Search results

Yea based on your analysis it probably was an issue, which is surprising given that 200 mcg is still within the lower end of what is typically dosed. My MC4 receptors must have still been hypersensitive I do need do check what endogenous levels of MIF1 are. I know that when I tested alpha MSH...

I already take ox bile/tudca with meals for fat digestion. It helped increase my cholesterol levels which were low at 100 at one point to like 130. But this compound isn’t a stimulant. MIF-1 is not releasing nor inhibiting reuptake of DA/NE. Actually its not really acting on NE much. Standard...

I just started the thread here about MIF-1 MIF-1 (and other peptides) for Anhedonia/Depression

Thought I would start a discussion about this awesome lesser known peptide, yet one of the peptides with quite a few actual human studies behind it. So I'll start with my experience before getting to the science: I have done a few cycles (they last 5-7 days of 8-10 mg) of it this year and...

Probably better for another thread specifically on MIF-1, I'll make one soon in the Mental Health forum. But I've done multiple cycles of it and each one is kinda different. The 1st one I did back in May I didn't even feel anything until like the 4th day when suddenly while at an outdoor mall I...

I think PT-141 (bremelanotide) is quite dangerous, years back in 2018 it sent me into a severe anhedonia episode at 200 mcg. Had to get ECT. I had symptoms basically resembling that of PSSD/PFS just from using it once. Then I was fine for years until last year, when post covid an alcohol...

Does kisspeptin affect/enhance emotions in any way? More than the T stuff ive been more interested in this. I had found this study about limbic activation from KP https://neuro.psychiatryonline.org/doi/10.1176/appi.neuropsych.20220087

I haven’t found anywhere else myself, its like the only place I know of. Ive been looking for a legit clinic that has it and you see tons with all kinds of other peptides but somehow they don’t have the one peptide with so much actual human studies behind it. I was in a pretty bad place a...

Thanks, its still been a rough ride but I am closer and MIF-1 kinda gave me some hope. Its a gem. I hope one day HRT/peptide clinics look into this. Gut health also seems to be important, on a Rifaximin cycle right now. I feel like ive learned a lot about biohacking and the body in this tho...

I found the peptide MIF-1 really helpful for anhedonia. The effects don’t fully last but it does raise my baseline when cycled (5 days at a time) every few weeks. I remember the first day I took it the entire world was super bright. Felt almost like MDMA-lite. Its too bad many peptide places...

Just to add, theres some debate nowadays whether MAO-B metabolizes dopamine at all. The wiki article on MAO-B mentions this and references this study Redefining differential roles of MAO-A in dopamine degradation and MAO-B in tonic GABA synthesis MAO-B inhibition does increase DA indirectly...

Direct Allopreg 3 mg was one of the few things that was massively helpful for my anhedonia problems I am going through, but only the very first time. Since then it doesn't really work or only mildly helps. However its one of the things I've taken with basically 0 side effects. SSRIs are bad...

Accutane, Ashwagandha, Spiro etc are all super risky whether on TRT or not, since they all have reports of anhedonia

That is really interesting. I wonder what mechanism leads to that. I always had a feeling keeping things too stable isn't great. I see that low dose Selegiline an MAOI is also mentioned in that thread which is something I was considering to get me out of this episode as well. But right now 30...

That's the first I've heard of T making it worse. I myself never experienced anything like this with T. Do you mean to say TRT caused flatness directly, or that some other stuff created flatness and more T made it worse? I have already been on TRT for years before I ever got this from the...

I don't see how this is a "drug-problem". I don't abuse anything. This happened after a 1 time use of alcohol a month or so post-covid. In the beginning first month I didn't take anything but I wasn't getting better. I'm taking stuff therapeutically like LDN and MB. And a course of the peptide...

No major vacation recently, although I've gone on like 1 road trip. I can't really feel the excitement so I don't think I would enjoy a vacation. Don't have a relationship and I don't think I can even pursue one like this as my social skills as well as sexual function are affected. The emotional...

I did not know that about MegaSporeBiotic. Haven't noticed anything negative myself though. It was just recommended by my functional doc. Akkermansia I was somewhat low in on my microbiome test which is why I take it, and L.Reuteri is supposed to increase oxytocin which is involved in emotion...

Just a lactulose breath test from Genova. I had hydrogen levels off the chart at like 130+ initially. Now they are like around 65. I don't eat yogurt but I take the probiotics MegaSporeBiotic, Akkermansia, and L reuteri from biogaia.

MZ biolabs in Arizona also does testing

I don't take allopregnanolone anymore, only used a few times many months ago. Had genital numbness before I ever took pregabalin. LDN is one of the things that helps me a little and actually reduces gut inflammation + increases motility which is supposed to help SIBO actually. Its not a...

What treatments are good for anhedonia and blunting? I've been on TRT for many years, since around 2016-2017 to now. I got on it for anxiety and low mood issues and it did eventually help and I completely recovered. I did not have anhedonia then. I also take HCG and Preg occasionally. And my...

Yea and watch people get gaslighted by doctors as usual saying "the medication didn't cause it! The studies don't support this!" just as with PSSD, PFS, etc. I don't understand how they couldn't forsee this with a drug that affects reward pathways in order to reduce cravings. Anhedonia is...

I am trying it recently for anhedonia issues that began in September after a hangover that was a month after covid and it is helpful but not enough.

I think there are some risks with Ozempic too regarding Anhedonia. It is affecting the reward system: https://www.webmd.com/obesity/news/20230612/popular-weight-loss-drugs-can-carry-some-gnarly-side-effects Anecdotes too: Given how debilitating a condition like anhedonia can be, its far...

I'm not for SSRI ADs, but in general, lets say you feel depression symptoms out of nowhere. Even things like Long COVID have caused people to get anhedonia. What are you even supposed to do to solve it? Its really hard for psychological interventions to solve a biological dysfunction so one has...

Finasteride doesn't just affect DHT in the blood. It messes with allopregnanolone which is critical. And lowering allopregnanolone can lead to all sorts of other stuff like gut inflammation issues: Gut Inflammation Induced by Finasteride Withdrawal: Therapeutic Effect of Allopregnanolone in...

I started at 21 while in college having low motivation/mood/anxiety issues from HPA dysregulation and I am 29 now. My T levels were not that low at around 400-450 although my E2 was around 15-20 so low ish. It helped quite a bit, not a full cure and I still had mood swings but over time things...

It can be an extremely dangerous dangerous peptide IMO, melanocortins are involved in anhedonia: Why the thrill is gone: Scientists identify potential target for treating major symptom of depression. I actually had a very bad case of induced persistent anhedonia years ago from using this...

So an update. Turns out I have a very bad case of SIBO (small intestine bacterial overgrowth) with breath test levels of like 130+ in H2, and some slight elevation in methane as well. Basically the theory is that extreme SIBO can create a stress on the body and then lead to inability to handle...

Finasteride issues aren't easily identifiable on lab tests to begin with, as the issue is one of androgen receptors or allopregnanolone (the body's natural benzo) in the brain. AlloP is a very important neurosteroid for mental health.