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Men with Klinefelter's syndrome usually start testosterone replacement therapy (TRT) in early adolescence and take it life long. Likelihood of DVT-PE in Klinefelter's is 20 times that of the normal population, or about 1 in 50 men. We have new data that most men with Klinefelter's who develop...

Epidemiologic studies of VTE in TRT users and non users So far, epidemiologic studies of TRT users vs non users have not shown a statistically significant increase in VTE in users. Other studies are underway, particularly in Klinefelter's patients. Ultimately, we need a controlled clinical...

We have published two new original data manuscripts which focus on deep venous thrombosis-pulmonary emboli-osteonecrosis which occur when testosterone is given to men or women with previously undiagnosed thrombophilia. We have provided new data which shows that when testosterone is continued in...