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My 4-month trial of Metformin (1.5g) proved me right: For all the wonderful health and ligevity-enhancing benefits, I' experienced a 36% drop in total testosterone since starting which I knew about and several studies have shown. I was already low normal (high 400s) which was not optimal, now am...

I am 99% certain my high normal (for my age of 62) of 258 is from eating a diet in which my protein is mostly all from non-plant sources (cultured dairy, eggs, lean meats, fish, poultry, whey) + supplements like DHEA + training. I prefer this type of protein over anything plant-based. This...

Anyone have data showing that if one's natural IGF-1 level is high normal for one's age as in my case (see below), would GHRH/GHRP peptides be contraindicated since they raise IGF-1 over time? The concern is not as bad as with straight GH, but is still an issue for long-term (cancer, CV disease...

How is it possible that I can take a higher dose of NDT and do my labs at the same time as prior and come out with lower TSH and T3? Prior labs (NDT dose @ 2.00 grains - 130mg): TSH: 2.03 FT3: 3.70 FT4:1.40 Current labs: (NDT dose @ 2.25 grains - 146.25mg): TSH: 3.29 FT3: 3.5 FT4: 1.5 No...

Has anyone seen better glucose results with immediate release v extended release? I also wonder if my 1.5g ER-niacin could be suppressing the effects of metformin. Metformin and Niacin SR Interactions - Drugs.com

Even more effective than Semaglutide, a GIP/GLP-1 combo, the latest! How were you able to get a scrip? How long on it? Besides you "feeling" less glucose, has it actually reduced fasting glucose levels? Weight/fat loss? How's the nausea? Constipation from delayed emptying?

I'm in the same boat always having had high FBG. Even if I eat a protein snack at night, it just raises my glucose levels the next morning. It just hangs. Was hoping Met would suppress that. Only thing that suppresses it is moderate exercise like taking a walk or fasting for 15+ hours and...

I assume you're non-diabetic? How long have you been on it? Strange our glucose readings don't change. I still don't understand exactly the mechanism but I think it has something to do with glucose homeostasis in that diabetics have impaired beta cell function whereas non-diabetics do not -...

I've been on Metformin for a month now. I am not diabetic and am taking it for the anti-aging and cardiovascular benefits, etc. I eat the same diet (low carb). I have not seen any difference in my fasting or postprandial readings. Same issue with taking berberine (which I still take with...

The new GLP-1 + GIP all-in-one, Mounjaro. More here.

Interesting mechanism. In my case, despite my low carb diet (<100g), I think my insulin sensitivity has gradually degraded with age as is normal. I take glucose disposal agents like cinammon, banaba leaf, berberine, etc. but have not noticed much difference. I'm looking into metformin and...

That seems to be a paradoxical to what one would think: that fasting would keep the fasting glucose levels lower and a bedtime snack would make them higher. Can't figure that one out. I am just the opposite. If I snack, my readings will always be higher, especially with any form of carbs or even...

Down 12 lbs now. Starting to see the bicep vein gives me hope that fat loss is possible. I still credit this with the slight increase in my desiccated thyroid dose (I believe I was under-dosed). May need to bump the dose a little more so TSH is @ <2.00 (it's around 2.5 now). That and more days...

Update: I have lost approximately 10 pounds since starting this thread. Some of that of course has been fat as well. Strength has gone down maybe a tiny bit. Calorie restriction is difficult but a necessity at this point. The only other thing that I still need to work on is hormone optimization...