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Where did you see that? And are you sure its not the other MIF aka Macrophage Inhibitory Factor? Key role of MIF-related neuroinflammation in neurodegeneration and cognitive impairment in Alzheimer's disease - PubMed This is about a different MIF. Not MSH inhibiting factor

Been a while since I updated here. Its been very up and down for me in general. Windows and crashes from various things. Helpful still are GABAergics. I am on Gabapentin 600 mg which helps my anhedonia, and Armodafinil 75 mg. These are just bandaids. Same with cycling MIF-1 monthly. Ipamorelin...

So I started this like 3 days ago, at 50-100-167 mcg. Will stay at 167 mcg for now 5 days on and 2 days off. I take it an hour or so before bedtime And this thing definitely has some mental effects, but they are subtle. Feels GABAergic actually which my body seems to love, helps sleep. It is...

Probably nonsense, but I've seen some rare horror stories and broscience about this in regards to Cerebrolysin which might be the one you are thinking of. I haven't heard about this with others.

Do you also have SIBO and dysbiosis? The hunger feeling this peptide can give is interesting to me as for me hunger has correlated with better hedonic tone. And I know I have heard of Ozempic/Semaglutide causing anhedonia/blunting and it actually blunts cravings/hunger. And it seems like in...

I was recommended Ipamorelin by a functional doc for improving motility/gastric emptying for SIBO. Note I already take Motility Activator (which has ginger+artichoke extracts), drink chamomile tea, but its not enough. I also noticed that when I feel hungry I feel better mentally-more hedonic...

I just found this today, thought I would share it https://www.adxs.org/en/page/104/neurological-aspects Gets quite deep into the weeds but its very cool. It mentions ADHD but the material also talks about stress/depression/anxiety as well. Has a section for every commonly known NT and...

Damn, yea oral is one of the worst ROAs for this I heard. Not many anecdotes for IN, but subQ seems to do it less although it still can. Back when I took it years ago I had done subQ.

I've always suspected neurosteroids were involved along with the gut. This paper is really good. It seems like perhaps Zuranolone may be a potential treatment according to this theory?

Yikes, it's so strange because it seems like it can both help or hurt dopamine badly. How much did you take, what ROA (oral vs subQ vs IN), and how long did it last? Years ago in 2017 a cycle of BPC-157 actually seemed to help my HPA axis low mood issues and helped get out of mild benzo...

Searching around, there seem to be a quite a few anhedonia reports from BPC-157. Any ideas why this happens? It also seems to be more from the oral form than the subQ form. I remember years ago I took it and I was fine, it actually helped my mood (didn't have anhedonia issues back then)...

Selegiline which is an MAOB inhibitor at low doses actually mostly increases trace amines like PEA, not dopamine. Although PEA indirectly is a releaser of DA and NE as its basically endogenous amphetamine. https://www.nature.com/articles/s12276-021-00646-3

Every time I do a cycle it seems to be different. Sometimes it can be subtle and other times 'woah'. In this cycle it was subtle but noticeable in that I noticed increased optimism, peace, and more anticipatory positive thoughts looking forward to stuff, so decreased anticipatory anhedonia.

Theres only 1 source really I know of right now Limitless Life Nootropics. Couldn't find anything else. I did another cycle just over a week ago and it helped raise my baseline again. This time it was more subtle and only a slight boost but well I'll take it. It did make armodafinil seem to...

I don't trust these typical FDA RCTs for depression anymore. It could be that Zuranolone is good for certain subtypes of depressions. The problem is MDD as a diagnosis is too heterogenous. What would be nice is if we start having proper stratified trials and then see. May be that people who...

Over time on TRT which I began around 2016 in my experience pregnenolone did come back up. In the beginning I did notice a drop way back but somehow it just normalized. I did use HCG+Preg but later even without those it stayed up. At least until my current issues last year triggered by the...

Oh damn, have you had anhedonia your whole life basically? I can understand being wary of ECT, especially the risks of memory loss are higher with age. I was 24 when I had it.

No thankfully I didn't. I also took Galantamine though 4 mg bid since a few days before and during the treatments. Some studies said it prevented memory loss, and I can't be sure it was that but yea. I did feel kinda foggy for a few weeks but that subsided in a month. I was back to school for...

Yea it did, back in Feb/Mar 2018. I dont recall exactly but it was like 12 or so sessions. I remember with unilateral was first 6 and that mainly helped anxiety a lot but I needed bilateral and after the 2nd bilateral coming home sleeping and waking up like a switching was flipped. Then I needed...

Yea, I went to him after a severe reaction to PT-141 a melanocortin peptide years ago which gave me severe anhedonia. He pretty much did not know what was going on. It did not fit into his HPA axis theories at all, bloodwork looked fine. He just told me it was psychosomatic eventually. Useless...

Its only in recent years I learned there is a Post Aromatase Inhibitor Syndrome like PSSD/PFS. Rare but I did use arimidex occasionally way back in 2015 at like 0.1 mg but thank god I never got that. Only a handful of times used it. I think it must be to do with neurosteroid estradiol rather...

I've wondered if the initial drop in T triggers anxiety/OCD neural pathways in people that take time to resolve even beyond the TRT. I remember at the beginning of my issues I used to think high E2 was creating symptoms but over time and one day when I got better it literally did not affect me...

Arimidex is powerful stuff and E2 is needed for the brain. People have messed themselves up with AIs. Unlikely that high E2 is even the issue.

Its much more than sexual dysfunction also, often includes anhedonia/emotional blunting and other cognitive symptoms that are debilitating

Seems like low pregnenolone may have been the issue. There were some theories in the past about TRT without HCG/Preg over time lowering Preg levels.

How bad is your anhedonia typically? I wonder if one reason I respond to MIF1 strongly is because years ago I had a severe PT141-induced anhedonia episode that I needed ECT for. Shit was a nightmare and basically I had the severity of severe PFS/PSSD cases (blank mind, anhedonia,blunting...

Do you also have anhedonia/blunting as part of PSSD? Or just sexual symptoms

Yea there can definitely be a delayed effect. For me I noticed with doing more cycles though the effect came earlier on. Its weird. But even Ketamine (which im trying now) seems to have a delayed subtle effect for me. Im planning on doing maybe 4 infusions (done 2 now) and then I will have...

It consistently shows up in my usual bloodwork I get while on TRT and nothing has been done I also wonder if whatever potential infection is behind my low cholesterol too, and also causing my SIBO stuff

Does TA1 help with potential chronic infection? Ive had high eosinophils (0.7 on a range of 0-0.4) for like over a year now. And also earlier this year had low CD57 NK cells. And I wonder if chronic infection is behind some of my mental issues and sensitivities to things like caffeine which...

The concern is that RC/nootropic peptide sites are next. I fear this is just the beginning…