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AI has some ideas as to why scrotal application may create more E2 than some other sites: Aromatase enzyme levels are indeed present in scrotal skin, as well as in other areas of the body. However, specific research comparing the levels of aromatase in scrotal skin to other body regions is...

This is the nugget of truth from the video. Different sites may differ in at least three important ways that will influence outcomes: 1) Absorption of testosterone 2) Amount of 5-alpha reductase enzyme 3) Amount of aromatase enzyme So for the same amount of testosterone cream applied to any...

This is not caused by androgen receptor density. Androgen receptors do not participate in the metabolism of testosterone into DHT or estradiol. This is a fundamental misunderstanding of biology that I've heard Cortex express in his videos. Here is what causes increased DHT levels with scrotal...

Please explain to me how the androgen receptor density of the application site affects systemic absorption, or metabolism of testosterone to DHT and estradiol, or anything else besides local growth of tissue at the site.

My reactions to this video: Why is he always talking about the androgen receptor content of application sites? What does that matter? Why does he think that is relevant to absorption or metabolism? This is one of those moments where I feel like he reveals himself as being less than an...

Do you have some regular blood test results for the sex hormones? I wouldn't put much stock in saliva testing.

t-max 2 hours, half-life 16 hours (this info from the scrotal pharmacokinetics study with some minor extrapolation to determine half-life). This means 18 hours after application you should have half the serum testosterone levels that you had at the 2 hour peak. Serum DHT and E2 behave...

You changed two things at the same time, which you never want to do. In some men, subq injections produce lower testosterone levels and higher E2 than the same dose IM. And then besides the numbers, some men just don't feel as well with them. If I were you, I would immediately reverse at least...

Cataceous is the undisputed king of creative analogies to explain how SHBG affects hormone levels.

I actually had the same experience which was very counterintuitive. The same alphagels formula that burns the crap out of my delts and abdomen doesn't bother the thinner, more fragile genital skin. Go figure.

This is not why it takes weeks. Your levels after just a couple injections of a long ester are already 60-80% of your final max serum levels. If it were levels alone that determined the effects, you would have 60-80% of the max benefits at that moment. Why don't you? Sure, there are some...

I experienced close-to-immediate improvement of erectile function. On the other hand, if the libido effects of TRT typically take at least a few weeks to kick in, I don't see why the timeline with pure DHT would be any different. If something positive happens immediately, that's great, but I...

I think what you are saying here is that beyond the reduction of total E2 that will be caused by SHBG reduction, there will be a further reduction of total E2 because of the SHBG that remains, less E2 will be bound to it due to displacement by proviron. This latter effect then could produce a...

I think constant high levels of the sex hormones can feel SSRI-like, where your mood is kept very even, you are insulated from events affecting you, and emotions are constrained. I think this can happen even when E2 is high, provided it is kept persistently and stably high over a long period...

Maybe? I don't know. Not that I can find. If we put the anecdotes aside, we're left with very little in terms of useful information. The few studies that exist on the topic may be misleading or irrelevant - for example: FSH-induced aromatase activity in porcine granulosa cells...

https://anatomypubs.onlinelibrary.wiley.com/doi/10.1002/ar.22439#bib8 "In addition, mesterolone has a high binding affinity for the enzyme aromatase that converts other steroids into estrogen (Brueggemeier,1994), even though it does not undergo ring aromatization to estrogen (El-Sadr et...

Cortex was saying recently that he sees minoxidil causing PFS-like issues.

12.5 mg twice daily.

Anti-estrogenic. Unlike DHT, proviron binds to the aromatase enzyme and actually lowers serum E2. Neither DHT nor masteron do the same. DHT can interfere with E2's activation of gene transcription and has an anti-estrogenic effect that way, but Proviron inhibiting aromatase takes the anti-E...

Haven't taken it long term - I basically used it just long enough to get some labs and make sure it was legit. I'm experimenting with something else currently.

It's not that bad after you get used to it. Yes, it makes the area red shortly after application and feels a little "burny", but it doesn't stay like that for very long. I don't know if you've ever taken high dose niacin and experienced a niacin flush, but it looks and feels similar to that.

Ran DHT again, same doses of Alphagels 20% DHT and similar timing, this time with scrotal application: 408 ng/dL

Proviron is too strongly anti-estrogenic for me and makes me feel like crap. Better results with actual DHT in my case or even masteron.

Very likely he's taking a 5-ar inhibitor to keep his hair.

No, however, I drove a Miata with the top down and no sunscreen for about five years from age 33-38, which drastically accelerated my skin aging. My wife warned me that would happen and urged me to wear sun block. I ignored her and here we are, with deep forehead lines and etc.

I think an important difference there is that the 20-30 pg/ml range was found to be optimal in natural men, while the higher E2 levels were associated with better libido in men on TRT. A natural with E2 over 40 PG/ml would have a very low testosterone level and very low T/E2 ratio due to...

Yep, that will do it. Welcome to the club!

"We feel this is a notable improvement over our previous carrier of motor oil and and hydrochloric acid"

Injectable testosterone does not produce DHT numbers that high, regardless of your dosage, and regardless of the timing of measurement.

65 ng/dL when I was on 140 mg test enanthate weekly. Have not tested recently on 175 mg test prop weekly. I would guess something like 80-100 ng/dL.

I tested 317 ng/dL DHT after a couple applications of 1 ml on shoulders, the night and morning before test. Tested 5 hours after morning application.