were significantly higher in patients...

The most likely reason the death rate for men is higher is that in China women rarely smoke, but men often do and smoking obviously is going to worsen your chances with any lung disease.

This is a review article on what we know about the biochemistry of testosterone and growth hormone as they affect muscle growth. It starts: "Hormones are largely responsible for the integrated communication of several physiological systems responsible for modulating cellular growth and...

I saw this article in the news. The link below is to Vault's web site. Vault, an at-home healthcare practice specializing in men’s medicine has announced the raise of $30 million in funding from Tiger Capital Group, Declaration Capital and Redesign Health to reach more potential patients and...

Whenever I see I u-shaped result, I'm a little suspicious. I'd like to see this study replicated.

The occurence of fractures in an elderly population is a significant concern, so this study looked at the relation between the number of fractures and hormone levels, including testosterone. It found fractures were higher at both low and high levels of endogenous testosterone: "Analysis of...

If you've watched the documentary "The Widowmaker," you know the calcium artery score is a marker for risk of heart attack. A recent study, reported at an AIDS conference but not yet published, found more coronary artery calcium progression among HIV+ men on TRT than those who were not on TRT. A...

More evidence that TRT is safe for men after surgery for prostate cancer in this study: "850 patients underwent radical prostatectomy by a single surgeon. All patients had preoperative testosterone and sex hormone binding globulin levels drawn; free testosterone was calculated prospectively.152...

A doctor reports on a case series where finasteride increased suice risk. It seems that it sometimes makes some men feel so miserable that they consider suicide. The abstract says: An important pattern of symptoms was common among all cases who committed suicide in the setting of finasteride...

I saw this tweet on Twitter from Doctor Jonathan Clavell. Hope men here find it inspirational. 81 yo: doc, this #Testosterone I've been taking for a year is great Me: how so? Pt: my mind is sharper, losing fat, muscles are stronger. Even my doc told my diabetes and cholesterol are better Me...

Clarus, the pharmaceutical company that makes Jatenzo, a recently introduced oral formulation of testosterone, has been sued by Lipocine, the company that makes Tlando, a rival oral formulation candidate, for patent violations. Tlando has been denied approval for sale three times by the FDA, but...

Ergo-Log has a more complete write up of this study, including graphs. They also point out that the study was funded by Bayer, maker of Nebido.

To keep the math simple, assume that you take a dose of testosterone on its half life day. That is if the half life is 7 days, then you take a dose every 7 days. Then the amount of testosterone in your system is 1 dose after 1st dose. 1 + .5 = 1.5 after 2nd dose 1 + .5 * 1.5 = 1.75 after 3rd...

Another study looked at American dietary habits to try to determine their effect on testosterone deficiency. The study found two significant factors: Vitamin A, which I have not seen in previous studies, and the combination of protein, fat, and phosphorus, which sounds to me like a proxy for...

Another study shows testosterone levels have declined. Unfortunately, the abstract does not say the amount of the decline. Also note that the study says 20% of young men have low testosterone. Here is the complete abstract: "Testosterone deficiency has a prevalence of 20% among adolescent and...

The owner of Men's Health of Smithtown, New York (link is to the web page) was cutting corners when it comes to treating its clients and prescribing testosterone himself instead of letting a doctor do the prescription. A news report says: "Brian Michael Kaufman, 45, of Smithtown, is charged...

I saw it for sale in a pharmacy in Columbia from Bayer as a 4ml ampule. It's in a castor oil carrier. It seems to be the most commonly available form of testosterone there in pharmacies.

Testosterone undeconoate is commonly used this way in Great Britain for patients who don't wish to self-inject or when the doctor doesn't trust the patient to self-inject.

The is the longest term study of testosterone therapy (TTh) I've seen. The full text of the study is available online. The summary says: "Our findings demonstrate that in subpopulations of men in different weight categories at baseline, long-term TTh produced significant weight loss while...

A summary article from The Journal of Sexual Medicine: The role of testosterone (T) replacement therapy (TRT) in men is still conflicting. In particular, safety concerns and cardiovascular (CV) risk related to TRT have not been completely clarified yet. Similarly, the clear beneficial effects...