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Agreed. Risk versus reward is something we all must determine for ourselves. Most men tinkering with their hormones would agree to a slightly higher risk profile for feeling well versus lower risk and feeling unwell. Risk and well being do not necessarily have an inverse relationship, however...

Welcome to the real world.

Pray tell.

What you are seeking is a precise and predictable answer, for which there is none. Genetic variations is a catch all phrase for responses to medications because it aptly explains at a high level why people respond differently; there is no alternative explanation that is more encompassing and...

Your point is understood. Subjective response is, however, one of the more important variables in the context of TRT. Quantifiable measurements do not tell us how we feel. What good does it do a person to have perfect labs yet feel unwell?

You account for them the same as you would any drug. Varying levels of drug tolerance will produce groupings of responses to the drug. There is a group of men that respond very well to very high levels (way over the range) of testosterone. There are men do well with moderately high levels...

When my levels are too high my mental and physical energy suffers, libido decreases, muscles grow, stomach protrudes, cognition decreases, and my mood is unstable. There are plenty of guys like me, yet there are plenty of men that do well jacking their TT and FT through the roof.

Proviron for androgenic effects and primobolan for mild anabolic effects - those are two well-tolerated, ‘worth it’ drugs.

With Ovidrel, do you experience the same level of testicular stimulation?

Increased estrogen from TRT causing slight glow and darker skin tone. If you’ve ever taken an AI or DHT derivative, you will see your skin get paler. If you let your estrogen climb, you will see your skin become more supple. There are many estrogen receptors in the dermis...

Daily injections are easy to remember, but they may become tedious over time. I personally inject daily and have successfully for nearly 2 years. Like you, I am very sensitive to medications and am prone to anxiety. A calendar event with notifications should be simple enough for every other...

If you consistently don’t feel good around the Sunday/Monday mark, it would be worth trying and every other day injection frequency. Certain men on TRT feel better with more frequent injections. Don’t get caught up in detailed explanations or overly complex protocol suggestions here. Make a...

Nope. HCG possesses unique effects on the central nervous system (brain) that results in anxiety for some men.

Exogenous testosterone and HCG have both consistently elevated anxiety levels for me. I have not found a sustainable solution to this issue. My comment is merely to help you feel normal in your experience. Experiencing anxiety on TRT is fairy regularly talked about.

Ibutamoren is to HGH what Clomid is to exogenous testosterone…both will raise targeted hormone levels, but the two drugs promoting endogenous production result in a host of side effects that far outweigh their alternatives.

Yep. Ibutamoren is a crap drug. This is what it feels like, coupled with anxiety.

Accept it and bald gracefully. Too many men fight the inevitable, putting their self-esteem into their remaining locks. Get into shape if you are not, and buzz it. Bald gracefully.

Androgens have a direct and strong impact on dopamine, so the likely answer the your questions is yes, titrating up or down, or changing protocols bring about mental changes that are in part attributable to changing levels of dopamine. Wellbutrin has been good. Honeymoon benefits wore off...

This has been my logical assumption and experience. I now take Wellbutrin as of the past 6 months, and I do not experience nearly the side effects while changing protocols compared to before Wellbutrin. Wellbutrin, surprisingly, has seemed to minimize dopamine fluctuations during hormonal...

It’s more likely to be considered observational as opposed to correlational. They observed the described effects without any intervention.

Coupled with the right level of DHT, I would agree.

Nothing specific for fertility. Just HCG.

You can always start lower, get an analysis 3-4 months in, and reassess if you need to increase the dose.

That is a fairly high dose of HCG. Did your doctor mention this study? https://www.healio.com/news/endocrinology/20190323/lowdose-hcg-can-prevent-sterility-in-men-prescribed-testosterone 500 IU of HCG every other day has evidence to be effective for restoring fertility while avoiding...

I was considering and now you’ve made me reconsider. So you’ve met your threshold of helping at least 1 person.

Here is an interesting in vivo study with findings suggesting that lower levels of estrogen in the brain correlate to higher performance in varying forms of memory recall in men. @Cataceous @readalot @Nelson Vergel If a man were to experience brain fog and reduced memory recall while on TRT...

Sure. Change esters quarterly.

When my wife and I conceived last year, I had been on TRT for a decade. Without HCG, I literally had no semen upon orgasm - none. For about 3 years prior to conception, I used very low doses of HCG - 500 IU weekly or less. About 4 months away from conception, I upped my HCG dosage to 500 IU EOD...

As long as the dosage of primo used keeps E2 within range, the effect on lipids should be minimal.

Same boat. It works well for estrogen management - not a silver bullet, but works well.

Yep, and I just rode it out, and those symptoms cleared up.