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I used Tirosint before the price went through the roof. It used to cost the same as Synthroid now it is 10x the price. Overall I liked it. Would still be on it if it wasn't for the price.

Yes, I've tried it, and like with all other protocol changes for me it produced a libido boost for a short while (a few days) and then I went back to baseline. I've also been on cream only, no injections, and that didn't help either when on a stable protocol.

The only people I've found who do well on generic T4 are people who I've met IRL. They feel great and have never spent a minute of time on internet health forums. When I talk about all the trouble I've had trying to get my thyroid treatment dialed in they look at me like I'm nuts.

There are studies that show that Synthroid and the generics are not always equivalent. They are summarized in this article: Synthroid vs Levothyroxine: Should you Switch Thyroid Medications?

Always about 27 to 30.

I also only get a boost in libido when making protocol changes, or even more when I take a break for a few weeks from TRT. I also agree that for many there is no such thing as a sweet spot, I certainly haven't been able to find one in more than 7 years trying.

You might want to spend some time reading www.tiredthyroid.com, or buy her book. Here is one of her entries on rT3: Do thyroid receptors really get blocked and take 12 weeks to clear? Is T4 really the problem?

High Reverse T3 (rT3) Can be a Sign of Too Much T3

It will bind to thyroxine-binding globulin just like endogenous T3, so it should raise both total and free.

I was taking 65mg of Westhroid. I was getting hyper symptoms so I wasn't going to go higher. Messed around with lower dosages for a while then just went back to T4 only. My last labs on 50mcg of Unithroid were TSH=1.47 (0.5-5.8), freeT4=1.15 (.75-1.64) and freeT3=2.66 (2.0-4.9). As a result of...

It's not clear from your post why you are taking thyroid other than you don't like your labs. What symptoms are you trying to address by taking thyroid meds? Your labs on NDT are very similar to what mine looked like on NDT. I found that I don't have a problem converting T4 to T3 as needed and...

Nelson posted this a while back: Water Retention Caused by Testosterone May Have Nothing to Do with Estradiol

The authors are from McGill and funding was, in part, from the Canadian Institutes of Health Research

Well for some reason I'm somewhat immune to the effects of some anesthesia agents. I don't know what they used when I had my biopsy done but it was one of the most excruciatingly painful experiences of my life. Like someone piercing your anus with a red hot poker 21 times. I almost passed out...

It depends on how the manufacturer calibrated the scale on the syringe. I order for the volume to be accurate for small volumes the scale would need to be non-linear. In other words you need to draw the plunger back further for the first .05mL than for the last, but the scale doesn't reflect...

So are you supposed to take into account the volume of the plunger with these low dead space syringes? The 0.05mL in your photo includes the volume of the fat part of the plunger, so in fact the amount of test. cyp. is a lot less than 0.05mL. It seems that that plunger messes up the volume you...

I found that it seems to depend on how well the pharmacy did at getting air bubbles out, how well it was mixed, and also the cream base that was used. I received one topi-click where it seemed that the cream was almost foamy, I'd turn 2 clicks and it would take about 10 minutes for all of the...

I read it wasn't much better than placebo: Bait and Switch: the Great Ketamine "Breakthrough" | RxISK

Your Genetic CAG Repeat Number Determines How Well You Will Respond to Testosterone I had looked into getting genetic testing for this a couple of years ago and the only lab I could find to do it was in Europe and even if I could get a sample to them it cost something like $1500

There certainly are those for whom TRT has solved their mental health issues, PeakT always said that TRT cured his lifelong depression. But clearly there are those of us who get little to no benefit and maybe even do a little worse in some respects on TRT. I do think that is it primarily driven...

95-100% chance that in 6 months he'll tell you what you really need are anti-depressants. But more seriously, you should aks him how many patients he has on TRT and what his criteria would be in 6 months to put you back on if no underlying cause is found.

Meh, nothing really new there, plus the Amy Cuddy research has been thoroughly discredited.

While that may be true in general I'm 57 and have never found a protocol that got me anywhere near "dialed in" in 8 years of trying, but I've never tried T-propionate and after the recent thread on the subject I'm going to give that a shot.

I'm in MA and, unless this is something new, I haven't had any trouble ordering up to a 6 month supply from an out of state compounding pharmacy.

Are you sure the guys saying they feel worse on more frequent injections aren't also switching from IM to subQ?

Okay, I see your point, but considering that those videos only get around 1k views it doesn't seem that many guys will find out about it and even fewer will try it. So only a fad among a very small group of guys.

I wouldn't call it a new fad, I saw a doctor 8 years ago who prescribed this and he had already been doing it for many years, said he learned it from Dr Shippen I believe.

I thought Dr. Shippen retired last year?

The same could be said of TRT. Look at all the T mills and clinics making money off of it, not to mention how expensive Androgel and other big pharma T preparations are. Yes there are lots of reasons to avoid psych meds, and lots of reasons to try TRT instead, but cost and isn't really one of...

I just spent 10 minutes looking at GoodRx.com and all the SSRI's I found over there are $3-$10/month. So they do end up being typically cheaper than TRT, which is an added incentive for Doctors to prescribe.

If you have no apnea it is doubtful that a CPAP machine will improve your oxygenation. Sounds more like you would need to use supplemental oxygen at night. There are also a lot of other reasons why you could be waking up in the middle of the night. Such as too high or too low cortisol. But if...